Comparison of the oxime and the hydroxylamine derivatives of 4-chloroamphetamine as depletors of brain 5-hydroxyindoles.
Explore the source record for details and available documents.
Amphetamine↗
Biomedical subjects
W A Day
Publications and source records attributed to W A Day.
A new method for making phospholipid vesicles and the partial reconstitution of the (Na+, K+)-activated ATPase.
Explore the source record for details and available documents.
Adenosine Triphosphatases↗
Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 1. Structure-activity relationships.
Explore the source record for details and available documents.
Adrenal Glands↗
X-ray diffraction pattern of axoplasm.
Explore the source record for details and available documents.
Animals↗
Biosynthesis of dithiadiketopiperazine antibiotics: comparison of possible aromatic amino acid precusors.
Explore the source record for details and available documents.
Alkaloids↗
A radioimmunoassay specific for [Gln8]LH-RH: application in the confirmation of the structure of chicken hypothalamic luteinizing hormone-releasing hormone.
In the first report on the chemical structure of a nonmammalian LH-RH, chicken hypothalamic LH-RH was demonstrated to be [Gln8]LH-RH [2-4]. However, these studies and subsequent reports [7,8] did not totally exclude the possibility of a reverse sequence of the two amino acids Leu-Gln. In view of the recently described structure of salmon brain LH-RH as [Trp7,Leu8]LH-RH [9], we undertook to confirm our earlier conclusion that chicken LH-RH is [Gln8]LH-RH and not [Gln7, Leu8]LH-RH. The immunologic, chromatographic and biological properties of natural chicken hypothalamic LH-RH were compared with those of the two synthetic peptides, [Gln8]LH-RH and [Gln7,Leu8]LH-RH. A radioimmunoassay highly specific for [Gln8]LH-RH was developed. Natural chicken LH-RH cross-reacted fully with the antiserum which requires the COOH-terminal Gln8 to Gly10-NH2 for binding, while [Gln7,Leu8]LH-RH showed less than 0.1% cross-reaction. On a high resolution reverse phase high performance liquid chromatography system, natural chicken LH-RH co-eluted with [Gln8]LH-RH and was well separated from [Gln7,Leu8]LH-RH. In a chicken anterior pituitary cell bioassay, natural chicken LH-RH and [Gln8]LH-RH were equipotent in stimulating luteinizing hormone release, while the relative potency of [Gln7,Leu8]LH-RH was 4.4%. These data, in particular the use of a specific [Gln8]LH-RH antiserum, provide conclusive evidence that chicken LH-RH is [Gln8]LH-RH.
Animals↗
Small liver fenestrae may explain the susceptibility of rabbits to atherosclerosis.
Rabbits fed cholesterol rapidly develop high serum cholesterol levels which lead to the development of atherosclerosis. This is related to the retention of cholesterol-rich chylomicron remnants in the circulation. In most animals, such as rats, chylomicron remnants are rapidly removed from the circulation by the liver. The first barrier to this removal is the fenestrated endothelium of liver sinusoids. Measurements made of a large number of sinusoidal fenestrae by scanning electron microscopy have shown the average diameters to be 89 nm in rats and 49 nm in rabbits. We postulate that the small size of endothelial fenestrae in the liver sinusoids of rabbits hinders the egress of chylomicron remnants from the sinusoidal blood, explaining the subsequent development of hypercholesterolemia and atherosclerosis.
Animals↗