Search PubMed⌕ Search

Biomedical subjects

V Zvara

Publications and source records attributed to V Zvara.

At least 37 records · Page 2Linked to original sources
PubMed1987

Prognosis of patients after retroperitoneal lymphadenectomy for clinical stage I nonseminomatous germ cell tumour of the testis.

A retrospective analysis of patients with the clinical stage I nonseminomatous germ cell tumour of the testis was performed in order to test the reliability of clinical diagnostic methods in assessing the extent of the disease, morbidity, relapse rate, and survival after retroperitoneal lymphadenectomy, and in an effort to pinpoint the risk factors leading to relapse. A total of 69 patients with clinical stage I nonseminomatous germ cell tumours of the testis underwent retroperitoneal lymphadenectomy. Metastases in the retroperitoneal space were found in 8 [11.6%] patients. Immediate postoperative complications were observed in 7.2% of patients. Loss of ejaculation was found in 52.9% of patients after bilateral, and in 21.4% after unilateral retroperitoneal lymphadenectomy. Relapse was noted in 5 out of 61 [8.2%] patients, with the relapse invariably localized in the lungs. Of the 69 patients, 65 [94.2%] are alive, free of signs of the disease at an average 5.4 years since initiation of treatment. The study did not find a correlation between relapse and histologic findings and/or the extent of the germ cell tumour.

Adolescent↗
PubMed1986

Urinary excretion of vitamin C in chronic renal failure and after renal transplantation.

Urinary excretion of vitamin C was investigated in 44 patients with chronic renal diseases and in 25 patients after renal transplantation with various mean glomerular filtration rates. In both groups a hyperbolic relationship was observed between FE vitamin C and CCr. In addition, direct relationships were found between FE vitamin C and FE Na, FEK and FE H2O in both groups. Various chronic renal diseases and treatments had no influence on the investigated relationships. In 16 healthy subjects urinary excretion of sodium during maximal water diuresis did not increase but urinary excretion of vitamin C significantly increased. In 10 patients in the polyuric stage of chronic renal failure without dialysis treatment during Giordano-Giovanetti-Maggiora diet with addition of sodium chloride the urinary excretion of sodium increased but that of vitamin C was not influenced. The results obtained for the biochemical parameters tested suggest that the urinary excretion of vitamin C depends on the urinary excretion of water.

Adult↗
PubMed1986

The role of tumour markers and lymphography in determining clinical stage of non-seminomatous testis tumours.

Findings established by means of tumour markers examination and lymphography were compared with histological findings in retroperitoneal lymph nodes removed during lymphadenectomy. Overall accuracy of tumour markers was 70.1%, sensitivity was 71.4% and specificity was 67.9%. Overall accuracy of lymphography was 79.4%, sensitivity was 80.7% and specificity was 77.5%. Combined results of tumour markers and lymphography showed overall accuracy 73.1%, sensitivity 93% and specificity 37.5%. Since neither the results of tumour markers examination, nor lymphography are sufficiently sensitive in order to determine exactly the presence of metastases in regional lymph nodes, retroperitoneal lymphadenectomy must be considered in the present for a method which is not only of therapeutic, but also of diagnostic and prognostic importance.

Chorionic Gonadotropin↗
PubMed1986

Long-term results of treatment of urethral strictures by transpubic urethroplasty.

Intrapelvic ruptures of membraneous urethra connected with pelvis fractures lead, as a rule, to strictures. Relative inaccessibility of these strictures above diaphragma urogenitale and behind symphysis makes their surgical treatment difficult. Transpubic approach with removal of wedge of pubic bones enables a direct approach to stricture and its modification under sight control. Technique of transpubic approach is described and long-term results obtained in 10 patients being 29-54 months after operation are evaluated. In one patient urinary continence in a sense of stress incontinence was disturbed, in one patient impotence occurred and one patient had disturbed gait.

Adolescent↗
PubMed1986

Treatment of retrocaval ureter.

Retrocaval ureter is a developmental anomaly of the course of the ureter in relation to the inferior vena cava. In spite of the fact the pathophysiological consequences of this anomaly are very serious, clinical manifestations are relatively poor. Experience with the management of this disorder in our 4 patients justifies the therapy we applied. It involves resection of a part of the ureter running behind the inferior vena cava, transposition of the ureter and subsequent end-to-end anastomosis of both parts of the ureter or of the ureter directly with the pelvis. The results verified at postoperative check-up examinations were very good, demonstrating the correctness of the tactics and procedure used.

Adolescent↗
PubMed1986

Occurrence of adenocarcinoma in the colon sigmoideum following Maydl's operation for urinary bladder exstrophy.

Two cases of colonic adenocarcinoma appearing 44 and 25 years, respectively, following an operation for urinary bladder exstrophy done according to Maydl are reported. A need for regular controls of patients with inner urine derivations has been emphasized. In the case of a suspected tumour it is necessary to alter the inner derivation to an outer one and also a resection of the colon at the site of the urinary bladder trigone is required. The Czech surgeon Karel Maydl was the first to implant the trigone of a splitted urinary bladder into the colon sigmoideum in 1892. This type of operation is used even today by several European urologists with excellent long-term results with respect to the preservation of an intact ureterovasical passage which prevents the reflux of the intestinal contents into the ureter, and also prevents the formation of strictures in the terminal parts of the ureter. In two patients who had been living for 25 and 44 years since they were operated on for urinary bladder exstrophy according to Maydl, a colonic adenocarcinoma was diagnosed. The tumour directly affected the implanted trigone wall and also involved the surrounding parts of the colon wall.

Adenocarcinoma↗
PubMed1986

Formation of calcium oxalate urolithiasis in experiment and its inhibition by pyridoxine and magnesium.

Possibility of application of experimental model of calcium oxalate urolithiasis to the study of some medicament actions useful in prevention of calcium oxalate urolithiasis in men has been examined in animal experiments. Inhibition effects of pyridoxine and magnesium in formation of calcium oxalate stone formation have been proved. Administration of pyridoxine and/or magnesium to experimental animals inhibited formation of incrustations on renal papillae. Administration of nothing but magnesium lowered considerably also frequency of nephrocalcinosis occurrence. Good reproducibility of applied model of calcium oxalate urolithiasis creates conditions for further experimental study of this kind of urolithiasis. In the previous series of experiments (4) we tiped out an experimental model of calcium oxalate urolithiasis in animals well reproducible in our conditions. In the following period we were interested, whether the created model can be applied to verification of efficiency and further study of some medicaments affecting this kind of urolithiasis. At present, pyridoxine and magnesium are mode widely used for prevention of calcium oxalate urolithiasis in the clinical practice. Therefore, we decided to use the possibilities of the evaluated experimental model for the study of their inhibition effects. The results of experiments are presented in this paper.

Animals↗
PubMed1985

Transient impairment of tubular reabsorption of calcium (TRCa) after renal transplantation.

TRCa calculations (using the values of plasma ultrafiltrable Ca and urinary Ca) revealed impaired renal Ca handling in 14/32 patients with transplanted kidneys. TRCa improved in relationship with the increment in renal transplant function, and was within the normal range in all patients with GFR above 50 ml/min. There was a positive correlation between serum Ca and TRCa; hypocalcaemia was found in 9 patients and hypercalcaemia in 3. In the majority of hypocalcaemic patients TRCa impairment was discovered, however, pathologically decreased serum Ca values were found in only one half of the patients with impaired TRCa. In most hypocalcaemic patients the concomitant renal transplant insufficiency, hyperphosphataemia and/or insufficient dietary Ca intake seemed likely to have contributed to serum Ca depletion.

Absorption↗
PubMed1985

Urolithiasis in childhood.

On the basis of epidemiological study in closed children's population of Bratislava (350 000 inhabitants, out of them 70 000 children) the conclusions about falling urolithiasis incidence in children of urban population are drawn. Analysis and clinical evaluations of 287 children's patients with urolithiasis shows that in solitary calculi (in partial casts as well) the results of treatment are very good, repeated recurrences are rare. The results are considerably worse in multiple and great staghorn stones. The importance of first surgical treatment, in which all stones should be removed, as well as principles of both general and specific treatment in relationship with stone composition and metabolic disturbances are stressed.

Adolescent↗
PubMed1985

Prognosis of urolithiasis and nephrocalcinosis in hypomagnesemia.

In 78 patients with hypomagnesemia in urolithiasis the clinical course of disease was established in relation to therapy and dynamics of changes of serum magnesium levels. Almost 70% of patients had multiple, bilateral or recurrent nephrolithiasis or nephrocalcinosis. 70% of patients had Ca-oxalate stones or bilateral nephrocalcinosis. In 52% of patients a long-term magnesium supplementation was necessary. Significant progress of nephrolithiasis and nephrocalcinosis was observed in 80% of patients with permanent hypomagnesemia and in 4% of patients with normalization of serum magnesium level. Three of 15 patients with hypomagnesemia and progress of disease were transplanted a kidney and two were treated by hemodialysis. All five patients with renal failure had bilateral nephrocalcinosis, in three of them familiar occurrence of nephrolithiasis and hypomagnesemia was found.

Adolescent↗