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Biomedical subjects

V V Korkhov

Publications and source records attributed to V V Korkhov.

At least 19 recordsLinked to original sources
PubMed1997

[Current trends in the diagnosis and therapy of colorectal cancer].

The report deals with the 30-year experience gained by the Department in the treatment of nearly 5,500 cases of tumors of large bowel. Radical surgery for colonic tumor was followed by lethality in 3.0 and 5-year survival-80.8%; rectal tumor resection-5.3 and 58.2%, respectively. Individually-tailored modalities have been devised for a spectrum of cases of colonic wall invasion and metastatic lesions in regional lymph nodes. A choice of sparing, extended and combined surgical procedures vis-a-vis these factors has been developed, the latter offering most advantage. Therapeutic strategies for hepatic metastasis have been worked out on individual basis.

Colorectal Neoplasms↗
PubMed1996

[A rational surgical procedure in diffuse polyposis and multiple primary cancer against a background of polyps of the large intestine].

Under examination there were 292 patients. An analysis of results of treatment enabled the authors to conclude that surgical treatment of patients with diffuse polyposis of the colon is the method of choice. The method and volume of operations must be determined according to the involvement of the colon in polyposis, the age and state of the patients. The best method of surgery is a one-step radical operation-subtotal resection of the colon. Polyps concomitant to cancer of the colon should be ablated before the main operation since their histological analysis can change the volume of the planned radical operation. When choosing the method of surgical intervention for patients with primary-multiple cancer against the background of polyps the total portion of the colon with polyps should be ablated.

Colectomy↗
PubMed1995

[The surgical treatment of polyps and early forms of cancer of the large intestine].

The article describes the present-day principles of surgical treatment of polyps and early forms of colorectal carcinoma appearing against their background. The investigation performed has shown that all benign adenomas of the colon can be successfully treated by local dissection. Sessile tumors located on the lower- and middle-ampullar portions of the rectum, are liable to endorectal dissection, in pedicular tumors endoscopic polypectomy is most expedient. In cases with carcinoma against the background of adenoma, the main criterion determining choice of the method of surgical intervention is the degree of ingrowth of the tumor into the colon walls. An analysis of long-term results of treatment shows that in carcinoma of the colon developing against the background of adenoma, local dissection is not inferior in efficiency to typical radical operations.

Adenoma↗
PubMed1992

[Effect of a new prostaglandin aroxaprostol on the contractile activity of the uterus and its abortive action in experimental studies].

Experiments with pregnant and nonpregnant rats have shown that aroxaprostol, a group F2 alpha prostaglandin, injected intravenously and intramuscularly in a dose of 50 micrograms/kg, stimulates the uterine bioelectric activity, increasing both the amplitude and frequency of biopotentials, this evidencing intensification of its contractility. Aroxaprostol has shown an abortive effect, that was related to the luteolytic effect of the drug, manifesting by reduction of progesterone level in the ovaries.

Abortifacient Agents↗
PubMed1989

[The combined and separate use of prostaglandin and adrenergic agents for the purpose of the experimental correction of uterine contractile activity].

Experiments on pregnant rats revealed that a combination of low doses of partusisten and clophelin (1.25 mg/kg and 0.15 ml of 0.001% solution, respectively) potentiated a tocolytic effect. A combination of prostenon and oxytocin given in half doses (0.15 mg/kg and 0.25 IU in 0.1 ml, respectively) summarized their stimulant effect on the myometrium. Premedication with partusisten (2.5 micrograms/kg) failed to change the stimulant effect produced by a combination of prostenon and oxytocin given in half doses.

Animals↗
PubMed1988

[Relation of the progestagenic activity and conformation of the 17beta-acetyl side chain in the D'6-pentarane series].

The synthesis of 2' beta-methyl-16 alpha,17 alpha-cyclohexanoprogesterone and its MM2 conformational analysis have been performed. The acetyl side chain was shown to have an unusual conformation with the torsion angle C13-C17-C20-O20 being -32.1 degrees. This conformation is by 5.4 kJ.mol-1 more stable than the usual one with the torsion angle 130.3 degrees. 2' beta-Methyl-16 alpha,17 alpha-cyclohexanoprogesterone proved to be inactive as a progestogen (pregnancy maintenance and McPhail tests). The lack of the activity may be due to the additional methyl group in D'-ring causing a change of the conformation of the 17 beta-acetyl side chain, thus hindering the formation of the conformation necessary for binding to the progesterone receptor.

Animals↗
PubMed1986

[Progestagenic activity and the mechanism of the contraceptive action of mecygeprone].

Progestagenic activity of a modified analog of progesteron-6 alpha-methyl-cyclogexan-[1', 2', 16 alpha, 17 alpha]-pregn-4-en-3,20-dion including into mecygepron composition has been studied; its activity is proved to be 5 times as great as that of progesteron at any way of administration. Mecygepron affects processes of ovogenesis and early embryogenetic development in rats. A decreased number of washed out embryos is observed, while the number of lutein bodies specific for intact rats remains the same, decelerated rate of cleavage and increased number of unfertilized ova. In the mechanism of the changes observed an essential role plays a decreased secretion of lutropin resulting in a prolonged estrol cycle and, evidently, in intrafollicular overmaturation of the ova, which loose their ability to be fertilized. Besides, the disturbed hormonal balance under mecygepron influence can affect the character of the oviduct and uterine contents and, thus, prevent the normal development of the fertilized gametes.

Administration, Oral↗