In chronic experiments on dogs the effect of introduction of a non-buffered acid gastric juice into the duodenum or/and of drawing outside the bile via a fistula in the common bile duct on theproduction of hydrochloric acid in innervated ventricles (pouches) was studied. The induced pH shifts in the duodenum were checked every 15 minutes in the duodenal chyme samples. In tests involving meat feeding the reduced pH of the duodenal contents acted not only as an inhibitor of the gastric secretion, but much more as its stimulator. Infusion of the juice into the duodenum, or/and elimination of the bile tended to drastically reduce the inhibitory effect of the fat on the acid-formation in the stomach, this being due to inactivation of the pancreated lipase with HCl and to a defective micellar stage of the intraintestinal transformation of fat. This gives ground to assume that the entrance of acid non-buffered gastric juice into the intestine during transtubal feeding of patients with peptic ulcer is counter-productive in this method of treatment. The application of hyposecretory agents concurrent with the tubal feeding is warranted.

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PubMedDate not supplied

[Secretion of proteolytic enzymes following administration of nutrients into the duodenum and jejunum].

Infusion of nutrient fluids into the small intestine of dogs provoked the appearance of Pavlov's pouch juice displaying different proteolytic activity. The quantity of the juice was smaller with drop than with jet infusion. The total secretion of enzymes was more abundant in case of drip intraduodenal infusions of a milk and cream mixture, milk, aminocrovine as compared with its average level following introduction of 10 and 20 per cent solutions of sugar, lipomaize, emulsions prepared of dry dairy products and vegetable oil. The infusions into the duodenum and jejunum was followed by secretion of substantial amounts of the pancreatic juice displaying high activity of trypsin, close to that appearing in response to feeding on meat. The concentration of proteases in the intestinal chyme proved then sufficiently high.

Animals↗