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Biomedical subjects

V V Potin

Publications and source records attributed to V V Potin.

12 recordsLinked to original sources
PubMed1991

[Ovarian steroid synthesis in tissue culture after administration of hormones and epidermal growth factor].

The features of steroidogenesis of immature mouse ovaries in culture under the influence of follicle-stimulating hormones (FSH), human chorionic gonadotropin (hCG), epidermal growth factor (EGF) and insulin have been investigated during the period of reinitiation of meiosis in the oocytes. Secretion of progesterone is stimulated after addition of FSH, hCG and of insulin and EGF combination to the medium. EGF increases FSH-stimulated progesterone secretion and inhibits estradiol secretion. The ratios progesterone/estradiol and testosterone/estradiol increase, when EGF is added to the culture medium. It is analogous to the action of hCG. It is suggested that EGF may be an intrafollicular EGF regulator of luteinizing hormone action on the sex and somatic cells of the mammalian ovaries.

Animals↗
PubMedDate not supplied

[Impulse secretion of gonadotropins in patients with various forms of amenorrhea].

Circahoral variations of gonadotropin secretion were investigated in 5 healthy women in the follicular phase of the menstrual cycle, in 8 patients with normogonadotropic amenorrhea, in 6 patients with hyperprolactinemic amenorrhea, in 4 patients with hypogonadotropic amenorrhea, and in 10 patients with amenorrhea associated with body mass deficiency. The levels of LH, FSH, prolactin, estradiol and progesterone were determined by radioimmunoassay every 20 min for 4 hours. The results suggest that the blood levels of gonadotropins in different types of amenorrhea are determined mainly by an amplitude of their impulses.

Adolescent↗
PubMedDate not supplied

[The clinico-pharmacological characteristics of anteovin].

The clinical and laboratory studies carried out on 160 women showed a high contraceptive effect and good tolerance of anteovine. The contraceptive effect of the biphasic drug is determined by its antiovulatory action concurrent with inhibition of the basal periovulatory secretion of gonadotropins and secretion of sex hormones.

Adolescent↗
PubMedDate not supplied

[Treatment of diffuse toxic goiter with radioactive iodine in combination with prolonged antithyroid therapy].

The authors analyzed clinically the results of treatment of 237 patients with diffuse toxic goiter with radioactive iodine in combination with prolonged antithyroidal therapy (12--18 months). The advantages of combined therapy consisted in the use of relatively low 131I doses, a great frequensy of clinical remissions of thyrotoxicosis (83%), in the absence of thyrotoxicosis remissions after the administration of a low radioactive iodine dose and a low percentage of stable hypothyroidism development (0.8%) as a complication of radioiodine therapy.

Adult↗