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Biomedical subjects

V V Tomson

Publications and source records attributed to V V Tomson.

30 records · Page 2Linked to original sources
PubMed1987

[Characteristics of the morphofunctional status of the tissue in the rat cerebral cortex in experimental renal arterial hypertension].

Activity of some enzymes in the cerebral cortex of rats with experimentally induced renal arterial hypertension (AH) was studied histochemically. Histologic data provide the evidence for the disturbances in water-salt metabolism in AH. Morphometric study revealed an increase in the specific volume of smaller microvessels and moderate decrease in the specific volume of bigger microvessels. Vascular markers show different time course of activity changes in AH: the activity of alkaline phosphatase increases, while that of alpha-glycerophosphate dehydrogenase remains unchanged. The development of AH is accompanied by the increase in succinic dehydrogenase activity and the decrease in the activity of lactate dehydrogenase in neurons. The changes in the neuron-capillary relationship arising in AH can be one of the possible pathogenetic factors in the pathologic process progression.

Alkaline Phosphatase↗
PubMed1977

[Histoenzymologic characteristics of the human fetal pituitary under conditions of maternal hyperestrogenism].

The development of the fetus adenohypophysis analyzed under the conditions of high doses of sinestrol, administered to mothers, revealed certain morphofunctional characteristics in the group studied in comparison with the control. In normal pregnancy, a gradual increase in protein content and in nucleic acids activity are noted, as well as an increase in the enzymes in protein synthesis and transport within the cell. Under maternal hyperestrogenity, however, in the adenohypophyseal cells of 7--14 week-old fetuses, a decrease in the content of hormonal protein-precursors, nucleic acid activity, inhibition of synthesis and trnsport processes are observed.

Acid Phosphatase↗
PubMed1976

[Cytophotometric analysis of proteins in human embryo hypophyseal cells in normal and pathologic pregnancies].

As it is known, formation of the adenohypophysis in the human fetus takes place at early stages of ontogenesis. The objective of the present work was to find out whether the adenohypophysis, already at these early stages of development, was capable to response to changes in the environment, in this case to those in the mother's organism. Two groups of the human adenohypophyses obtained as a result of artificial abortion were studied: 1) from fetuses which developed under normal pregnancy; 2) from fetuses which developed under pathological pregnancy (toxemia in the first half of pregnancy). The method of quantitative cytospectrophotometric analysis of simple and conjugated proteins of a various nature were used. The data obtained indicated to early appearance of simple and conjugated proteins in the cells of the anterior lobe of the hypophysis of the human fetus and to their definite dynamics depending upon the course of pregnancy. It was established that at early stages of ontogenesis the adenohypophysis of the human fetus produces a certain reaction to changes in the environment, in particular, to changes occurring in the mother's organism.

Female↗
PubMedDate not supplied

[Analysis of morphological changes in the spinal cord and ganglia of dogs after epidural administration of prosidol, clopheline and prosidol-clopheline combination].

Experiments were carried out on 22 mongrel dogs (12-20 kg). Group 1 consisted of 5 dogs to which prosidol in a dose of 0.65 mg/kg was injected epidurally; group 2, 5 dogs, clofelin (6.5 micrograms/kg) epidurally; group 3, 5 dogs, prosidol (0.65 mg/kg) + clofelin (6.5 micrograms/kg) epidurally. Control groups were as follows: 1) 5 intact dogs; 2) 2 dogs epidurally injected with 0.9% normal saline. Analysis of the spinal cord and ganglia in control groups showed no dystrophic changes in neurons. After epidural injections of prosidol, clofelin, or both only solitary cells with degenerative changes were detected or none at all. Nissle granules were evenly distributed in the cytoplasm of anterior and posterior spinal horn neurons in all control and experimental animals. The majority of ganglious cells in control and experiment had the nucleus and nucleolus. Hence, morphological analysis showed that epidural injection of prosidol, clofelin, and a combination of both caused no degenerative or necrobiotic changes in the anterior and posterior spinal horn neurons and in ganglious cells of spinal ganglia.

Analgesics↗
PubMedDate not supplied

[Enzymatic activity in spinal cord neurons after epidural administration of clopheline in dogs].

Time course of the major enzymes (SDH, LDH, GPDHcyt, GPDHmit, AP) and protein synthesis (DNA, RNA) in spinal neurons and spinal ganglia after epidural injection of clofelin were studied in an acute experiment on dogs. No physiological or neurological disorders or depriming effect of clofelin on the major enzymatic systems and protein synthesis in nervous tissue of dogs were detected. Increased activity of AP in the spinal white and gray matter is worthy of note, which indicates intensification of active transport in spinal capillary epithelium after epidural injection of clofelin.

Alkaline Phosphatase↗
PubMedDate not supplied

[Morphological and histochemical changes in the spinal cord after epidural administration of prosidol in dogs].

Morphological, histochemical, and histoenzymatic changes in the nervous tissue of the spine and spinal ganglia after epidural injection of narcotic analgetic prosidol were studied in acute experiment on 12 mongrel dogs. No negative effect of prosidol on neuronal structure and nervous tissue microcirculatory bed were observed in experimental vs. control animals. The type of changes and their direction in various compartments of the nervous system (spine and spinal ganglia) were similar in control and experimental animals.

Acid Phosphatase↗
PubMedDate not supplied

[Evaluation of the local neurotoxicity of lidocaine following epidural administration].

The morphological and histoenzymological changes in spinal neuron and in the spinal ganglia of outbred dogs were analyzed in the epidural administration of 2% solution of lydocaine. The results showed a lack of pathological or structural-and-metabolic changes in the nervous tissue. The morpho-functional reshaping occurring in the spinal cord cells and in the spinal ganglia was in line with that when the 0.9% solution of sodium chloride was in use. The registered changes ranging within the physiological deviations' limits witnessed to a functional reaction of the studied nervous-tissue structures to epidural drugs' injections.

Anesthetics, Local↗
PubMedDate not supplied

[General pathological aspects of the hair cells damage in spiral organ].

The information concerning general pathological changes in hair cells of the spiral organ is reviewed. The conditions for the onset, morphological picture of dystrophy, necrosis, apoptosis typical for hair cells in respect to structural and functional features of the sensory epithelium of the spiral organ are outlined. Nonspecific morphological changes of the spiral organ neuroepithelium after the action of damaging agents of different origin (such ototoxic drugs as aminoglycoside antibiotics and others, intensive acoustic impacts, ageing of the acoustic analyzer) are emphasized.

Animals↗
PubMedDate not supplied

Functional morphology of the bronchovascular barrier of the human lungs during various age periods.

Cellular components of the bronchovascular barrier have been studied in human lungs obtained after death of some patients with acute and chronic lung inflammatory diseases, hypertonic disease, atherosclerosis and chronic glomerulonephritis. Certain oxidative-reductive and hydrolytic enzymes, including NAD-, NADP- diaphorases, lactic dehydrogenase, acid and alkaline monophosphoesterase, ATP-ase, adenylate cyclase and nonspecific esterase were evaluated quantitatively after the histochemical processing of the specimens for the above reactions. Correlation analysis was performed for the bronchial epithelium, endotheliocytes, lymphocytes, plasma and mast cells, as well as macrophages and polymorphonuclear leucocytes. The results showed that there was a significant shift in some of the measured enzymic activities. Moreover, the correlations between different quantitative data were noted and these correlations changed with age. The increase in "rigidity" of the correlations in the elements of the bronchovascular barrier has been demonstrated during the process of ageing.

Adult↗