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Biomedical subjects

W A Morningstar

Publications and source records attributed to W A Morningstar.

8 recordsLinked to original sources
PubMed1981

The ocular pigmentary disturbance of human Chédiak-Higashi syndrome. A comparative light- and electron-microscopic study and review of the literature.

The ultrastructure of the ocular pigment abnormality of human Chédiak-Higashi syndrome is described. The presence of giant abnormal melanosomes, probably the end result of the fusion of smaller abnormal organelles, was the most striking pathologic finding. This defect involved both optic cup and neural crest-derived melanocytes; the former were affected more severely. Giant lysosome-like organelles were also observed.

Chediak-Higashi Syndrome↗
PubMed1979

Bronchiolo-alveolar carcinoma with nodal metastases. An ultrastructural study.

A case of bronchiolo-alveolar carcinoma of the lung was studied by light and electron microscopy. Type II granular pneumocytes were seen in the lymph node metastases of the tumor, a finding not reported previously. We feel that the presence of these cells in metastatic foci indicates their neoplastic nature, and provides evidence that bronchiolo-alveolar carcinoma arises from type II cells.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1977

The renal pathology of Chediak-Higashi disease: usefulness of the urinary sediment as a confirmatory diagnostic test.

The presence of large cytoplasmic inclusions, thought to be abnormal lysosomes, seems to be the cytological hallmark of Chediak-Higashi disease in both humans and animals. This cell anomaly, originally reported in the leukocytes, is also present in various tissue cells, including kidneys. In the patient described, the abnormal inclusions were identified in renal cells of the urinary sediment. Thus, urine could provide a convenient source of diagnostic material in patients with Chediak-Higashi disease. In addition, the ultrastructure of these inclusions is described for the first time in human renal tissue.

Chediak-Higashi Syndrome↗
PubMed1975

Whipple's disease. An example of the value of the electron microscope in diagnosis, follow-up, and correlation of a pathologic process.

Two cases of Whipple's disease were followed by electron microscopic study of periodic peroral suction biopsy specimens of small intestine to show the presence and disappearance of the interstitial lamina proprial organisms, the sequential changes of the macrophages, and the return to normal leukocytic population of the lamina propria following prolonged treatment with tetracycline. The value of electron microscopy in the detection of small numbers of micro-organisms is demonstrated. Ultrastructural study is the most efficient method of demonstrating the presence of diagnostic micro-organisms, measuring the adequacy of treatment, and identifying possible early reactivation of infection.

Adult↗
PubMed1975

Problems in the development of a clinically oriented program in electron microscopy.

The educational, organizational, and fiscal aspects of electron microscopy are discussed.. with emphais on the desirability of making electron microscopy an integral part of the formal training of residents in pathology and of the overall educational program of the medical staff. The rapidity of feedback of information from the pathologist to the clinician is stressed. The number of specimens processed and the variety of tissues submitted for electron microscopy can be regulated by the pathologist but should reflect the particular strength of the hospital or its department of pathology. The organization of the electron microscopy facility, its funding, and sharing of the electron microscopy program in the local community of clinical scientists are discussed

Biopsy↗