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Biomedical subjects

Viroj Wiwanitkit

Publications and source records attributed to Viroj Wiwanitkit.

At least 127 records · Page 7Linked to original sources
PubMed2004

Bleeding and other presentations in Thai patients with dengue infection.

Dengue infection is a major public health problem, affecting the general population in Southeast Asia. Hematologic aberrations in dengue infection include atypical lymphocytosis, coagulopathy, and predominant thrombocytopenia. Bleeding and other presentations in 30 Thai patients with dengue infection during an endemic season (2003) are presented. A review of the clinical presentation of these patients was performed. All had fever as a chief complaint. The three most common complaints were fever (100%), vomiting (90%), and cough (90%), respectively. Concerning bleeding, only eight cases (26.6%) had signs of bleeding. Those manifestations included petechiae (seven cases, 23.3%) and melena (one case, 3.3%). Skin bleeding (petechiae) due to thrombocytopenia is the most common bleeding manifestation in dengue infection. However, physicians should not overlook bleeding from other less common sites such as the gastrointestinal tract and genitourinary tract.

Dengue↗
PubMed2004

The importance of platelet counts in dengue infection: 35 cases and literature review.

Dengue infection is a major vector-borne disease. The classical form of this infection has an incubation period of 5 to 8 days followed by fever, violent headache, and chills, with rash developing after 3 to 4 days. A summative report on the platelet count and its clinical correlation to duration of fever in 35 Thai children is presented. Most of the subjects visited to the physician with a complaint for fever. Most patients went to see the physician between the 3rd and the 5th day from the onset of fever. There is no significant correlation between platelet count and duration of fever (ANOVA test, p = 0.28). However, there is a trend of increase platelet count in the later days. In addition, an overview on the previous literatures on platelet count and dengue infection is presented.

Dengue↗
PubMed2004

Pineapple juice for digestion of swamp eel viscera for harvesting infective-stage larva of Gnathostoma spp.

Third-stage larvae were used as antigen in the diagnosis of gnathostomiasis in Western blot analysis. Normally, the larvae were obtained from digestion of eel's liver (Fluta alba) by the enzyme pepsin. We used pineapple juice (Ananus comosus) instead of enzyme pepsin in harvesting Gnathostoma spinigerum third-stage larvae. The difference in recovered larvae numbers, between pineapple juice and pepsin, were not statistically significantly different (p>0.05). The larvae from pepsin and pineapple juice digestion were cultivated on BME for 7 days; the survival rates were not significantly different (p>0.05). Thus, pineapple juice is another enzyme of choice for recovering Gnathostoma spinigerum third-stage larvae.

Ananas↗
PubMed2004

Urine phenol levels among Thai police, implications for occupational health.

In this study, we study an at-risk occupation, the police. Forty-five urine samples were obtained from 45 Thai police working close to traffic in an urban area, for analysis of urine phenol levels. The average (mean +/- SD) urine phenol level in these police was 16.94 +/- 11.72 mg/g-Cr. Significantly higher urine phenol levels were found among police who had worked for longer durations (p < 0.05).

Adult↗
PubMed2003

Screening for hemoglobin disorders in Thai pregnant women by England and Frazer's calculation method.

OBJECTIVE: Our objective was to perform a preliminary study screening for hemoglobin disorders among Thai pregnant women using England and Frazer's calculation method. PATIENTS: One hundred and thirty-five pregnant women who receive antenatal laboratory check-up from the Out-Patient Division, King Chulalongkorn Memorial Hospital. METHODS: Endocrine disruptor testing and assessment (EDTA) blood specimens from each patient were analyzed by two methods in order to screen for inherited hemoglobin disorders. Hemoglobin and genotype analysis was set as the confirmation method. Blood indices investigation performed by automated hematology analyzer was set for England and Frazer's calculation method as the screening method. RESULTS: The sensitivity and specificity of the method using England and Frazer's calculation were 92.3 and 100%. False positive and false negative results were 0% and 7.7%. CONCLUSION: England and Frazer's calculation method can be an alternative method that can help screen for hemoglobin E disorders in pregnant women.

Cost-Benefit Analysis↗
PubMed2003

Clinical findings among 62 Thais with cholangiocarcinoma.

Cholangiocarcinoma, a malignancy of the biliary duct system, tends to grow slowly and to infiltrate the walls of the ducts, dissecting along tissue planes and leading to biliary tract obstruction. In a retrospective case review, 62 cases diagnosed with cholangiocarcinoma between January 1997 and December 2001 at the King Chulalongkorn Memorial Hospital in Bangkok were studied. The most commonly observed clinical symptoms and signs were fever (96.8%), abdominal pain (87.1%) and malaise or weakness (83.9%). Fifty-one of the 62 tumours detected were distal extrahepatic (82.3%), seven perihilar (11.3%) and four intrahepatic (6.7%). There was a significant increase in serum bilirubin and marked elevation of serum alkaline phosphatase. Almost half (45.2%) of the patients presented with other pathological conditions, mostly cholangitis (19 cases) resulting from acute biliary tract obstruction and ascites (13 cases). The pathogens detected were similar in cases of cholangitis alone and cholangiocarcinoma. The major risk factor for this cancer in Thailand is believed to be exposure to liver fluke in insufficiently cooked traditional foods. As it is still endemic in Thailand, continuous prevention and surveillance of this public health problem are necessary.

Adult↗
PubMed2003

Platelet parameters in subjects infected with hookworm.

Hookworm is an important intestinal parasite infection with high prevalence in tropical countries. In addition to iron deficiency anaemia, the human hookworm appears to have evolved a number of complementary strategies to overcome the host's haemostatic processes. These include the inhibition of blood coagulation, platelet aggregation and mediator release, and the secretion of fibrinogenolytic enzymes. In this work, we studied the platelets in the subjects with detection of hookworm infection from screening stool examination comparing to those without. One hundred subjects were included, studied for stool parasite and platelet parameters. Of our 100 subjects, hookworms were identified in stools of six cases, giving an infection rate equal to 6%. The platelet parameters of the subjects showed a statistically significant lowering of mean platelet volume (MPV) in the subjects with hookworm infection. Also, we detected a non-significant lower platelet count in subjects with hookworm infections. Of interest, the alteration in platelet size, identified by platelet parameters, has never been documented in the literature. This observation might be a pathological process or might be an accidental finding in our study.

Animals↗