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V W Fischer

Publications and source records attributed to V W Fischer.

56 records · Page 4Linked to original sources

cAMP activity and isoproterenol-induced myocardial injury in rats.

Isoproterenol-induced myocardial necrosis (ISO-MN) was obviated by the cardioselective beta-blocker, practolol, suggesting that ISO-MN is caused by specific activation of myocardial beta-adrenergic receptors. Because cAMP is the "second messenger" in such activation, enhanced activity of cAMP should aggravate ISO-MN. Pretreatment of rats with bretylium in various amounts, elicited no ill effects but enhanced the effects of ISO on the cAMP activity and also intensified the ISO-induced structural changes in the myocardium.

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