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Biomedical subjects

V Wahn

Publications and source records attributed to V Wahn.

150 records · Page 9Linked to original sources
PubMedDate not supplied

[Polysaccharide specific humoral immunodeficiency in ectodermal dysplasia. Case report of a boy with two affected brothers].

We report a now three year old male patient with ectodermal dysplasia and a polysaccharide specific humoral immunodeficiency. Immunological investigations showed compromised production of IgA, IgM, and IgG2. Isohaemagglutinins still were not detectable at the age of three years. Repeated vaccination with polyvalent pneumococcal polysaccharide vaccine did not result in production of specific antibodies. Two brothers showed clinical signs of ectodermal dysplasia. The elder brother died from pneumococcal sepsis at the age of 3 years. The younger brother suffers from chronic inflammatory gastrointestinal disease with ulcerations in all parts of the gastrointestinal system. Thus, a possible association between polysaccharide specific humoral immunodeficiency and ectodermal dysplasia may be considered.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Peripartal monitoring of an HTLV III-infected, heroin-dependent pregnant patient].

In the past the acquired immune deficiency syndrome (AIDS) could be mainly observed in homosexual and drug addicted persons. But at present one has to deal with this problem in obstetrics as well. In this paper a report is given on the late pregnancy and delivery in a heroin addicted gravida with positive HTLV III antibodies. We describe the useful tests to characterize the immunologic status of the patient and give recommendations for the clinical management of pregnancy and delivery.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[AIDS in a child with a LAV/HTLV-III infected mother].

The clinical course of AIDS in a child of a HTLV III virus infected drug addicted mother is reported. Aged 7 month the baby died from Pneumocystis carinii pneumonia. The clinical course prior to the final lethal infection was remarkably uneventful. Immunological controls revealed strikingly high immunoglobulin values, whereas only minor changes of cellular immunity were observed. At birth the baby had HTLV III antibodies as her mother, which dropped during the course of the disease to borderline values.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Acute lethal necrotising pancreatitis in childhood systemic lupus erythematosus--possible toxicity of immunosuppressive therapy.

We report on a 16 year old girl with a three-year history of systemic lupus erythematosus who developed a case of acute lethal haemorrhagic pancreatitis. She presented with high grade fever, skin rash, malaise, and arthralgias. Laboratory lupus activity parameters were markedly elevated. In the absence of renal, pulmonary, cardiac or cerebral involvement, our patient developed pancreatitis leading to pancreatogenic shock. Until 14 days before the onset of pancreatitis, the patient's medications included prednisolone, azathioprine and methotrexate. At autopsy, no autoimmune vasculitis was found in the affected pancreatic tissue. Therefore, an etiologic role of combination therapy had to be considered. Whereas methotrexate has never been reported to be linked to pancreatitis, a few publications describing prednisolone and azathioprine in connection with pancreatitis do exist. Thus, if pancreatitis is not just termed idiopathic, it must be attributed to a combination regimen of drugs including methotrexate. A review of the literature shows that pancreatitis in SLE is rare and has never been associated with methotrexate therapy before.

Acute Disease↗