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Biomedical subjects

W A Cole

Publications and source records attributed to W A Cole.

8 recordsLinked to original sources
PubMed1992

Abduction during custody and access disputes.

In recent years abductions during divorce custody and access disputes have received greater attention from both the lay and medical press. However, little has been written on the psychopathology of the abductors or the impact on children of being kidnapped by a parent. In this study 20 cases of abduction, involving 20 parents and 37 children, were examined after the children had been located and returned to the custodial parent. Characteristics of the abduction and psychopathology seen in the children are compared to those of a control population. The outcome of assessments conducted by the family court clinic after the abductions are profiled.

Adult↗
PubMed1980

Gene-teratogen interaction in insulin-induced mouse exencephaly.

Heterozygotes for the mutant genes crooked (Cd) or rib fusion (Rf), crossed to either strain A/J or SWV produce mutant F1 offspring with minor skeletal defects. If the mothers are also treated with teratogenic doses of insulin, the mutant F1 heterozygotes develop exencephaly significantly more often than nonmutants. That the heterozygous mutant gene increased the embryo's sensitivity to insulin-induced exencephaly was also demonstrated by dose-response curves. For A/J and SWV crosses, probit regression lines for the mutant crosses were fitted to common slopes that were significantly different from those of probit regression lines for the nonmutant crosses. The nonparallelism of the mutant versus the nonmutant groups of lines indicated the presence of a gene-teratogen interaction. Early exencephalic embryos showed delayed turning in one-third of treated mutant crosses and less than a quarter of treated nonmutant crosses. Another one-third of exencephalics, in treated mutant crosses only, had abnormally twisted hindbodies and appeared to be phenocopies of untreated homozygotes. Insulin treatment significantly slowed the rates of embryo turning and neural tube closure but did not affect somite number. Histologically, insulin did not appear to cause cell death, and mitotic index of mesoderm was unaffected. Only exencephalic embryos showed a significant reduction in neurectoderm mitotic index. Insulin caused a reduction in neurectoderm cell proliferation, delay in pattern of turning and delay in neural tube closure to the greatest extent in exencephalic embryos. It was postulated that extensive delays in turning could provide a mechanical basis for the failure of the neural tube to close.

Abnormalities, Drug-Induced↗
PubMed1979

Present and future developments in hearing aid design.

Although hearing aids have shown little outward change in the past decade, the development of new components has produced a steady reduction in size and improvement in performance. The near-perfect electret condenser microphone occupies a mere 50 cubic millimeters and its low vibrational sensitivity permits close packing of components without acoustic feedback problems. The integrated circuit packs a hundred components into each cubic millimeter and has allowed the miniaturization of complex aids while simultaneously boosting performance. Integrated circuits will permit future aids to compensate distorted loudness perception as a function of frequency, and extract speech signals buried in noise. These sophisticated, computerized, hearing aids will demand new evaluation and fitting methods and it is the methodology rather than the technology that will pace their development.

Electronics, Medical↗
PubMedDate not supplied

A regulatory burden.

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Dental Care for Persons with Disabilities↗