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Biomedical subjects

W Adam

Publications and source records attributed to W Adam.

204 records · Page 12Linked to original sources
PubMedDate not supplied

[Therapeutic results with tamoxifen in oligospermia. II. Hormonal analysis and semen parameters].

During a five months lasting treatment with tamoxifen (2 X 10 resp. 2 X 20 mg daily) a significant increase of testosterone, LH, FSH, estradiol, free testosterone and SHBG was found. The prolactin levels diminished. In semen analysis the values of pH and fructose decreased within the normal range. The sperm density increased significantly, but we could not ascertain whether a dosage of 2 X 20 mg/die will provide better therapeutic results. Furthermore the hormonal and seminal investigations described in this paper did not allow to predict those patients who would be good responders on tamoxifen therapy. Tamoxifen seems to be effective in normo-, but also in hypo- and hypergonadotropic patients.

Estradiol↗
PubMedDate not supplied

[Stiff-tail or midpiece syndrome].

A rare spermatological malformation was seen in a 40 year old Turkish man with unexplained infertility since 17 years. Most of the spermatozoa were completely stiff, some of them developed a decreased motility confined only to the end of the flagellum. Electron microscopy studies revealed strongly elongated and partly disorganized mitochondrial sheaths; cytoplasma droplets were found frequently.

Acrosome↗
PubMedDate not supplied

[Tamoxifen treatment of oligospermia. Mechanism of action and metabolism].

210 males with idiopathic oligozoospermia or oligo-astheno-teratozoospermia were treated with tamoxifen (2 X 10 resp. 2 X 20 mg daily) over a period of five months. Investigations which were performed concomitantly revealed no significant changes in body weight, blood pressure, blood sedimentation rate, red and white blood count including the number of thrombocytes. In the multi-analysis of serum we found significant differences within the normal range concerning the following parameters: creatinine, albumin, cholesterol, phosphorus, sodium, calcium, alkaline phosphatase, LAP and gamma-GT. Most of those changes in serum values could be explained by an anabolic metabolism due to an increased testosterone level and by additional stress of the liver function. On 41 of those patients an ultrasonography of the testes was performed; in more than 50% the testicular volume increased during therapy with tamoxifen.

Adult↗