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Biomedical subjects

V V Lebedev

Publications and source records attributed to V V Lebedev.

At least 37 records · Page 2Linked to original sources
PubMed1993

[The clinico-angiographic manifestations of vascular spasm in the acute period of an aneurysm rupture].

The clinical picture was compared to angiographic findings on the spasm in 85 patients in acute period of an aneurysmal rupture in the absence of the intracranial hematoma. Spasm-induced ischemia was responsible for cerebral dysfunction and neurological symptoms. Days 5-13 since the aneurysmal rupture can be viewed as a functionally significant spasm interval. To prevent repeat hemorrhages and brain ischemia, aneurysmal intervention should be conducted on early hours and days of the disease, before or during a less severe vascular spasm.

Acute Disease↗
PubMed1991

[Clinical aspects and diagnosis of arteriovenous malformations in the acute stage of hemorrhage].

The authors describe the clinical picture of the rupture of arteriovenous malformations and a complex of diagnostic measures which permit the diagnosis of arteriovenous malformation to be established in the acute stage of hemorrhage. The rupture of such malformation including intracranial hematomas and blood tamponade of brain ventricles could also be ascertained. Early diagnosis of the rupture of arteriovenous malformations enables one to define the surgical policy, to choose the time and scope of surgical intervention.

Carotid Arteries↗
PubMed1990

[Immunomodulating properties of leukinferon].

Tolerance and immunomodulating properties of leukinferon for injections were studied in 13 healthy volunteers. The drug was administered by inhalation and intramuscularly in a single dose of 10,000 MU twice daily for 3 days. Intramuscular injections of the drug were accompanied by a number of side effects: pyrogenicity, weakness, headache, that ceased 8-12 hrs after the drug was discontinued. Despite these side effects, the drug was satisfactorily tolerated. Neither viscera nor systemic disorders nor allergic reactions were detected. T-lymphocytes proved to be the most sensitive to the drug. Leukinferon was found to activate the interferon system. The effect was the most marked in respect of IRL-gamma.

Adjuvants, Immunologic↗
PubMed1989

[Modifications of cytochemical methods of detecting alkaline and acid phosphatase activities of leukocytes].

Wide use of the detection of the leukocytic alkaline and acid phosphatase (AIP and AP) activities by the azo coupling method has necessitated the development of rational modifications of the routine methods. When staining just few smears, it is recommended that the neutrophilic AIP activity be detected by applying the incubation medium onto the filter paper covering the blood smear; such a modification, used for the staining of 1-6 blood smears, reduces the reagent consumption by 5-6 times and is time-saving. The modification of the method for the detection of the leukocytic AP activity involves the use of the diazole blue O stain manufactured in this country; the acetate-veronal buffer (containing sodium diethylbarbital) is replaced by citrate buffer, pH 6.4. The leukocytic AIP and AP activities, determined in the blood smears stained according to the suggested and routine methods, coincide (p greater than 0.05).

Acid Phosphatase↗
PubMed1989

[ECG changes in subarachnoid hemorrhage of non-traumatic origin].

The assessment of ECG in patients with nontraumatic subarachnoid hemorrhages demonstrated 5 characteristic patterns of ECG change. They were shown to be secondary to cerebral pathology. Preoperative heart rhythm changes are not stable or life-threatening, whereas intraoperative arrhythmias, high-grade ventricular extrasystoles in particular, may prove fatal. Preoperative ECG changes, including "pseudoinfarction" ones, do not affect cardiac output or arterial blood pressure, so that no special treatment is required, nor is surgery contraindicated.

Adult↗
PubMed1989

[Clinico-anatomic correlations in traumatic ventricular hemorrhage].

A total of 265 patients with intracerebroventricular hemorrhages were investigated for correlation between clinical manifestations and craniographic, echoencephaloscopic and cerebral angiographic data and brain pathomorphology. Intracerebroventricular hemorrhages were found in cases of severe craniocerebral trauma complicated, as a rule, with skull bones fractures, polar-basal cantusional foci, and intracerebral (rarely meningeal) hematomas. Relationship was established between the severity of craniocerebral lesions and intesites of intracerebroventricular hemorrhages which varied in character depending on the volume of adjacent intracerebral hemorrhage and the area covered by contusional polar-basal foci.

Adolescent↗
PubMed1989

[ECG changes in ruptured cerebral aneurysm].

With ECG of the patients with arterial brain aneurysms ruptures analyzed in the pre- and postsurgical periods, 5 characteristic types of changes could be identified. Functional (secondary) nature of ECG changes was established and their dependence on the severity of the patients' state, aneurysm localization, disease duration, presence of angiospasm and intracranial hematoma were evidenced. The increase in the markedness of ECG disorders did not correspond to hemodynamic impairment. ECG changes are no contraindications for urgent surgery of the aneurysm. Nevertheless, distinct ECG changes were noted which could serve as prognostic criteria for the fatal outcome of the surgery.

Adult↗
PubMed1988

[Optimization of treatment of patients with insulin-dependent diabetes mellitus using multiple injections of insulin].

The use of various regimens of multiple insulin injections versus the regimen of a single injection resulted in more stable compensation of diabetes mellitus (glycemia stabilization), a decrease in insulin demand, smoothing over circadian glycemic variations, and correction of hypoglycemia. A choice of the number of injections and the time of administration depended on the type of a diabetic course, individual features of the patient's life style and work.

Adolescent↗
PubMed1988

[Phenotypic correction of the immune response by L-tyrosine in mice reacting oppositely to sheep erythrocytes].

The possibility of transversion of low-reacting mice into high-reacting ones evaluated by the application of the natural immunostimulators. L-tyrosine and thymic polypeptides (taktivin) were compared by their ability for the phenotypical correction of the immune response of the oppositely reacting mice. It was established that under the application of L-tyrosine to oppositely reacting mice the phenotypical correction of the immune response is possible. The dramatic increase in AFC and the AFC-SI secreting IgM is observed in the mice, low-reacting to SRBC in comparison with the high-reacting lines.

Adjuvants, Immunologic↗
PubMed1988

[Recurrent hemorrhage in rupture of intracranial arterial aneurysms in the acute period].

An analysis of the course of the acute period of subarachnoidal hemorrhages has shown that in 26.5% of cases there were repeated hemorrhages, the mortality rate of such patients being 69.3%. The prognostic system based on the construction of a linear discriminant function makes it possible to predict the possibility of repeated hemorrhage or its absence with a 76.3% accuracy. Prediction of repeated hemorrhages from the arterial aneurysms may contribute to the correct selection of the scheme of treatment, including urgent surgical intervention.

Acute Disease↗
PubMed1987

[Informativeness of different methods of visual stimulation in optochiasmatic arachnoiditis].

A comparative assessment of the informative value of visual evoked potentials (VEPs) has demonstrated that registration of VEPs in response to a diffuse flash of light makes it possible to objectively evaluate the status of the visual analyzer and to trace the course of the development and regression of the pathological process. In a long-term period of the recovery of the visual function in order to elucidate fine mechanisms of visual perception and to achieve objective optical correction of visual acuity, it is advisable to use VEPs in response to a structural stimulus.

Arachnoiditis↗
PubMed1987

[Evaluation of the functional capacity of patients in the acute period of mild craniocerebral injuries].

An analysis of the results of a combined psychophysiological examination has demonstrated that the absence of marked clinical manifestations cannot be considered as a valid criterion justifying the denial or discontinuation of inpatient treatment. Hence, the results of psychophysiological examination may serve only as an additional criterion in the evaluation of the patients' condition.

Acute Disease↗