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Biomedical subjects

W A Chambers

Publications and source records attributed to W A Chambers.

61 records · Page 4Linked to original sources
PubMed1981

Extradural morphine for pain after surgery.

The effects of 10 mg of morphine sulphate given either extradurally or i.m. for the relief of pain after operation were compared in two randomized double-blind trials in patients undergoing major gynaecological surgery. In the first trial when morphine was given with the local anaesthetic before surgery, extradural administration resulted in significantly longer lasting analgesia: mean 707 min compared with 371 min (i.m.). In the second trial in patients complaining of pain after operation, extradural morphine had a slower onset of action, but longer duration of action compared with i.m. morphine, although the differences were not statistically significant. In this group extradural morphine often failed to provide useful analgesia. The extradural group received significantly less additional morphine (6.75 mg) than did the i.m. group (18.75 mg) in the following 24 h.

Adult↗
PubMed1981

Effect of added epinephrine on spinal anesthesia with lidocaine.

The effect of adding 0.1, 0.2, or 0.3 ml of 1:1000 epinephrine to 1.5 ml of 5% lidocaine in 7.5% dextrose for spinal anesthesia was assessed in 40 patients in a double-blind study. The addition of epinephrine produced little or no clinically useful prolongation of block. There was a small reduction in the speed of decay of nerve block, but this only reached statistical significance with regard to total recovery, which took 40 to 50 minutes longer with the epinephrine-containing solutions. No difference could be seen between the three doses of epinephrine.

Aged↗
PubMedDate not supplied

Ampicillin resistant Haemophilus parainfluenzae endocarditis.

A case of Haemophilus parainfluenzae bacterial endocarditis is described. This is the first reported case of endocarditis caused by ampicillin resistant H parainfluenzae. Resistance was not mediated by a beta lactamase. Ampicillin therapy had not controlled the infection, but a four-week course of chloramphenicol was curative. Several general therapeutic points are discussed.

Adult↗
PubMedDate not supplied

Contact lenses in the visual correction of keratoconus.

A two and one-half year (April 1985-October 1987) retrospective review of all newly referred keratoconus patients was performed to determine the treatment regimen of previously diagnosed "contact lens failures." The records of 48 patients (average age 32 +/- 9.0 years; 24 males, 24 females) were reviewed. Thirty-nine patients had been diagnosed as "contact lens failures" and referred for surgical intervention. Of these 39 patients, seven eyes were excluded from evaluation (four with prior grafts, two cases of unilateral keratoconus, and one with a dense central scar). Of the remaining 71 eyes, 57 (80%) (average keratometry 50.7 +/- 5.1 D, range 43-73) were successfully refit with contact lenses. All obtained a daily wearing time of 12 hours or more and a visual acuity of 20/40 or better--with 87% realizing 20/30 or better. The data suggest that the vast majority of keratoconus patients previously thought to be contact lens intolerant can be successfully refit and achieve excellent visual acuity and prolonged wearing times.

Astigmatism↗