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V Virsu

Publications and source records attributed to V Virsu.

At least 37 records · Page 2Linked to original sources
PubMed1983

Cell responses in dorsal layers of macaque lateral geniculate nucleus as a function of intensity and wavelength.

We studied the relationship between light intensity and cell response to various wavelengths and wavelength combinations in the dorsal, parvocellular layers of the macaque lateral geniculate nucleus. When response is plotted as a function of the logarithm of stimulus intensity, the slope and shape of curves depends on wavelength. For wavelengths near the crossover point between excitatory and suppressive responses, nonmonotonic curves are common. Consequently, the form of spectral-response functions depends on stimulus intensity. Responses to combined stimuli made up of wavelengths close together near one spectral extreme are approximately additive. If one wavelength is near the crossover point, responses are nonadditive so that a midspectral wavelength, only producing a weak excitatory response, is able to occlude more vigorous responses to wavelengths near the spectral ends. Responses of parvocellular layer cells are consistent with their being a result of linear interaction of opponent cone mechanisms, the response of each of which follows a modified hyperbolic tangent function (22). Responses to all wavelength combinations, even those showing strikingly nonadditive effects, could be predicted from the additive opponent model described above.

Animals↗
PubMed1983

Light adaptation in cells of macaque lateral geniculate nucleus and its relation to human light adaptation.

Responses of macaque lateral geniculate nucleus (LGN) cells to stimuli of different incremental intensities and wavelength compositions were studied at different levels of light adaptation from scotopic to low photopic levels. Stimuli were large in comparison with receptive-field size. Human increment thresholds were measured for comparison. The strength of responses grew in many cells from threshold up to a saturation level as a logarithmic function of incremental intensity. More complex intensity-response functions were also obtained, particularly from parvocellular layer (PCL) cells, but the shape and slope of the intensity-response function changed as a function of adaptation level only with chromatic backgrounds. As a function of adaptation level, the intensity-response functions shifted along the logarithmic abscissa but not sufficiently for a complete contrast constancy. Thus responses to any constant contrast became smaller when adaptation level decreased. The change from cone to rod responses, when possible, took place without noticeable change in shape of intensity-response functions, and much of the adaptive shift of the functions could be attributed to the change-over between rods and cones. Differences between different cells in light adaptation and dark-adapted sensitivity were large, mostly because of variation in the strength of rod input. The strongest excitatory rod inputs were found in PCL cells activated by short-wavelength light, so that the highest sensitivity at low levels of illumination occurred in blue- and blue-green-sensitive cells. The lowest increment thresholds based on cones matched the thresholds of macaque cone late receptor potentials recorded by Boynton and Whitten (3). They were also similar to human cone thresholds measured psychophysically but only for small stimulus sizes that may approximate the size of the receptive-field centers. Human sensitivity was much higher when measured with large stimulus sizes, indicating integration at post-geniculate neural levels. Light adaptation, as evaluated with respect to contrast constancy and Weber law behavior, was similarly incomplete in monkey single cells and human perception. A few cat LGN cells were studied in a control experiment; results agreed with previous findings. The light adaptation of cat cels was more complete and sensitivity higher than those observed under comparable conditions in macaque single cells and human. The maintained activity level of cells was little affected by the intensity of steady backgrounds. Thus, the steady-state hyper-polarisation of receptors was not transmitted to LGN cells.

Adaptation, Ocular↗
PubMed1982

Temporal contrast sensitivity and cortical magnification.

We measured temporal and spatial contrast sensitivity functions of foveal and peripheral photopic vision at various locations in the nasal visual field. Sensitivity decreased monotonically with increasing eccentricity when it was measured by using the same test gratings at different eccentricities. When the gratings were normalized in area, spatial frequency, and translation velocity by means of the cortical magnification factor M so that the calculated cortical representations of the gratings became equivalent at different eccentricities, the temporal contrast sensitivity functions became similar at all eccentricities. The normalization was effective under all experimental conditions that included various kinds of temporal modulation from 0 to 25 Hz (movement, counterphase flicker and on-off flicker) and different threshold tasks (detection, orientation discrimination, and discrimination of movement direction), independently of the subjective appearances of the gratings at threshold. We conclude that central and peripheral vision are qualitatively similar in spatiotemporal visual performance. The quantitative differences observed without normalization seem to be caused by the spatial sampling properties of retinal ganglion cells that are directly related to the values of M used in the normalization.

Humans↗
PubMed1982

Resolution of gratings oriented along and across meridians in peripheral vision.

Grating resolution was measured at various locations of the visual field for four grating orientations. As an instance of the oblique effect, vertical and horizontal gratings produced the highest resolution values in the central area. At eccentricities larger than about 20 deg, the oblique effect was replaced by a meridional resolution effect, in which resolution was systematically best for meridionally oriented grating bars and worst for grating bars perpendicular to the visual-field meridians. The origin of the effect seems to be neural because it was not caused by peripheral refractive errors or optical distortion of the peripheral retinal image.

Humans↗
PubMed1979

Visual resolution, contrast sensitivity, and the cortical magnification factor.

This study shows that photopic contrast sensitivity and resolution can be predicted by means of simple functions derived by using the cortical magnification factor M as a scale factor of mapping from the visual field into the striate cortex. We measured the minimum contrast required for discriminating the direction of movement or orientation of sinusoidal gratings, or for detecting them in central and peripheral vision. No qualitative differences were found between central and peripheral vision, and almost all quantitative differences observed could be removed by means of a size compensation derived from M. The results indicated specifically that (1) visual patterns can be made equally visible if they are scaled so that their calculated cortical representations become equivalent; (2) contrast sensitivity follows the same power function of the cortical area stimulated by a grating at any eccentricity; (3) area and squared spatial frequency are reciprocally related as determinants of contrast sensitivity; and (4) acuity and resolution are directly proportional to M, and the minimum angle of resolution is directly proportional to M-1. The power law of spatial summation expressed in (2) and (3) suggests the existence of a central integrator that pools the activity of cortical neurons. This summation mechanism makes the number of potentially activated visual cells the most important determinant of visibility and contrast sensitivity. The functional homogeneity of image processing across the visual field observed here agrees with the assumed anatomical and physiological uniformity of the visual cortex.

Brain Mapping↗
PubMed1979

An estimation and application of the human cortical magnification factor.

Comparisons of the published data on the density D of receptive fields of retinal ganglion cells and on the cortical magnification factor M indicated that M2 is directly proportional to D in primates. Therefore, the human M can be estimated for the principal meridians of the visual field from the density-distribution of retinal ganglion cells and from the density of the centralmost cones. Using the previously published empirical data, we estimated the values of the human M and express the values in four simple equations that can be used for finding the value of M for any location of the visual field. The monocular values of M are not radially symmetric. These analytically expressed values of M make it possible to predict contrast sensitivity and resolution for any location of the visual field. We measured contrast sensitivity functions at 25 different locations and found that the functions could be made similar by scaling the retinal dimensions of test gratings by the inverse values of M. Visual acuity and resolution could be predicted accurately for all retinal locations by means of a single constant multiplier of the estimated M. The results indicate that the functional and structural properties of the visual system are very closely and similarly related across the whole retina. Visual acuity, e.g., bears the same optimal relation to the density of sampling executed by retinal ganglion cells at all locations of the visual fields.

Brain Mapping↗
PubMed1979

[Inhibition and space-frequency characteristics of the complex receptive fields of the cat visual cortex].

Responses of complex receptive fields of the cat straitum to moving sinusoidal grating were studied. Stimulation of the receptive field with some spatial frequencies suppresses spontaneous discharges. Responses of the receptive field corroborate previously made predictions that the spatial--frequency characteristics of the receptive field should have the main and the secondary maximums and negative areas in case the complex fields perform piece-wise Fourier--transformation of image. The changes of impulse frequency in field's response are predicted by comparing the changes of instantaneous spectrum of grating entering the field with spatial frequency characteristic of the field. The data evidence that the complex field is rather a spatial--frequency filter than a detector. Some complex fields reveal a lateral inhibitory area behind the field's nucleus in direction of stimulus movement. The complex fields with no lateral inhibitory areas seem to serve for piece Fourier--description of image, those with lateral areas--for picking out the countour between textures.

Animals↗
PubMed1978

Retinal mechanisms of visual adaptation and afterimages.

Recent results obtained from recordings of isolated photoreceptor activity and from correlations of this activity with time-dependent changes in the responses of other retinal cells in several vertebrates have made a thorough revision of former theories of visual adaptation necessary. The present paper reviews the current state of research and relates the new discoveries with psychophysical findings in an attempt to explain human light and dark adaptation from the novel starting point. The former conceptions of adaptation have to be replaced with a three-level process consisting of photochemical receptor neural and network adaptation. Several adaptive mechanisms can be discerned at each level. Depending on adaptation conditions, any level of the three can play a dominating role and can also produce afterimages that display the behaviour of the mechanisms working at each level. The total achievement of visual adaptation is an optimized end product of the actions of all the various mechanisms.

Adaptation, Ocular↗
PubMed1977

Dark adaptation and receptive field organisation of cells in the cat lateral geniculate nucleus.

The receptive fields of LGN cells were investigated with stationary light and dark spot and annulus stimuli. Stimulus size and background intensity were varied while stimulus/background contrast was kept constant. The speed of dark adaptation vaired considerably from cell to cell. Dark adaptation made responses more sustained in all neurones and eliminated the oscillatory on-responses evoked under some conditions in the light-adapted cells. Dark adaptation led also to a disappearance of early phasic inhibition in on-responses, and increased response rise time and latency. The power of surround responses to inhibit centre responses decreased slightly at low levels of light adaptation in LGN cells but much less than in retinal ganglion cells. Some other traces of changing retinal surround effects also appeared inthe LGN on dark adaptation. For example, the functional size of receptive fields increased at low levels of illuminance as has been observed in retinal ganglion cells and the receptive fields as estimated from response peaks were larger than those estimated from sustained components.

Animals↗
PubMed1977

Responses of cells in the cat lateral geniculate nucleus to moving stimuli at various levels of light and dark adaptation.

The responses of neurones in laminae A and A1 of the cat lateral geniculate nucleus to moving stimuli were investigated at different background luminances. Moving bright slits, dark bars and edges were employed; the contrast of stimuli against the background was held constant. Background intensities varied from 10(-3) to 10(2) td. Responses as stimuli passed across the centres of LGN receptive fields became stronger with increasing levels of light adaptation up to 10(-1)-10(1) td and then remained constant. Responses as stimuli passed through surround regions altered qualitatively with adaptation level, generally increasing in strength and complexity with background luminance. As a bright slit for on-centre cells or dark bar for off-centre cells left the surround, in almost all units a strong secondary peak could be elicited by an appropriate selection of the adaptation conditions. Many features of the responses to moving stimuli could not be predicted from the responses to stationary stimuli under different adaptation conditions described in the previous paper.

Animals↗