Search PubMed⌕ Search

Biomedical subjects

V Wright

Publications and source records attributed to V Wright.

At least 235 records · Page 13Linked to original sources
PubMed1980

Rheumajecta in the treatment of rheumatoid arthritis.

A double-blind controlled trial of Rheumajecta in rheumatoid arthritis demonstrated lack of effect of this compound and unacceptable side-effects. It was not felt ethically justifiable to complete the trial.

Anti-Inflammatory Agents↗
PubMed1980

Measurement of temperature in the arthritic hand.

Two simple and relatively inexpensive thermographic techniques have been studied as possible methods for quantifying change in inflammation, either spontaneous or drug induced, in the rheumatoid hand. Crystal thermography plates were found to be of no value. An infra-red medical thermometer provided reproducible results, providing full precautions were observed. The fall in temperature produced at individual joints by local steroid injection, whilst consistent, fell within the observed temperature variation of the untreated rheumatoid hand.

Arthritis, Rheumatoid↗
PubMed1980

Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease.

A study of 59 patients with definite ankylosing spondylitis and 41 comparable hospital outpatients with fractures has been undertaken to determine if the presence of faecal Klebsiella aerogenes is related to clinical activity of the spinal disease and its extraspinal features. The frequencies of fecal K. aerogenes were similar in both patients and controls and were not significantly related to spinal disease activity. Careful inquiry about antibiotic treatment, dietary habits, and hospitalisation did not significantly influence the results. A significant association was found between the presence of faecal K. aerogenes and both acute non-granulomatous anterior uveitis (P less than 0.01) and peripheral synovitis in HLA B27 positive patients (P less than 0.05). These results suggest that K. aerogenes may have an aetiological role in the development of non-granulomatous anterior uveitis and peripheral arthritis in patients with ankylosing spondylitis but do not lend support to this organism having such a role in the spinal disease itself.

Acute Disease↗
PubMed1980

A comparison of clinical assessments of disease activity in rheumatoid arthritis.

Six clinical assessments of disease activity, including a new summated change scale (SCS), have been compared in a group of 30 patients with rheumatoid arthritis seen on 8 separate occasions during their first 6 months of therapy with either D-penicillamine or hydroxychloroquine. Articular index and grip strength correlate best with erythrocyte sedimentation rate and C-reactive protein, pain score and early morning stiffness less well, and summated change score and joint circumference least well. Articular index and grip strength also correlated well with the other clinical parameters and are therefore judged to be the best clinical indices of change in treatment with these drugs.

Arthritis, Rheumatoid↗
PubMed1980

Seronegative pauciarticular arthritis and HLA B27.

Twenty-six patients with a pauciarticular arthritis have been studied clinically, radiologically and with histocompatibility typing. An increased frequency of HLA B27 was found (p = 1.87 x 10(-12)). Low back and buttock pain, Achilles tendinitis and dactylitis of the toes were more frequent in HLA-B27 positive patients. It is suggested that histocompatibility testing may be of some value in diagnosis and in the investigation of the possible 'reactive' nature of this type of arthritis.

Adolescent↗
PubMed1980

A biochemical comparison of alclofenac and D-penicillamine in rheumatoid arthritis.

In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1980

Discriminatory indices of response of patients with rheumatoid arthritis treated with D-penicillamine.

A long-term study is being undertaken to classify drugs used as specific agents in the treatment of rheumatoid arthritis in terms of their effects on biochemical and clinical characteristics of the disease. In particular is hoped to establish those indices which are most relevant to the response of RA to treatment. Fifteen patients were treated with D-penicillamine after an initial period of 2 weeks on aspirin alone, when the baseline investigations were made. The dose of penicillamine was increased gradually to a maximum of 500 mg a day over the period of 6 months, and changes in 8 clinical and 25 laboratory indices were measured on 8 separate occasions in the 6-month period. Marked clinical improvement took place, and this was mirrored by changes in a wide range of biochemical parametaers. ESR and C-reactive protein were shown to be the most suitable indices of disease improvement with penicillamine treatment.

Adult↗
PubMed1980

Joint laxity and osteoarthrosis: a radiological survey of female physical education specialists.

Three hundred and sixty-four female specialist teachers of physical education who qualified between 1935 and 1950 agreed to have x-rays of the lumbar spine, hips and knees. Fifty-two has osteoarthrosis of the hip, 65 osteoarthrosis of the knee and 221 degenerative change in the spine. Overall osteoarthrosis of the knee was significantly less common than in a comparable sample from the general population (p < 0.001), severe or moderate osteoarthrosis being equally common in both groups but minor in minimal osteoarthrosis being much less common in the teachers. There was no significant difference in the prevalence of osteoarthrosis of the hip between the two populations though severe osteoarthrosis of the hip was slightly more common in the teachers.

Bone Diseases↗
PubMed1980

Is generalized joint laxity a factor in spondylolisthesis?

A postal questionnaire designed to assess joint laxity was sent to 364 specialist female teachers of physical education who had participated in a radiological survey on the lumbar spine. 295 replied and in this group the prevalence of spondylolisthesis was 4%. Although statistical analysis failed to demonstrate a significant association between generalized joint laxity, measured with a simple scoring system, and radiological spondylolisthesis, spondylolisthesis was found to correlate with known associations of joint laxity such as flat feet. Adults with spondylolisthesis considered themselves more supple in youth than adults without spondylolisthesis.

Adult↗
PubMed1980

The "total solution" for total hip replacement surgery.

Despite the great alleviation in suffering produced by total hip replacement surgery, some caution is indicated. Many of the patients who undergo surgery still present problems some time after the operation and for which there is no obvious or adequate medical or engineering explanation. It is therefore suggested that no report on such surgery is complete without regard for patients' expectations, patients' satisfaction and without common agreement by surgeons on what can be expected from the operation. This paper highlights the importance of patients' and surgeons' expectations and the need for all to be aware of the influence of such expectations. If also suggests that surgeons rely heavily on their own judgements as to what state patients should be in prior to surgery. If the solution for such a radical measure is to be total for the patient, then patients' feelings and judgements should also be considered.

Aged↗
PubMed1980

A comparative study of benoxaprofen and indomethacin in ankylosing spondylitis.

Benoxaprofen (600 mg once daily) has been compared to indomethacin (25 mg 3 times daily) in a double-blind crossover study of 20 patients with active ankylosing spondylitis (AS). The clinical improvement was comparable with both drugs; 6 patients preferred benoxaprofen and 7 patients indomethacin. Although 2 patients discontinued benoxaprofen because of lack of effect, no upper gastrointestinal side effects were reported with this drug. Benoxaprofen is an alternative to indomethacin in the treatment of AS.

Adolescent↗
PubMed1980

Dose-range studies of benoxaprofen compared with placebo in patients with active rheumatoid arthritis.

The new nonsteroidal antiinflammatory drug benoxaprofen was compared with placebo in separate double-blind crossover studies in patients with active rheumatoid arthritis given 400 mg, 600 mg, or 800 mg a day. Benoxaprofen was significantly better than placebo at all doses studied. The 800 mg dose was the most effective but there were slightly more gastrointestinal side effects with this dose. The 600 mg dose was more effective than the 400 mg dose with an acceptably low incidence of side effects at both these doses. For most patients, 600 mg once daily will probably be the usual dose of the drug, but some will need the higher dose to 800 mg, while the condition of others may be satisfactorily controlled with just 400 mg daily.

Adolescent↗