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Biomedical subjects

V V Serov

Publications and source records attributed to V V Serov.

At least 19 recordsLinked to original sources
PubMed1992

[Sclerosis and carcinogenesis].

Morphological analysis of the sclerotic changes in peripheral lung carcinoma (PLC) and nephrosclerosis in renal-cell carcinoma (RCC) established a promoting role of sclerosis in carcinoma development. The pneumosclerosis role as a background process in the PLC development is proved by the following facts: high proportion (83%) of the carcinoma in the scar among PLC; identity of the scar collagen composition in PLC and that in metatuberculosis and metapneumonic pneumosclerosis foci; detection of metatuberculosis foci in 75% of PLC; the presence of the precancerous changes in the epithelium entrapped in the pneumosclerotic foci, not only with signs of morphological atypia, but with the disturbance of nuclear DNA and cellular oncogene expression as well. The association of RCC with nephrosclerosis is shown by a high proportion (82.7%) of the RCC development against the background of nephrosclerosis; the dependence of the so-called cortical adenoma development on the degree of nephrosclerosis; epithelial proliferation in the nephrosclerotic foci with the appearance of undifferentiated cells with the altered DNA content and the expression of cytokeratins and vimentine. Carcinoma morphogenesis against the background of sclerosis may be described as follows: development of sclerosis (focal and/or diffuse), the appearance of the focal epithelial hyperplasia in the scar, dysplasia or adenoma and finally carcinoma.

Adenoma↗
PubMed1992

[The prognosis of the accelerated progression of chronic glomerulonephritis].

Based on the data of the 20-year follow-up of 146 patients suffering from intracapillary chronic glomerulonephritis (CGN) verified with the aid of nephrobiopsy, the conclusion was made about the necessity of distinguishing rapid-progressing CGN. In such pattern of CGN, chronic renal failure may occur for up to 5 years since the disease onset. A significant relationship was established between the incidence of rapid-progressing CGN and the morphological and clinical types as well as tubulointerstitial alterations. The clinical types included the active and inactive nephritic, nephrotic and nephrotic-hypertonic types. A regressive analysis made according to the Cox method permitted one to establish that the clinical type of CGN is the most reliable factor of predicting rapid-progressing disease.

Age Factors↗
PubMed1992

[Liver cirrhosis and lymphoproliferative diseases].

Seven patients suffering from liver cirrhosis combined with lymphoproliferative diseases: chronic lymphoid leukemia (n = 4), lymphosarcoma (n = 3) were placed under observation. Viral etiology of liver cirrhosis was established in 4 patients (HBV markers were revealed in the serum in 2 and in liver tissue in 1) and was assumed in 3 patients (the lack in the anamnesis of other hepatotropic factors; multilobular form of liver cirrhosis). In 5 patients, the lymphoproliferative disease was diagnosed 2-30 years after the appearance of the symptoms of chronic diffuse liver disease. In 2 patients liver cirrhosis and hemoblastosis showed up simultaneously. The role of hepatitis viruses, HBV in particular, in the onset of lymphoproliferative diseases is under discussion.

Adult↗
PubMed1992

[Autoimmunization and autoimmune diseases].

Autoimmunization is understood as a type of immune reactions to the unchanged autoantigens only. Autoimmune processes can be subdivided into the physiological ("sanitary" and regulatory) and pathological ones. Physiological processes are of importance in supporting natural immunological tolerance while pathological processes develop on the basis of the physiological ones in presence of various defects of suppressive mechanisms of the immune system. Pathological processes are the basis of the autoimmune diseases and diseases with secondary autoimmune disturbances. The distinction between organo-specific and organo-nonspecific autoimmune diseases can be taken as their preliminary tentative classification.

Antigen-Antibody Reactions↗
PubMed1992

[Clinical pathology due to hepatitis B virus].

All information accumulated during last 10 years allows the view on the alterations produced by hepatitis B virus as ubiquitous. Extrahepatic pathology in hepatitis B is associated with the immunocomplex and immunocellular mechanisms but more frequently with their combination. Wide spread of hepatitis B virus infection and high level of morbidity, persistence of the virus in the organism necessitate further study of clinical pathology associated with this virus.

Antigen-Antibody Complex↗
PubMed1991

[Inflammation, adaptive regeneration and dysregeneration (intercellular interaction analysis)].

Inflammation, regeneration and fibrosis are inseparable components of the adaptive tissue response to damage. Systemic analysis indicates that this reaction is brought about due to the cooperative interaction of the connective tissue and blood cells (neutrophils, labrocytes, thrombocytes, macrophages, lymphocytes, fibroblasts) between each other, with intercellular matrix (collagen, fibronectin, proteoglycans) and organ parenchyma on the basis of feedback mechanisms. The role of the "cell orchestra conductor" changes at different stage of reaction; macrophage-fibroblast interaction is the most important in the cooperation between inflammation and regeneration. The breakdown of the homeostatic autoregulatory mechanisms (particularly those of intercellular and intertissue interaction) results in the disturbance of standard reactions, disintegration of inflammation and regeneration, chronicity of inflammatory reactions, incomplete regeneration, progressing sclerosis, formation of deficient granulation and fibrous tissue, tendency to the secondary destruction. The process loses the adaptive character and the notion of "dysregeneration" is introduced for its characteristics.

Adaptation, Physiological↗
PubMed1991

[Autoimmunization: new facts, controversial questions and study prospects].

At present autoimmunization is viewed as a complex of immune responses to unchanged autoantigens, bearing in mind that autoimmune processes can be "physiologic" ("sanitary" and "regulatory") and pathologic, underlying autoimmune diseases and illnesses associated with secondary autoimmune disorders. The "physiologic" autoimmune processes may be an element of the regulatory mechanisms of homeostasis. The pathologic autoimmune processes develop on the basis of the physiologic ones in the presence of immune disorders in the form of varying defects of the suppressor mechanisms of the immune system. Among the mechanisms of autoimmunization, predisposing, initiating and contributory factors may be distinguished. Of paramount importance is thymic dysfunction whose character has not been completely disclosed. The alterations in the lymphoid organs and tissues (target organs) hypersensitivity reactions (with the exception of reagin ones) form the morphological substrate of autoimmune diseases. Distribution of autoimmune diseases into organ-specific and non-organ-specific can be accepted as the working classification.

Antigen-Antibody Reactions↗
PubMed1991

[Nature of cloudy swelling and granular degeneration of parenchymatous organs].

There is a basis to consider a cloudy swelling of parenchymatous organs as one of manifestations of albuminous or, more correctly, albuminous-hydropic degeneration. It has characteristic macroscopic (cloudy swelling) and microscopic ("hydropic oedema", granular degeneration) signs and various patho--and morphogenetic mechanisms. Granular degeneration may be not only an expression and synonym of albuminous-hydropic degeneration but a manifestation of functional tension, i.e. adaptation, as well. Heterogeneity of the concept "cloudy swelling" is due to the peculiarities of its pathogenesis while the heterogeneity of the concept "granular degeneration" is due to double pathologic interpretation of this phenomenon, adaptation and degeneration which are divided by the time factor only which determines the break of adaptation.

Adaptation, Physiological↗
PubMed1990

[The pathogenesis of congenital thymus hyperplasia in children with immune defects].

Complex clinical and morphological studies were conducted into conditions of the thymus as well as of the lymphatic and neuro-endocrine systems in stillbirths and children up to five years of age. Thymic hormones in blood and thymic tissue were determined, as well. CTH, in most of these cases, was found to reflect dysfunction of the hypothalamic-hypophyseal system which eventually resulted in development of polyglandular endocrinopathy and congenital immune deficiency, primarily in the T-system. CTH has proved quite often to be associated with congenital malformations.

Child, Preschool↗
PubMed1990

[Clinical and morphologic factors for assessment of risk of progression of chronic glomerulonephritis].

In 182 patients suffering from bioptical-proved and functional adapted chronic glomerulonephritis the relation between clinical course, morphological type and progression of disease has been evaluated. The presented results show a significant relation between the clinical course of chronic glomerulonephritis and the progression trend of this disease. The early finding of sclerotic changes may follow a benign course of the disease.

Adult↗
PubMed1990

[Mesangioproliferative glomerulonephritis with IgM deposits as an independent form of nephritis].

On the basis of 32 patients examination clinicomorphological characteristics of the mesangioproliferative glomerulonephritis (MPGN) with IgM deposits are given. The conclusion is drawn that MPGN is a distinct unity in the group of primary GN as well as in the group of IgM--nephropathy. The main pathogenetic component of the development of MPGN with IgM deposits is the fixation of IgM, especially in combination with C3. Moderate hypertrophy and hyperplasia of mesangiocytes, mesamgium enlargement and secondary changes in glomeruli characterize MPGN with IgM deposits electron-microscopically and light optically. MPGN with IgM deposits is followed by nephrotic syndrome in 3/4 cases although other clinical forms of nephritis can also take place. In most cases its clinical course is protracted and benign.

Adolescent↗
PubMed1990

[Early stomach cancer: its morphology, histo- and morphogenesis].

Macroscopic, histologic and ultrastructural features of an early stomach carcinoma are presented on the basis of literature and the authors' data. Ultrastructural and immunohistochemical data confirm the concept of a common histogenesis of different histologic types of stomach carcinoma, i.e. from reserve cells. Carcinoma, most likely, develops from reserve cells of the foveolate epithelium and metaplastic epithelium of intestinal type (foci of incomplete intestinal metaplasia with sulfomucine secretion). The data are accumulating on the precancerous nature of severe epithelial dysplasia. The development of an early carcinoma from preexisting dysplasia was observed in patients after long follow-up with repeated gastric biopsies.

Carcinoma in Situ↗
PubMed1990

[Functional and morphological characteristics of a hematuric form of chronic glomerulonephritis].

Clinical evidence has been analyzed for 325 patients with chronic glomerulonephritis confirmed histologically. It was established that chronic glomerulonephritis (CG) associated with hematuria exhibits some specific characteristics: great ability for maximal osmotic concentration and partial ability for ammonium excretion in membranoproliferative CG without sclerotic lesions, maximal occurrence in membranoproliferative form of the disease; fibroplastic transformation of the glomeruli is a rare finding. CG with hematuria is worth mentioning in CG diagnosis.

Adolescent↗