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Biomedical subjects

V V Tsurko

Publications and source records attributed to V V Tsurko.

At least 19 recordsLinked to original sources
PubMed2001

[Comparative evaluation of tissue microcirculation in patients with aseptic necrosis of the femur head in rheumatoid arthritis and systemic lupus erythematosus].

AIM: Comparative investigation of tissue microcirculation above hip joints affected with verified aceptic necrosis of the heads of the femur (ANHF) in patients with rheumatoid arthritis (RA) and SLE. MATERIAL AND METHODS: The microcirculation was compared in 44 RA and 22 SLE patients. Capillary blood flow above the necrotic heads of the femur was studied by 133-Xe clearance from the intratissue depot. Laser doppleroflowmetry examined basal blood flow and factors of its regulation. RESULTS: Effective skin blood flow decreased both in RA and SLE patients at ANHF stage I, remained low at stage II, went up a little at stage III. At stage IV the flow continued to rise in RA patients but fell sharply in SLE. Laser dopplerflowmetry with functional tests reflects ANHF evolution both in RA and SLE. CONCLUSION: Changes in capillary blood flow in SLE above the necrotic heads of the femur are more severe and account for more extensive destruction in the heads of the femur than in patients with RA.

Adult↗
PubMed2000

[Osteoarthrosis].

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Analgesics↗
PubMed1999

[Assessment of tissue microcirculation in patients with aseptic necrosis of femur heads in systemic lupus erythematosus (SLE)].

AIM: To study microcirculation in the tissues above the hip joints with and without aceptic necrosis of the femur head for diagnosis of necrosis stages. MATERIALS AND METHODS: 22 SLE patients were examined for blood flow above the region of affected and intact (control) hip joints using clearance of Xe-133 from the intratissue deposit. Basal circulation and factors of its regulation were investigated with laser dopplerflowmetry. RESULTS: Effective skin blood flow above the hip joints with necrosis stage I significantly differed from that of the control. Basal skin blood flow above the hip joints in suspected stage I of aceptic necrosis differed significantly from the control and that in stage II osteonecrosis. CONCLUSION: The study of tissue microcirculation above the hip joints in SLE patients with aceptic necrosis of the femur heads allows making diagnosis both at early and late stage of osteonecrosis.

Blood Flow Velocity↗
PubMed1997

[A comparative evaluation of local therapy methods in treating osteoarthrosis deformans].

71 patients with knee joint osteoarthritis deformans in exacerbation with weak exudative component have received outpatient treatment: intrajoint injections of kenalog with novocaine, jet intra- and periarticular injections of the above drugs, magnetolaser therapy (groups 1, 2 and 3, respectively). The response was obtained in 85, 90 and 75%, respectively. Neither toxicity nor complications were recorded. The above methods are recommended for use in outpatient departments and clinics.

Aged↗
PubMed1995

[Corticosteroid therapy and aseptic bone necrosis in patients with rheumatoid arthritis].

Two groups of RA patients were compared: 102 patients with osteonecrosis of the head of the femur (group 1) and 50 patients free of it (group 2). Group 1 patients had bilateral lesion of the hip joints (28% of cases), unilateral osteonecrosis of knee joint in 14.5% and bilateral in 2.9% of the patients. Unilateral humeral osteonecrosis occurred in 17.6%, bilateral in 4.9% of patients. Extra-articular manifestations of RA (lymphadenopathy, renal lesions and Cushing's syndrome) were diagnosed more frequently in group 1. Progression of osteonecrosis is related to a mean maximal day dose of prednisolone in the first month of therapy.

Adrenal Cortex Hormones↗
PubMed1994

[An assessment of tissue microcirculation in patients with aseptic femur head necrosis in rheumatoid arthritis].

Tissue microcirculation above the area of hip joint projection was investigated by 133Xe clearance from the tissue depot and laser-Doppler flowmetry in 38 rheumatoid arthritis patients with complicating aseptic necrosis in 69 heads of the femur. The methods proved reliable in diagnosis of the above microcirculatory disorders and in staging osteonecrosis. Combined use of the procedures was found effective in detection of early circulatory disorders and early aseptic necrosis.

Arthritis, Rheumatoid↗
PubMed1994

[The mechanism of the action of laser therapy in rheumatoid arthritis].

48 patients with rheumatoid arthritis (RA) were exposed to He-Ne laser radiation. Due to the course of the above laser therapy the patients displayed reduced levels of E and F2 alpha prostaglandins, a trend to a decrease of lipid peroxidation products, glycosaminoglycans and collagen-peptidase activity. This evidences for suppression of the inflammation and destruction in the connective tissue. Catalase activity in red cells enhanced. The authors point to high efficacy of low-intensity He-Ne laser in moderate rheumatoid inflammation.

Arthritis, Rheumatoid↗
PubMed1988

[Clinico-instrumental methods of diagnosing aseptic femur head necrosis in patients with systemic lupus erythematosus].

Clinical, x-ray and scintigraphic investigations were performed in 34 patients with systemic lupus erythematosus (SLE): 24 patients with SLE complicated by osteonecrosis of the head of the femur (the 1st group) and 10 patients with SLE without clinicoroentgenological signs of aseptic necrosis (the 2nd group). Analysis of the results of scintigraphic investigation showed that the coefficient of radionuclide absorption in the SLE patients with suspected osteonecrosis (stage I) as compared to the controls and patients with stage II osteonecrosis of the head of the femur turned out to be significantly discernible (p less than 0.001). Thus, an early stage of osteonecrosis of the head of the femur can be reliably diagnosed by scintigraphy. Quantitative scintigraphy can be effectively used for dynamic observation and objectification of applied therapy.

Femur Head↗
PubMed1987

[Herpes zoster--an unusual complication of gold therapy].

The authors observed the development of herpes zoster in 2 rheumatoid arthritic patients against a background of chrysanol therapy. Such a complication should be regarded as an indication for aurum drug cancellation. The study provided an opportunity for specifying some aspects in the mechanism of action and indicated a possible immunodepressive effect.

Arthritis, Rheumatoid↗
PubMed1987

[Rehabilitation of patients with gout during outpatient follow-up].

The authors presented the results of a 5-year follow-up of 50 gout patients who had been regularly (no less than 3-4 times a year) examined in outpatient clinics. Dispensary examinations of the patients resulted in a decrease in the level of uric acid and in the number of exacerbations of gouty arthritis, the reduction of the sizes of tophi or their disappearance. Regular examination and ultrasonic investigation made it possible to prevent in some cases attacks of urolithiasis, and to reduce 4-fold a disability time-period and to preserve working capacity in 96% of the patients. The study showed that in most of the patients with essential hypertension and coronary heart disease arterial pressure got stable and the number of angina attacks was on a decrease. The data obtained indicated a high efficacy and appropriateness of combined rehabilitation activities in gout patients.

Adult↗
PubMed1987

[Clinico-roentgenological and scintigraphic parallels in aseptic femur head necrosis in patients with rheumatoid arthritis].

A clinicoroentgenological study was performed in 35 rheumatoid arthritic patients (of them 24 with aseptic necrosis of the femoral heads and 11 without clinicoroentgenological signs of the hip joint involvement). Aseptic necrosis, stage II, was roentgenologically defined in 12 femoral heads, stage III in 23. An analysis of the results of the scintigraphic study showed that the RP absorption ratio in the rheumatoid arthritic patients with aseptic necrosis was significantly higher than that in the control group. Significant scintigraphic differences between stage II and III of aseptic necrosis were also revealed (the ratio of 99mTc absorption was 2.79 +/- 0.156 and 4.08 +/- 0.22, respectively).

Arthritis, Rheumatoid↗
PubMed1986

[Echodiagnosis of the kidney lesion in gout].

An echographic study of the kidneys was performed in 24 men with proved gout aged 40 to 50 and a disease duration of 10-20 yrs. On the basis of case history data urolithiasis was noted in 4 patients, whereas by echodiagnosis it was found in 12. Cysts were detected in 6 patients with gout complicated by urolithiasis and in 1 patient without it. Echoroentgenography was shown to be a highly informative method in the diagnosis of urolithiasis and cystic regeneration of the kidneys opening up prospects for earlier treatment of complications in gout.

Adult↗
PubMed1986

[Evolution of seronegative arthritis].

The paper is concerned with the results of a follow up of 67 patients with seronegative arthritis. The average duration of observation was 7.6 yrs. Diagnoses in 4 patients were established on a repeated clinicolaboratory and x-ray study: ankylosing spondylitis, Reiter's syndrome, Yersinia arthritis and gonorrheal arthritis. A picture of seropositive rheumatoid arthritis was noted in 16 patients (24%). In 47 patients arthritis remained seronegative. Of them in 30 patients a course of disease did not differ from that of seropositive rheumatoid arthritis. Considerable progression of disease was noted at the acute onset of disease with multiple involvement of the joints and a high inflammatory and immunological activity of a process. A morphological investigation of the synovial bioptates in 20 patients did not reveal a classical picture of rheumatoid synovitis even in a prolonged course of seronegative rheumatoid arthritis. The authors defined two variants of morphological changes in the synovial tissue in this group corresponding to a benign and progressive course of seronegative RA.

Adult↗
PubMed1984

[Gout].

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Arthritis↗
PubMed1983

[Effect of monochromatic red helium-neon laser on the morphology of zymosan arthritis in rats].

Histological and electron microscopy findings suggesting the effect of monochromatic coherent polarized red light on zymosan arthritis in rats are presented. The data obtained have confirmed that treatment of inflamed joints with laser rays exerts an evident therapeutic effect which is determined by activated function of macrophages and fibroblasts of the synovial membrane, resulting in a more rapid change of inflammation phases. Analysis of the cases where the rats were treated with ordinary red light has revealed no essential differences in the joints of the control and irradiated groups.

Animals↗