[Changes in corticosteroid and catecholamine metabolism accompanying acute restrictions of mobility].
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Biomedical subjects
Publications and source records attributed to V V Parin.
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Current life-support systems of the spacecraft provide human requirements for food, water and oxygen only. Advanced life-support systems will involve man as their main component and will ensure completely his material and energy requirements. The design of individual components of such systems will assure their entire suitability and mutual control effects. Optimization of the performance of the crew and ecological system, on the basis of the information characterizing their function, demands efficient methods of collection and treatment of the information obtained through wireless recording of physiological parameters and their automatic treatment. Peculiarities of interplanetary missions and planetary stations make it necessary to conform the schedule of physiological recordings with the work-and-rest cycle of the space crew and inertness of components of the ecological system, especially of those responsible for oxygen regeneration. It is rational to model ecological systems and their components, taking into consideration the correction effect of the information on the health conditions and performance of the crewmen. Wide application of physiological data will allow the selection of optimal designs and sharply increase reliability of ecological systems.
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The paper presents the data of medical monitoring and physiological research carried out during the flights of V.F. Bykovsky, V.V. Tereshkhova and partially of G. Cooper. The results of measurements of hygienic parameters and microclimate testify to good reliability of life-support systems employed aboard the spacecraft. The analysis of the information of medical monitoring and physiological investigations allows the conclusion to be made that 5-day manned space flight causes no pathological changes. No essential peculiarities related to tolerance of flight factors by woman as compared to man have been revealed either. In conclusion the authors formulate basic tasks confronting physicians in performing physiological and hygienic investigations to promote further development of manned space flight.
Results are given of biological experiments on space ship-satellites II, III, IV and V, and of scientific investigations made during the flights of Cosmonauts Gagarin and Titov aboard space ships Vostok I and Vostok II. Physiological reactions to the action of the flight stress-factors are not of a pathological character. In the post-flight period no alterations in health conditions of either cosmonauts or animals were observed. At the same time some peculiarities which were revealed while analyzing physiological reactions and a number of biological indices require further investigations. The most important tasks remaining are to study the influence of protracted weightlessness, of the biological action of space radiation, of the action of acceleration stresses after prolonged stay under zero-gravity conditions and also to analyze the influence on the organism of the whole combination of spaceflight factors, including emotional strain. In the Soviet Union, a great number of biological experiments have been conducted with a view to elucidating the action of space flight factors on living organisms and the design of systems necessary to ensure healthy activity during flight aboard rocket space vehicles. The first flight experiments with animals were conducted by means of geophysical rockets. The next step in this direction was made by the launching of Sputnik II in 1957 and by experiments on space ship-satellites in 1960-61. The main purpose of flight and laboratory investigations was to obtain the objective scientific criteria essential for ensuring the safety of manned space flight.
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The neurotropic activity, toxicity and pharmacokinetics of triftazine in the form of syrup and powder were subjected to a comparative study on albino mice, rats and dogs. Investigations demonstrated that as follows from the tests under study these drugs display an egual depressing activity. Triftazine from the syrup was found to quicker enter the blood and was detected later in it (after 24 hours). The toxicity of peroral triftazine administered to mice and rats is the same for both dosage forms, it being somewhat higher for intraperitoneal triftazine syrup.