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Biomedical subjects

V Wright

Publications and source records attributed to V Wright.

At least 199 records · Page 11Linked to original sources
PubMed1983

Psoriatic arthritis.

Explore the source record for details and available documents.

Anti-Inflammatory Agents↗
PubMed1983

A double blind study of antrafenine, naproxen and placebo in osteoarthrosis.

Antrafenine, a new non-narcotic analgesic, has been compared at a dose of 600 mg/day to naproxen 500 mg/day and placebo in a double blind three way cross-over study on 36 patients with osteoarthrosis of the hip and/or knee. There was significant improvement with both active drugs. There was no significant difference between the two active drugs. Patients' preference at the end of the study was antrafenine 7, naproxen 10, placebo 2, no preference 9.3 patients withdrew because of concomitant illness; 2 patients withdrew because of lack of efficacy in the placebo period; 3 patients failed to attend clinic. Antrafenine is more efficacious than placebo in the treatment of osteoarthrosis of the hip and/or knee, and at the doses tested, is of comparable potency to naproxen.

Bone Diseases↗
PubMed1982

A pharmacological and clinical comparison of prednisolone and betamethasone in rheumatoid arthritis.

1. Two oral corticosteroids, prednisolone (8 mg/day) and betamethasone (1 mg/day) have been compared in terms of efficacy and adrenal suppressive activity when used in chronic oral dosage in rheumatoid arthritis. 2. 20 patients were entered to a single blind crossover study receiving each drug for a two-week period. Clinical and laboratory assessments were performed. 3. At this dosage there was no significant difference between any of the clinical parameters assessed for either drug though patient preference was 13 for prednisolone and 7 for betamethasone. 4. At this dosage adrenal suppression was not equivalent, being significantly more marked with betamethasone. 5. The results suggest that prednisolone is the drug of choice for chronic dosage.

Adult↗
PubMed1982

The run-in period in trial design: a comparison of two non-steroidal anti-inflammatory agents in psoriatic arthropathy.

Psoriatic arthropathy is a relatively uncommon arthritis that exists in a wide variety of clinical forms. These two features of the disease cause problems in the design of clinical trials. In a comparison of two non-steroidal anti-inflammatory agents in this condition we attempted to overcome the difficulties by using a run-in period during which the dosage of one of the trial drugs was adjusted to suit the individual patient. After two weeks on indomethacin (75 mg or 150 mg/day) patients were allocated to four-week periods of indomethacin in the chosen dosage or diclofenac (75 mg or 150 mg/day) in a double-blind randomized crossover trial that used double dummy packaging. Of the 35 patients that entered the study, 19 completed both study groups. No significant differences were observed between the clinical improvements due to both drugs during the course of the study. In general more side-effects were seen during indomethacin treatment, though the study design precluded exact comparison. In a study biased against diclofenac, patient preference was 9/19 for indomethacin, 4/19 for diclofenac and 7/19 expressing no choice. Advantages and disadvantages of the study design are discussed.

Adult↗
PubMed1982

Naproxen and indomethacin in periarthritis of the shoulder.

Forty-one patients with periarthritis of the shoulder were entered into a double-blind, parallel comparison of naproxen and indomethacin. Both drugs were given twice daily, naproxen 250 mg in the morning and 500 mg at night and indomethacin 50 mg b.d. Twenty patients received naproxen and 21 received indomethacin. Patients were treated for four weeks. Both drugs significantly reduced pain and patients subjective impression of shoulder restriction, but had little significant effect on objective measurements of mobility. Fourteen patients from the naproxen group and 16 patients from the indomethacin group reported side-effects, the most common being nausea and headache. Three patients stopped naproxen and five patients stopped indomethacin because of side-effects. In conclusion, both drugs were equally effective in treating the pain of periarthritis of the shoulder but did little to change the partial loss of movement associated with the disorder.

Clinical Trials as Topic↗
PubMed1982

A functional study of the rheumatoid elbow.

A clinical and functional study of rheumatoid elbows has been done to discover the magnitude and frequency of disabilities caused by elbow problems. Pain and weakness were found to affect all activities which were tested, with adjacent joint involvement, flexion deformity, and lack of supination causing significant disability. Instability was not a frequent problem. The frequency of functional disabilities, linked to severe pain, suggests that the development of an elbow joint replacement would be worthwhile.

Arthritis, Rheumatoid↗
PubMed1982

A sequential study of the relationship between faecal Klebsiella aerogenes and the common clinical manifestations of ankylosing spondylitis.

An 8-month sequential study at 4-weekly intervals of faecal Klebsiella aerogenes and clinical activity of ankylosing spondylitis is described. Similar frequencies of faecal K. aerogenes were found in the 44 patients and 36 healthy controls studied. Eighteen patients on 19 occasions had K. aerogenes cultured from their faeces, when the preceding specimen had been negative. Six (31.6%) of these occasions were associated with a deterioration in clinical state compared with a similar deterioration associated with only 17 (9.8%) of the remaining 174 faecal culture sequences (p less than 0.02). These results suggest that clinical deterioration in ankylosing spondylitis may be associated with the acquisition of faecal K. aerogenes.

Acute Disease↗
PubMed1982

Changes in joint laxity occurring during pregnancy.

We have studied changes in peripheral joint laxity occurring during pregnancy in 68 females using both the finger hyperextensometer to quantify laxity at the metacarpophalangeal joint of the index finger and Beighton et al.'s modification of the Carter and Wilkinson scoring system. Although the latter system recorded no change, the more sensitive hyperextensometer demonstrated a significant increase in joint laxity during the last trimester of pregnancy (0.02 greater than p greater than 0.01) over the readings from the same individuals after parturition. When primigravidae and multigravidae were compared, a highly significant increase in laxity was found in women having their second baby over those having their first (0.01 greater than p greater than 0.001), though no further increase in laxity occurred in subsequent pregnancies.

Adult↗
PubMed1982

How long should we talk to patients? A study in doctor-patient communication.

The 13 questions to which 173 rheumatic outpatients most frequently wished to know the answer were made the basis of a structured interview. Two lengths of interview were conducted in a controlled trial (short being of 2 minutes' duration, long ranging from 4 to 11 minutes). Sixty patients referred directly from their general practitioners, and not being in any of the remedial professions, were randomly assigned to one of the 2 groups. They were tested by an independent observer immediately after interview, and one month later at their return appointment, by means of a questionnaire that covered the 13 items of information given to all the patients. The longer interview resulted in significantly more information being retained. Of individual questions only 3 scored significantly better with the longer interview--that about the reasons for x-rays immediately after interview, and the role of heredity and the place of rest at delayed recall.

Adolescent↗
PubMed1982

Comparison of serum 1,25-dihydroxycholecalciferol concentrations in rheumatoid arthritis and osteoarthrosis.

We have previously compared 25-hydroxycholecalciferol levels in the serum of patients with osteoarthrosis and rheumatoid arthritis, finding no significant difference between the circulating levels of this hormone. We have now estimated 1,25-dihydroxycholecalciferol levels on stored sera from the same groups of patients and found no significant difference in the levels of this hormone between the 2 groups. The osteopenia that distinguishes rheumatoid arthritis from osteoarthrosis is not the result of altered levels of systemic 25OHD3 or of 1,25(OH)2D3. Local factors may be more important in its pathogenesis.

Aged↗
PubMed1982

A comparison between gastrointestinal blood loss caused by tilcotil (Ro 12-0068) and aspirin in normal volunteers.

An open crossover study was carried out in 6 normal volunteers to measure faecal blood loss caused by tilcotil (Ro 12-0068), a new anti-inflammatory drug, compared with that caused by enteric-coated aspirin. Subjects were allocated at random to receive either single doses of 20 mg tilcotil daily or 900 mg aspirin 4-times daily, reducing to a maximum tolerated dose, over a period of 2 weeks before being crossed over to the alternative medication for a further 2 weeks. Faecal specimens passed during 4 consecutive days in a run-in-period of 1 week, in each treatment period, and in the 2 weeks after the finish of drug therapy were analyzed for blood using a radioactive labelling method. The results showed that faecal blood loss was lower and it did not produce any haematological or biochemical abnormalities or any increase in urinary N-acetyl-beta-glucosaminidase activity indicative of renal damage. It is suggested that the method described provides a simple and reliable means of comparing faecal blood loss with different anti-inflammatory drugs.

Acetylglucosaminidase↗
PubMed1982

Mobility in the elderly: the problems of arthritis.

Arthritis is a major cause of severe disability in the elderly, restricting mobility to a considerable extent with consequent adverse effects on the patient's quality of life. Whilst drug therapy and surgery can help to relieve much of the discomfort and pain, more thought and attention must be paid to the problems in the home and community which affect the patient's mobility. The results of surveys carried out in arthritic and control subjects living in an urban environment are reviewed and discussed to highlight some of the more important problems and possible remedies.

Aged↗