Biomedical subjects
Publications and source records attributed to V V Sedov.
The irradiation of hospital linen contaminated with radioresistant microorganisms or hospital microflora with gamma radiation in a dose of 10 kGy ensures the reliable microbial decontamination of such linen. Cotton linen has been found capable of withstanding 15 irradiation cycles in a dose of 10 kGy.
Scintigraphy following intravenous administration of 0.1% solution of 11-(ortho-iodine-131-benzoylamino) undecoic acid to rabbits in experimental cholestasis has shown that the intensity of beta-oxidation of this fatty acid in the liver decreases on the 2nd day of cholestasis. Its biological half-life in the liver significantly increases, at an average, 1.75-fold. On the 3rd day this value changes almost 3 times. The extraction of the acid by the liver changes from the first day of cholestasis. Disturbance of renal function from the 2nd day of cholestasis has been also noted. At the same time no significant differences in the time course of changes in the content of 131I-rose bengal have been detected in 1 and 7 days of cholestasis up to the death of part of the animals. The data obtained indicate a possibility of employing the radionuclide method of investigation of change in the intensity of beta-oxidation of fatty acids with the help of the above compound to assess a degree of hepatocytic affection in cholestasis.
The pharmacokinetics of 99mTc and 113mIn labeled aminopolymethyl phosphonic acids was studied in experiments on animals. Noticeable osteotropism of these compounds was shown. Scans of the rabbit and rat skeleton in health and experimental pathology 1 h after i.v. administration of these compounds were obtained making it possible to reveal the affected foci.
The pharmacokinetics and metabolic features of I-radionuclide labelled derivatives of aliphatic carboxylic acid were studied in experiment. The authors show the possibilities of nuclear medicine in deriving information on the activity of fatty acid beta-oxidation in the animal liver and body using compounds with C4 = C11 aliphatic chain locus.
Modern radiopharmaceuticals are used to get information on the anatomy and function of the liquor system, i. e. they make it possible to monitor a radionuclide biological behavior in vivo by external detection. Complex compounds like diethylene triamine pentacetic acid (DTPA) labeled with 111In or 99mTc are the most common radionuclides used abroad to study the liquor system pathology. The clinicoexperimental studies on the use of the 111In-Ca-DTPA complex for radionuclide cisternography elaborated in this country, took 2 years. Experiments on animals showed that 70% of the administered amount of the radionuclide left the liquor pathways 4 h later. The administration of a clinical dose 5 times as high demonstrated the drug safety. The Soviet radiopharmaceutical was evaluated by comparing under clinical conditions 3 radionuclides: 111In-DTPA (France), 99mTc-DTPA (FRG) and 111In-Ca-DTPA (USSR). The radiological picture of radionuclide distribution by the liquor pathways did not depend on the drug. Radiological signs showed a direct correlation with a disease entity.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The extension of the Q-T interval of ECG can be accompanied by loss of consciousness and even sudden death. A unified approach is required to assess the normal duration of the Q-T interval. A table of maximum normal limits of the Q-T interval is given calculated with Bazett's formula with the coefficient K equal to 0.42. It is suggested to subdivide the extensions of the Q-T intervals according to the clinical manifestations with attacks of loss of consciousness and without them and also according to aetiology: congenital syndrome Jarvel-Lange-Nielsen and that of Romano-Ward, the acquired acute (intoxications, disorders of electrolyte balance, lesions of the central nervous system, myocardial infarction, myocarditis, medicinal reactions) and the acquired chronic (diffuse lesions of the myocardium, of the brain etc.). Personal observations of syndromes of extended Q-T intervals of different aetiology are given with attacks of ventricular tachycardia of the "torsade de pointes" type and ventricular fibrillation.
Changes in the antibioticograms after a single irradiation of dry cultures of microorganisms isolated at a pharmaceutical factory were noted in 0.5 per cent of 686 microbial strains tested. Restoration of sensitivity to one or more often several antibiotics was found in the microbes with the changed antibioticograms. After a three-fold irradiation the value increased to 9 per cent. Development of the drug resistance in the microbes neither after the single nor after the three-fold irradiation was observed.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.