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Biomedical subjects

V Wynn

Publications and source records attributed to V Wynn.

At least 127 records · Page 7Linked to original sources
PubMed1973

Studies of carbohydrate and lipid metabolism in women developing hypertension on oral contraceptives.

Metabolic studies in 100 women developing hypertension on combined oestrogen-progestogen oral contraceptives have been compared with similar studies in normotensive women on oral contraceptives, matched for age and duration of contraceptive use, and in women not taking contraceptives.The metabolic changes known to be induced by oral contraceptives-impaired glucose tolerance, elevated blood pyruvate levels, and raised serum lipid concentrations-were found to be exaggerated in the matched hypertensive group, largely due to pronounced abnormalities in 33 subjects with diastolic blood pressures over 110 mm Hg.Women developing severe hypertension were older, more obese, and of higher parity than those with mild hypertension and there was a high incidence of previous toxaemia of pregnancy in the hypertensive group.The results show that in women on oral contraceptives changes in blood pressure and in metabolic functions tend to be correlated with one another, and are consistent with the hypothesis that oral contraception induces a primary biochemical effect whose expression in the individual is determined by intrinsic factors including genetic constitution, age, weight, and parity.

Adult↗
PubMed1972

The relation of growth hormone to altered carbohydrate metabolism in women taking oral contraceptives.

Oral glucose tolerance tests were performed on a group of women before and during oral contraceptive administration and the plasma glucose, insulin, and growth hormone levels were studied. A significant impairment of glucose tolerance and an altered insulin response were observed in women taking oral contraceptives. The women had higher plasma growth hormone levels in the fasting state but this is not of primary aetiological significance in the development of altered carbohydrate metabolism.

Adult↗
PubMed1970

Effects of obesity, glucocorticoid, and oral contraceptive therapy on plasma glucose and blood pyruvate levels.

THE PLASMA GLUCOSE AND BLOOD PYRUVATE LEVELS WERE DETERMINED AFTER ORAL GLUCOSE TOLERANCE TEST IN SIX GROUPS OF WOMEN: non-obese and obese controls and in non-obese and obese women receiving glucocorticoid or oral contraceptive therapy. The mean fasting plasma glucose level was similar in all groups, but glucose tolerance was impaired in the obese controls, non-obese women on oral contraceptives or being treated with glucocorticoids, and appreciably impaired in the obese oral contraceptive and glucocorticoid groups compared with mean levels in non-obese subjects of the same groups. Obesity was associated with abnormally raised blood pyruvate levels in response to a glucose tolerance test in all groups. Striking similarities were observed between the responses of the plasma glucose and blood pyruvate levels to glucose tolerance tests in the obese control and non-obese oral contraceptive and non-obese glucocorticoid-treated groups. It is suggested that these abnormalities result from a common mechanism-namely, glucocorticoid excess.

Adult↗
PubMed1970

Pancreatic islet cell tumour with watery diarrhoea and hypokalaemia.

A further patient with watery diarrhoea and hypokalaemia in association with a non-beta islet cell tumour of the pancreas is reported. The mechanism by which fluid and electrolyte losses are produced is discussed and cases previously reported are reviewed.

Adenoma, Islet Cell↗