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Biomedical subjects

V Vuković

Publications and source records attributed to V Vuković.

At least 19 recordsLinked to original sources
PubMed2001

Polymorphism of apoprotein E (APOE), methylenetetrahydrofolate reductase (MTHFR) and paraoxonase (PON1) genes in patients with cerebrovascular disease.

Although controversial, data on the genetic polymorphism of apoprotein E (APOE), methylenetetrahydrofolate (MTHFR) and paraoxonase (PON1) genes implicate their role in the development of cerebrovascular disease. The aim of this study was to assess the association of polymorphism of APOE, MTHFR and PON1 genes in 56 stroke and 36 carotid stenosis patients, and in 124 control subjects by PCR-restriction fragment length polymorphism analysis. In the stroke group a significantly different MTHFR genotype distribution (p=0.004, odds ratio for T/T of 17.571), but no significant difference in APOE and PON1 allele and genotype distribution compared to the control was found. The carotid stenosis group exhibited a significantly different APOE allele and genotype distribution (p=0.023, odds ratio APOEepsilon3epsilon4 of 4.24), but no significant difference in the MTHFR and PON1 allele and genotype distribution from the control group. The preliminary results obtained in this study revealed an association of the MTHFR and APOE gene polymorphism with cerebrovascular disease, suggesting a significant risk for stroke in subjects who are homozygous for the T allele and for carotid stenosis in subjects having APOEepsilon3epsilon4 genotype. Additional studies in larger patient groups are needed to confirm these observations.

Adult↗
PubMed2001

Vertebral artery hypoplasia--sex-specific frequencies in 36 parent-offspring pairs.

The major interest in vertebral artery (VA) hypoplasia comes from its possible connection to migraines with aura as well as from the fact that it is one of the risk factors for a stroke. Therefore, the aim of this preliminary study was to investigate the mode of inheritance of VA hypoplasia. Initially, color Doppler of VA was performed in 64 first- and second-degree relatives of 33 probands, and the presence of VA hypoplasia was confirmed according to the already established criteria. Since a higher prevalence of VA hypoplasia (15.6%) in probands'relatives in comparison with 2.34% in the general population of Croatia was indicative of a strong familial predisposition for this condition, an analysis of family data by means of Pearson's chi-square statistics has been performed. In this analysis, the observed sex-specific frequencies of 36 parent-offspring pairs composed only of affected parent and his/her (affected or non-affected) offspring are compared to the frequencies as expected under eight proposed models. For both--autosomal and X-linked monogenetic inheritance--four hypotheses have been chosen, assuming that the individuals having the affected allele (in combination with a healthy one) have 100%, 50%, 40% and 0% chances of developing VA hypoplasia. Out of eight tested models only two--completely dominant and completely recessive X-linked models--were rejected. But, from the six non-rejected models, goodness-of-fit statistics showed that the hypothesis of X-linked inheritance of VA hypoplasia with the "healthy" allele being stronger (60% effect on phenotype)--almost perfectly fit the data (chi2 = 2.0023; df = 7; p = 0.9597). Further research encompassing a more enlarged family sample is needed to confirm the present findings.

Female↗
PubMed1999

Color Doppler flow imaging (CDFI) of the vertebral arteries--the normal appearance, normal values and the proposal for the standards.

In order to assess mean diameters and blood flow velocities (BFV), Color Doppler Flow Imaging (CDFI) of vertebral arteries (VA) was performed. Five hundred and ninety six persons without carotid disease or symptoms related to vertebrobasilar system were analyzed by CDFI of VA. Mean right VA diameter was 3.37 +/- 0.6 mm and left 3.55 +/- 0.61 mm. Women had thinner VA (p < 0.05). Left VA was wider (p < 0.05). Mean right BFV was 48.31 +/- 14.09 cm/s and left 48.93 +/- 13.94 cm/s. Females had higher BFV (p < 0.05). BFV didn't very with age (p > 0.05). The VA hypoplasia was present in 2.34%, asymmetry in 15% (left VA dominant in 64%). Visualisation of V1 and V2 segment was possible in 100% and of the origin in 81.7% on the right, and 80.7% on the left side. CDFI is a reliable method for evaluation of VA. Left VA was wider. Women had thinner VA. Hypoplasia was present in 2.34% and asymmetry in 15%.

Adolescent↗
PubMed1998

Role of vertebral artery hypoplasia in migraine.

The role of cerebral hypoperfusion in the posterior circulation has not been clearly established in migraine. The purpose of this study was to determine the role of vertebral artery (VA) hypoplasia in the pathogenesis of migraine. We studied the extracranial part of VA in 59 migraine patients (17 with and 42 without aura) using color Doppler. In migraine with aura, 29% of patients had hypoplastic VA, and in migraine without aura 7%. In migraine with aura, mean diameter of the right VA was 2.7+/-0.7 mm, and of the left 3.3+/-0.7 mm; in migraine without aura mean diameter was 3.1+/-0.5 mm on the right, and 3.3+/-0.6 on the left. In migraine with aura, mean systolic blood flow velocity was 55+/-16 cm/s on the right, 60+/-17 cm/s on the left, in migraine without aura 57+/-18 cm/s on the right, 57+/-18 cm/s on the left. We observed higher frequency of hypoplastic VA in migraine with aura, suggesting that hypoplasia of VA may be an additional factor which can lead to hypoperfusion in the posterior circulation during the aura phase.

Adult↗
PubMed1989

[Closed injuries of the diaphragm in autopsy material].

Out of 207 cases died of trauma, diaphragmatic rupture takes part in 18 (8.7%). The authors tested how often closed diaphragmatic rupture takes part with correlation of neighboring anatomic injury. Because of these rare incidence, a surgeon with injury of the next organs to the diaphragm needs always to think of it's rupture.

Diaphragm↗
PubMed1989

[Morphologic report and clinical evaluation of findings in a case of complete transposition of the great vessels of the heart and tubular hypoplasia of part of the aortic arch].

We present a case of the coexistence transposition of the great vessels, atrial and ventricular septal defects, and extreme tubular hypoplasia of the aortic arch between the left common carotid and left subclavian arteries. Beside the thorough morphological description of that uncommon combined heart malformation, evaluation of clinical analysis is performed and compared with theoretically reconstructed chemodynamismus during patient's life.

Aorta, Thoracic↗
PubMed1989

[Chronic cystitis and urinary stress incontinence in women].

Out of 534 inquired and examined women 151 (28.2%) of them had urinary stress incontinence and 383 (71.7%) women were continent. Of 151 incontinent women 75 (49.6%) of them repeatedly developed the inflammation of the urinary bladder and of 383 continent women data on chronic cystitis were registered in 74 (19.3%). These data pointed to the fact that the previous repeated inflammation of the urinary bladder and then the appearance of urinary stress incontinence could be regarded as one of etiologic factors in the occurrence of urinary stress incontinence.

Adolescent↗