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Biomedical subjects

V V Katsalukha

Publications and source records attributed to V V Katsalukha.

8 recordsLinked to original sources
PubMed2001

[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I].

The authors present results of studying the effectiveness of a new class of medicines--preparations of the group "Glutoxim" (Molixan, Redoxell, Bikvolit, Liglutin) obtained on the model of experimental cirrhosis of the liver in 76 white rats caused by dimethylnitrosamin, and describe their first experience with using thiopoietins in 24 patients with cirrhosis of the liver in a surgical clinic. It was found that three weeks of treatment with Molixan and Bikvolit gave a significant hepatoprotecting effect (less amount of the connective tissue, reduction of the dystrophic processes in hepatocytes). A positive effect of Redoxell was shown in longer time of treatment. When used in clinic therapy with thiopoietins was followed by correction of the T-cell link of immunity in most patients. One of the most important results of treatment with medicines of the group of thiopoietins was a substantial improvement of the quality of life of the patients.

Adult↗
PubMed1997

[Improvement of microbiological diagnosis of dysbacteriosis].

The study was undertaken to improve transport and selective culture media and a testing scheme for dysbacteriosis. Great emphasis is laid on methods for isolating and identifying the nonclostridial anaerobes which are the major component of the normal human intestinal microflora. The following media were proposed: a) a sterility-checking-up medium, hemin, vitamin K1, cysteine, and twin 80 was for transportation of samples to a laboratory; b) anaerobic blood-containing agar with selective additives (kanamycin and bile) for isolation of bacteroids; c) a propionic acid-containing medium for isolation of bifidobacteria; d) a acetic acid-containing medium for isolation of lactobacteria. The use of the above culture media, microanaerostats, and three-component gas mixture substantially enhanced the efficiency of microbiological diagnosis for intestinal dysbacteriosis.

Bacteria, Anaerobic↗
PubMed1994

[Comparative evaluation of the effectiveness of fluoroquinolones in experimental anthrax infection].

Comparative antibacterial activity and protective efficacy of ciprofloxacin, pefloxacin and lomefloxacin were estimated in a model of anthrax. The MICs of the three drugs determined by the method of serial dilutions for three vaccinal strains of Bacillus anthracis were 0.5 to 1.0 microgram/ml. The protective efficacy of the chemotherapeutics in experimental anthrax induced by the spores of the vaccinal strain 71/12, Tsenkovsky was evaluated in mathematically designed four-factor experiments. It depended on the infective dose and the chemotherapy term and amounted in the protective use of the drugs in the daily doses, equivalent to those for humans, to 80-100-percent protection of the animals infected with 10 LD50 of the biological agent, to 50-80-percent protection with the use of 100 LD50, to 40-70-percent protection with the use of 1000 LD50 and to 50-90-percent protection in the therapeutic use of the fluoroquinolones. This was indicative of the fact that the fluoroquinolones were chemotherapeutically highly active in the treatment of experimental anthrax. The marked therapeutic efficacy of the fluoroquinolones and the high percentage of the animal protection after their urgent prophylactic use in a single dose are their obvious merits. The total values of the protective efficacy of the three fluoroquinolones with respect to anthrax were practically the same.

Animals↗
PubMedDate not supplied

[Cytokinin inducing and antiviral activity of cycloferon on experimental herpetic infection].

Experimental data on the protective activity and the capacity for inducing the biosynthesis of some cytokins, the low molecular inductors of cycloferon, endogenic interferon of the acridanon group, in herpetic infection are presented. The herpes infection was modelled by intraperitoneal injection of herpes simplex virus, type 1 into BALB/c mice. In the animals with normal immune status cycloferon induced the formation of serum interferon (INF) in high titers (up to 1:20,000) with the peak achieved 4-8 hours after the injection of the preparation. In addition, cycloferon stimulated the synthesis of IL-2 and gamma INF, but decreased the concentration of IL-1b. Following immunosuppression caused by gamma-radiation or cyclophosphamide the titers of serum interferon decreased 4-8 times. In generalized herpes infection in non-inbred white mice with undamaged immune status cycloferon increased survival rate by 30-100% in comparison with the controls (untreated mice), while in case of immunosuppression the protective effect of this preparation was considerably lower. In infected mice the concentrations of gamma INF, IL-2, IL-1b were found to be elevated in comparison with their concentrations in healthy animals. In the course of the infectious process cycloferon suppressed the production of IL-2 and IL-1b, but did not influence the synthesis of gamma INF.

Acridines↗
PubMedDate not supplied

[The antiviral activity of inhibitors of ADP ribosylation in experimental alpha- and bunyavirus infections].

The prophylactic and therapeutic effects of ADP-ribosylation inhibitors, 3,N-acetylaminobenzamide and 3,N-butyrylaminobenzamide, were studied in mice inoculated with an alphavirus or a bunyavirus. Both drugs were shown to have high levels of antiviral activity when given as a single subcutaneous injection in a dose of 10 mg/kg while increasing the number of injections did not increase their efficacy or might even decrease it.

Adenosine Diphosphate Ribose↗