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Biomedical subjects

W A Thomas

Publications and source records attributed to W A Thomas.

At least 91 records · Page 5Linked to original sources

Distribution of intimal smooth muscle cell masses and their relationship to early atherosclerosis in the abdominal aortas of young swine.

In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent in the ventral quandrant than in the dorsal or either lateral quadrant. In the proximal half, intimal cell masses are more frequent in the dorsal quadrant. When experimental atherosclerosis is induced in the abdominal aortas of young swine by either a hypercholesterolemic diet or by aortic ballooning followed by a hypercholesterolemic diet, the distribution of early lesions is similar. The lesions are found predominantly in quadrants where intimal cell masses were found to be most frequent in the control group of swine. The results suggest that most of the lesions, though not necessarily all, arose from pre-existing intimal cell masses beneath the aortic surface.

Animals↗

Equitable considerations in balancing the energy equation.

Decisions concerning how we balance energy supply and demand should not be made by quantitative cost-benefit analyses alone. The distributions of costs and benefits among individuals, groups of individuals, nations, and generations raise questions of equity that need to be addressed forthrightly. Doing so can help rather than impede the decision-making process.

Cost-Benefit Analysis↗

Peptido-aminobenzophenones--novel latentiated benzo-1,4-diazepines.

It has been shown that cleavage of the N-terminal L-amino acids of a novel series of dipeptide derivatives of 2-aminobenzophenones occurs readily in vivo to give benzo-1,4-diazepines. Such compounds may serve as useful pro-drug forms of minor tranquilizers such as Valium.

Animals↗