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Biomedical subjects

V V Pavlov

Publications and source records attributed to V V Pavlov.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Kidney function during radiosensitization with metronidazole].

Renal function was studied in patients with laryngeal cancer during radiation therapy performed under the conditions of mean fractionation in the presence of metronidazole radiosensitization up to the summary focal dose of 20 Gy. As compared to the findings before treatment an increase in the level of residual nitrogen, urea, uric acid and a decreased amount of creatinine in the plasma were noted. Decreased clearance of the urea, elevated Ambard's urosecretory constant were observed. The nature of these shifts was preserved even after the termination of subsequent radiation therapy up to the summary focal dose of 32 Gy without using the radiosensitogen. There is a possibility of a direct toxic effect of metronidazole on the renal tissue regardless of the state of oxygenation.

Blood Urea Nitrogen↗
PubMed1984

[State of the liver after radiotherapy of cancer of the stomach and larynx with metronidazole radiosensitization].

The use of metronidazole in radiation therapy of laryngeal cancer (SFD = 20 Gy) as a radiosensitizer of tumor hypoxic cells resulted in changes of the liver function tests: a decrease in the cholinesterase activity, a decrease in the level of cholesterol and albumin esters in the blood serum that characterize synthetic liver function. Similar though more noticeable in amounts shifts were marked in stomach cancer patients following preoperative irradiation (SFD = 20 Gy). A slight decrease in AP activity and a decrease in LDH activity below the initial level were simultaneously noted in the latter group as opposed to the group of laryngeal cancer patients. The deviations from the initial level of such liver function indices as bilirubin and total protein level, alanine and asparagine aminotransferase activity did not depend on the incorporation of metronidazole in the radiotherapeutic scheme and developed one way in the intervention and control groups of patients disregarding tumor site. The comparison of shifts of the liver tests in stomach and laryngeal cancer patients in whom tumor site was responsible for the incorporation of the liver in the irradiated zone or for the distance from it, made it possible to regard MZ direct toxic effect and its radiosensitizing effect on the hepatic tissue as causes of the observed deviations.

Humans↗
PubMed1984

[Medullary hematopoiesis in laryngeal cancer during radiotherapy using metronidazole].

To investigate the blood system response to the use of radiation therapy with metronidazole as a radiosensitizer, a study was made of the peripheral blood and bone marrow (at the light and electron microscopy level) in 46 patients with laryngeal cancer who had been subjected to local therapeutic irradiation at a summary focal dose up to 32 Gy. Twenty-eight patients received radiotherapy in the presence of a radiosensitizing effect of metronidazole, the others without a modifier. The patients ranged in age between 30 and 65. It has been shown that the medullary hemopoiesis of patients with laryngeal cancer is characterized by a considerable variability of the main indices: from hyperplasia of the hemopoietic tissue to the depression of myelopoiesis. The general signs of the bone marrow state were the intensity of erythropoiesis, high lymphocyte, monocyte, reticular and plasma cell counts, change of the partial morphograms of granulocytes and erythrokaryocytes that attest to the inhibition of the maturation of myelokaryocytes. The use of metronidazole as a radiosensitizer as distinct from purely radiation effects results in a high leukocyte count at the expense of the proliferating pool of the granulocytic growth of the bone marrow as well as in a larger share of ineffective erythropoiesis with a corresponding decrease of red blood indices. The disturbances revealed do not restrict indications to the use of metronidazole as a radiosensitizer.

Adult↗
PubMed1984

[Radiosensitivity of stromal mechanocytes in human bone marrow and spleen].

The monolayer cultivation of the bone marrow and spleen from patients with Hodgkin's disease was done. The content of stromal precursor cells (CFU-F) varies significantly in the human spleen (1.2-26.4 per each 10(6) incubated in the culture of nucleated cells) and is approximately one order lower than in the bone marrow (2.1-53.8 per 10(5) myelokaryocytes). During exposure to 60Co gamma-rays the values of a mean lethal cell dose (D0) for splenic CFU-F proved to be higher (2.03 +/- 0.17 Gy) than those for CFU-F from the bone marrow (1.49 +/- 0.12 Gy).

Bone Marrow↗
PubMed1984

[Supraventricular tachycardia caused by dual conduction paths in the atrioventricular junction].

An intracardiac electrophysiological study of 23 patients with a history of frequent attacks of supraventricular tachycardia showed that one of the underlying mechanisms of tachycardia development was reciprocation in the atrioventricular conjunction caused by binary conduction occurring in this structure (longitudinal dissociation). Two electrophysiological variants of reciprocal atrioventricular tachycardia were identified, namely ortho- and antidromal. The electrophysiological criteria for the diagnosis of both variants of reciprocal atrioventricular tachycardias are presented.

Adolescent↗
PubMed1983

[Evolution of a morphological variant and the prognosis in lymphogranulomatosis].

The authors present the results of a retrospective analysis of the clinical peculiarities of a course of Hodgkin's disease (HD) as compared to the results of histological examination of lymph node biopsies taken for diagnostic purposes and operative material from 235 patients after exploratory laparotomy with splenectomy. It was shown that rapid transformation (from the onset of disease) of the HD histological variant of the type of "lymphoid prevalence", "nodular sclerosis" or "mixed cellular" into the "lymphoid depletion" variant attests to high rates of the evolution of a tumor process and makes it possible to recognize the subacute nature of a course of disease before treatment. The above phenomenon points to poor prognosis and should be considered in the choice of therapeutic tactics.

Adult↗
PubMed1979

[Sutureless ultrasonic hermetic sealing of the bronchial stump after experimental and clinical lung resection].

The authors have shown the possibility of the hermetization of the bronchial stump after resection of the lung through the use of osteocyanacrlic mass treated with ultrasound. A small number of clinical reservations, however does not allow to recommend the method for a broad use in the clinical practice. Nevertheless the authors believe the idea of ultrasound sutureless closure of the bronchial stump to be a promising one and needing further studies.

Animals↗