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Biomedical subjects

V Wagner

Publications and source records attributed to V Wagner.

At least 37 records · Page 2Linked to original sources
PubMed1995

Acute myocardial infarction in Oklahoma: are we different?

Data regarding 787 patients admitted to Saint Francis Hospital in Tulsa, Oklahoma, with acute myocardial infarction (MI) were analyzed to determine circadian variation and to assess demographic and anatomic characteristics. The study population consisted of 634 men (81%) and 153 women (19%). This cohort displayed a circadian rhythm that nearly duplicated a previously published national data base. As was seen nationally, our patients had a peak incidence between 6 AM and noon. Of the total population, 448 patients had acute cardiac catheterization allowing definition of the infarct vessel. The majority of myocardial infarctions were from right coronary artery occlusions. Men were more likely than women to have an anterior MI. Both men and women were more likely to have an inferior MI if they were less than 65 years of age, though this was more pronounced for women. As the population aged, they were more likely to have an anterior myocardial infarction.

Adult↗
PubMed1994

Application of polymorphic DNA sequences to differentiate the origin of decomposed bovine meat.

Two bovine meat samples were analysed although the samples were already in a state of advanced decomposition. The isolated DNA was extremely degraded and not suitable for conventional DNA fingerprinting (profiling), thus the polymerase chain reaction (PCR) was applied to screen for a Y-chromosome specific fragment and the loci of the two milk proteins kappa-casein and beta-lactoglobulin. Both samples contained Y-chromosome specific DNA and the kappa-casein genotype AA but they differed at the beta-lactoglobulin locus (BB versus AB). Thus a different origin (carcass) could be verified for the two samples and a subject was exonerated from a case of meat larceny.

Animals↗
PubMed1991

An epidemiologic-immunological inquiry into the incidence of altered immunity in children of school age.

The authors examined 536 children 10 years of age to evaluate their immune status and the development of allergies and recurrent respiratory inflammations. Altered resistance was found in as many as 47% of children, pollen allergy and atopic eczema in at least 10.5%, habitual rhinitis in 15.2%, asthma in 3.5% and recurrent inflammatory infections in 13.1%. A higher rate of alterations was found where environmental conditions were deteriorated. Elevated IgE, changes in IgG, IgA and IgM as well as increased levels of acute phase proteins suggest a relationship between the degree of immune impairment and clinical manifestations. Our results imply there are large numbers of children with altered immunity and point to the fact that in common practice only 14% of them are attended to by the clinical immunologist and thus receive causal treatment. It is therefore concluded that, in line with the expansion of noxious factors which accompany our civilization, more attention should be given to the development of immunity in the young population.

Child↗
PubMed1990

The effect of oral midazolam on anxiety of preschool children during laceration repair.

Preschool age children often experience marked anxiety and physical pain during laceration repair. Locally infiltrated anesthetics or topical tetracaine, adrenaline, and cocaine (TAC) usually control the physical pain but have little or no effect on anxiety. Midazolam is a short-acting benzodiazepine with anxiolytic, hypnotic, and antegrade amnestic effects. In a double-blind, randomized clinical trial, we evaluated the efficacy of midazolam in alleviating anxiety during laceration repair in children less than 6 years old. On admission to the emergency department, anxiety level was determined on a scale of 1 to 4 based on a predetermined behavior criteria. Patients with high anxiety level (3 or 4) received a single oral dose of either midazolam (0.2 mg/kg) or placebo. The anxiolytic effect of midazolam was considered adequate if the anxiety level decreased two or more points (from 4 to less than or equal to 2 or from 3 to 1) during laceration repair. In the midazolam group (30), 70% of the children had a two-point or more decrease in anxiety level compared with 12% in the placebo group (25) (P less than .0001). No respiratory depression or other complications were noted in the midazolam group. We conclude that a single oral dose of midazolam (0.2 mg/kg) is a safe and effective treatment for alleviating anxiety in children less than 6 years old during laceration repair in the ED.

Administration, Oral↗
PubMed1990

Immunological profiles in workers occupationally exposed to inorganic mercury.

Forty-one male mercury-exposed workers were examined for the serum concentration levels of immunoglobulins (IgG, IgA, IgM), alpha-1-antitrypsin (A1AT), alpha-2-macroglobulin (A2M), ceruloplasmin (CPL) and orosomucoid (ORO). In the period preceding this investigation the mercury concentrations in workplace air ranged from 0.106 to 0.783 mg.m-3, the range of urinary mercury concentrations was from 0.029 to 0.545 mg.1(-1). All but two (IgG and A1AT) of the immune parameters tested were at the levels that were evidently higher than those found in a control group of 55 workers matched by age who lived in a relatively clean area. The percentage of individuals with no value out of the range of normal physiological limits was in the controls almost 80%, in the exposed 36.6% only. These findings confirm the literature data which show that an inhalation exposure to inorganic mercury may evidently have a stimulating effect on some serum proteins in humans.

Analysis of Variance↗
PubMed1990

Potentially fatal hereditary angioedema: a review and case report.

Hereditary angioedema is a disease based upon a biochemical deficiency which may result in sudden and unexpected death principally from respiratory distress due to swelling of the pharyngeal tissues. Dental treatment is not an uncommon initiator of such edema. To perform dental care safely, it is necessary to understand the etiology, diagnosis, and treatment of the condition. This article presents a review of these features, and indicates via a case report how knowledge of them was essential in conducting safe, effective and efficient dental treatment.

Angioedema↗
PubMed1990

Efficacy of tetracaine-adrenaline-cocaine topical anesthetic without tetracaine for facial laceration repair in children.

To determine whether the tetracaine component traditionally used in tetracaine-adrenaline-cocaine (TAC) is necessary to obtain effective topical anesthesia, a prospective study was performed to compare TAC and adrenaline-cocaine preparations for the repair of facial lacerations in children. Physicians were "blind" to which preparation was being used. Of 55 patients studied, 24 received TAC (103 sutures placed) and 31 received adrenaline-cocaine (151 sutures placed). The anesthetic efficacy of each preparation was approximately 95%; there were no adverse reactions related to administration of either medication or complications of wound healing noted in either group. The tetracaine component of TAC is superfluous for obtaining topical anesthesia of minor dermal lacerations of the face in children. The TAC formulation can be simplified by omitting tetracaine without compromising anesthetic efficacy.

Anesthetics, Local↗
PubMed1990

Immunoglobulins and some serum proteins in children with altered resistance coming from areas with variously polluted atmosphere.

In four areas with different types of atmospheric pollution 534 children of school age were examined for serum immunoglobulins (IgG, IgA, IgM and IgE), saliva IgA (sIgA), lysozymes (LYS) and acute phase reactants (alfa-l-antitrypsin - A1AT, alfa-2-macroglobulin -A2M, ceruloplasmin -CPL, transferrin - TRF). The children were divided into two groups: those with altered resistance (AR) comprising allergoses of all types and recurrent or persistent infections and those without the above health problems, i.e. healthy (H). There were more children with AR in areas with higher atmospheric pollution than in control areas. The frequency of AR was higher among boys than among girls. In the control area BN, a number of parameters in the AR group differed significantly from those in the H group. In areas with substantial atmospheric pollution these differences were generally less pronounced. Significant differences were found between the control and polluted areas in many indicators. In the area KO characterized by an intermediate degree of industrial pollution the means of the tested parameters were habitually elevated, whereas in the heavily polluted areas they were decreased. The most sensitive tests for evaluating differences between the areas were the levels of A1AT, LYS, and IgE, while the variations of sIgA, sLYS and CPL were less pronounced.

Air Pollution↗
PubMed1989

Restriction site mapping of adenovirus types 9 and 15 and genome types of intermediate adenovirus 15/H9.

Physical maps were established for seven genome types of the intermediate adenovirus (AV) 15/H9 and for the serologically related prototypes AV15 and 9 using the enzymes BamHI, BglII, and HindIII. The polarity of the fragment order was determined by hybridization with known AV2 fragments. AV15/H9 strains showed more restriction sites in common with AV9 than with AV15. The results are consistent with the hypothesis that intermediate AV15/H9 strains have emerged by recombination.

Adenoviruses, Human↗