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Biomedical subjects

W A Rolston

Publications and source records attributed to W A Rolston.

5 recordsLinked to original sources
PubMed1993

Adjunctive therapy in thrombolysis for acute myocardial infarction.

The value of prompt coronary reperfusion utilizing thrombolytic therapy during acute myocardial infarction has been well established. However, new data indicates that although rapid reperfusion is imperative, this positive effect may, in fact, be partially or totally negated if patency is not sustained and complete. The following manuscript discusses the role of adjunctive agents in thrombolysis that are essential in preventing coronary reocclusion. It is this important function that serves to prevent recurrent ischemia and reinfarction, thereby improving resultant left ventricular function. This, in turn, should have a positive effect on post-thrombolytic mortality. The data presented in this paper supports high dose, titrated intravenous heparin and aspirin as required adjunctive therapy to thrombolytic treatment in the setting of acute myocardial infarction.

Aspirin↗
PubMed1977

Echocardiographic appearance of ruptured aortic cusp.

Serial echocardiograms of a patient with enterococcal endocarditis and aortic insufficiency suggested the presence of vegetations on the aortic valve with progression of the lesion to frank prolapse of an aortic valve cusp. At surgery, the patient was found to have a flail noncoronary cusp to which an 8 mm vegetation was adherent. Anatomic correlations are presented, and a possible mechanism for the unusual echographic findings is discussed.

Adult↗
PubMed1977

The role of adrenergic receptor blockade in serotonin-induced changes in the pulmonary circulation.

1. In dogs i.v. injection of serotonin caused a rise in pulmonary artery pressure and pulmonary arteriocapillary resistance that persisted even after alpha- and beta-adrenergic receptor blockade; pulmonary venous resistance also increased, but this was abolished by pretreatment with either propranolol or phenoxybenzamine. 2. The injection of serotonin into the ascending aorta produced an immediate rise in systemic, pulmonary arterial and pulmonary venous pressures and pulmonary venous resistance. After phenoxybenzmine, the rise in systemic and pulmonary arterial pressures remained unchanged, but previously observed increases in pulmonary venous pressure and resistance were blocked. In contrast, propranolol failed to abolish the rise in pulmonary venous resistance after serotonin injection into the ascending aorta. 3. These results confirm the observation that the vasoconstrictor effect attributed to intravenously injected serotonin on the arterial side of the pulmonary circulation is independent of the known sympathetic pathways. The data suggest that the pulmonary venoconstriction induced by intravenous serotonin is of reflex origin, abolished by alpha and beta receptor blockade, whereas the efferent arm of the reflex pulmonary venoconstriction following injection of serotonin into the ascending aorta is mediated via alpha-adrenergic receptors.

Animals↗