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Biomedical subjects

V V Murashko

Publications and source records attributed to V V Murashko.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Relation between features of the psychoemotional status and lipid metabolism of patients with ischemic heart disease and arrhythmias].

Interrelationship of the peculiarities of the psychoemotional status, the activity of lipid peroxidation and the content of blood free fatty acids were studied in 64 CHD patients with arrhythmia. It was shown that prolonged and pronounced psychoemotional strain, high levels of the activity of free radical lipid oxidation and the content of nonesterified fatty acids in the blood of CHD patients promoted the development of cardiac rhythm disturbances, particularly of ventricular extrasystoles. Patients with the psychoemotional strain syndrome demonstrated direct correlation of an induced initial hemiluminiscence flash value and the level of a psychological pattern MMPI by scales 2, 6, 7, 0, as well as close direct correlation of the concentration of free fatty acids with scales 6, 8, F and negative correlation with scale 3. The detection of the psychoemotional strain syndrome in CHD patients, especially in combination with high levels of lipid peroxidation and nonesterified fatty acids in the blood, may evidently serve an important criterion for defining patients at high risk of developing arrhythmias.

Arrhythmias, Cardiac↗
PubMed1985

[Immunochemical study of the alpha 2-glycoprotein from the atherosclerotically altered aortic wall in the blood serum of ischemic heart disease patients].

A study was made of the level of alpha- and beta-lipoproteins, apolipoprotein H and tissue protein alpha 2-glycoprotein of the arteriosclerotically changed aortic wall in the blood serum of 129 patients with coronary arteriosclerosis, 50 patients with various diseases of the internal organs without clinical signs of arteriosclerosis and in 26 healthy patients by the immunodiffusion method using standard assays. A significant increase in beta- and alpha-lipoprotein indices was revealed in the groups of patients with coronary heart disease as compared to the healthy persons. alpha 2-glycoprotein of the arteriosclerotically changed aortic wall was undetectable in the blood serum of the healthy persons; in the group of patients without clinical signs of coronary heart disease this protein was detected in 5 patients only in the concentration of 4-8 micrograms/ml. alpha 2-glycoprotein concentration in the blood serum of the patients with the ischemic, thrombonecrotic and fibrous stages of arteriosclerosis was much higher (23.5 +/- 1.0; 27.5 +/- 2.9 and 35.3 +/- 2.2 micrograms/ml respectively). The proposed immunochemical determination of some indices of the blood serum can be of use to assess the activity of arteriosclerotic processes in patients with coronary heart disease. The determination of the level of alpha 2-glycoprotein of the arteriosclerotically changed aortic wall serves this purpose most adequately.

Adult↗
PubMed1985

[Blood viscosity indicators in patients with gastric and duodenal diseases].

A total of 102 patients with peptic ulcer of the stomach and duodenum, chronic gastritis, and erosive gastritis were examined. A statistically significant increase in blood viscosity was recorded during the diseases enumerated. In peptic ulcer and chronic gastritis, the fibrinogen and hematocrit levels did not change quantitatively although quantitative changes in the fibrinogen level were likely to influence blood viscosity. Red cell aggregation was found to be increased, being the main factor responsible for blood viscosity deterioration. The authors studied the effect of cimetidine on blood viscosity in patients with peptic ulcer and the effect of peritol in chronic gastritis. These drugs were found to markedly reduce blood viscosity, as a result of which the circulation in the gastric mucosa improved, promoting the cure of patients with peptic ulcer. According to the authors' opinion, cimetidine, that blocks H2 histamine receptors, lessens the effect of histamine on red cell aggregation, thereby improving blood viscosity.

Adolescent↗
PubMed1985

[Change in blood rheological properties in response to graded physical exertion in patients with ischemic heart disease and persons at risk].

Blood rheologic properties were investigated before and after rationed exercise in 26 patients exhibiting risk factors unattended by atherosclerotic signs, 33 coronary patients and 26 normal subjects. Hemorheologic changes in response to bicycle ergometry were shown to depend largely on the efficiency of cardiac performance and be more marked in coronary patients and those exhibiting risk factors, as compared to normal subjects. In addition, the erythrocyte aggregation coefficient increased significantly during rationed exercise in coronary and risk-factor patients, in contrast to normal subjects. It is suggested that disorders of blood viscosity and erythrocyte aggregation, developing in part of coronary and risk-factor patients, may be conducive to the progress of atherosclerosis and coronary heart disease.

Adult↗
PubMed1984

[Incretory function of the pancreas and carbohydrate metabolism in patients with peptic ulcer of the duodenum].

Examination of 84 patients with peptic ulcer of the duodenum demonstrated that the majority of patients had alterations in carbohydrate metabolism manifested by fasting hypoglycemia, slow increase in glucose and hyperglycemia at the 180th minute during making the glucose tolerance test. The level of immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) was discovered to range within wide limits, namely from low basal secretion to hyperinsulinemia and hyperglucagonemia at the end of examination with the use of the glucose and insulin tolerance tests. During making the glucose tolerance test, the changes in IRG concentration were more demonstrable. The changes in hormone secretion were recorded if the disease lasted long and did not depend on the stage of the process. IRI and IRG secretion was determined by both the glycemia level and concentration of the hormones themselves, by their mutually correlating influence and was aimed at the maintenance of glucose homeostasis in patients presenting with peptic ulcer of the duodenum.

Adult↗
PubMed1984

[Erythrocyte membranes during malignant growth].

Suspensions of red cells from normal subjects and cancer patients were incubated in the presence of hydrogen peroxide. The incubation gave rise to a flash of chemiluminescence including rapid and slow components. The concentration dependencies of chemiluminescence were plotted as was the dependence of chemiluminescence on the temperature of the suspension under test. The differences were found between chemiluminescence of donors' red cells and that of patients'. It is inferred that red cell membranes of cancer patients show both the decreased membrane resistance to the damage-inducing action of hydrogen peroxide and elevation of antioxidant activity.

Erythrocyte Membrane↗