Biomedical subjects

V V Pliatsko

Publications and source records attributed to V V Pliatsko.

At least 19 recordsLinked to original sources

PubMed1992

[Deforming gonarthrosis (questions of pathogenesis)].

Based on the biochemical, morphological, radionuclide, electron microscopy and arthroscopic data it has been established that there are significant changes in collagen proteins of the joint cartilage in the first stage of gonarthrosis deformans when degenerative and dystrophic alterations can only be seen in the joint cartilage. The determination of type II collagen which is commonly called procollagen brings something new in the understanding of the mechanism of degenerative dystrophic alterations in the joint cartilage. A considerable increase of a local proteolytic activity has been ascertained, which should be considered as the result of deep redox processes in the cartilage tissue. Gonarthrosis-associated microcirculatory disorders in the epiphyses with the development of vascular stasis, thrombosis, mural and total erythrocyte microaggregation cells, and perivascular hemorrhages have been confirmed. For the first time two forms of gonarthrosis (acute and latent) have been defined arthroscopically. The pathogenetic treatment methods have been elaborated in terms of the stages of the morphological changes identified.

Arthritis↗

PubMed1990

[Pathogenesis of arthrosis deformans of the knee joint].

The authors have studied the biochemical characteristics (type, aminoacid composition, carbohydrate component content) of the collagene proteins in the articular cartilage in normal conditions and in various expression of deforming arthrosis of the knee joint. The results (collagen of the its type formation, disturbances in the aminoacid composition of collagen of the 1st and 2nd types, changes in the carbohydrate component content, accumulation of procollagen of type 2) allowed to suggest that already at the early stages of development of deforming arthrosis there are distortion of synthesis and disturbance in postsynthetic transformations of the collagen proteins of hyaline cartilaginous tissue which lead to disturbances in the structure and in the function of the matrix and progressive degradation of the articular cartilage.

Adolescent↗

PubMed1990

[Changes in the synovial medium in deforming gonarthrosis].

The authors have determined the changes in the synovial medium of the joint characteristic of various stages of severity of the disease in 248 patients with deforming gonarthrosis on the basis of arthroscopic and thermographic studies and investigation of the permeability of the synovial membrane in the complex with clinical and roentgenologic examinations. At the initial stages the signs of local reactive inflammation of the synovial membrane near the foci of degeneration of the articular cartilage prevail. For the late stages a trend to spreading of the reactive inflammation of the synovial membrane with the development of sclerotic changes in the previously affected areas is characteristic. A comparison of the results of arthroscopy, infra-red thermography and the permeability of the synovial membrane point at parallel changes in the synovial medium and in the microcirculatory and regional circulation of the knee joint. These findings may be used for working out the rational tactics of treatment of the patients with deforming gonarthrosis.

Adolescent↗

PubMed1989

[Clinical, x-ray and arthroscopic parallels in initial stages of deforming arthrosis of the knee joint].

The study is based on the results of a clinical, roentgenologic and arthroscopic examination of 166 patients at the early stages of development of deforming arthrosis of the knee joint. The peculiarities of the early clinical, roentgenologic and arthroscopic symptoms and their relationship with the causative factors of the development of the disease have been investigated. The parallels between clinical and roentgenologic manifestations have been determined with regard to the degree of the degree of the degenerative and dystrophic changes in the articular cartilage, which is of major importance for the early diagnosis and the development of rational treatment of this pathologic condition.

Adolescent↗

PubMed1989