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Biomedical subjects

V V Ivanov

Publications and source records attributed to V V Ivanov.

At least 19 recordsLinked to original sources
PubMed2002

[Use of modern technologies and designing means for development of automated information systems for military medicine].

At present time, the intensive activity implementation of automated information systems (AIS) to the military medical establishment are observed. From design quality the successful functioning of the AIS depend on. The effective functioning and the interaction of the automated information technologies by specialists, which computers and telecommunications use for performance of the their purpose, are a goal of the design. Today, there are two classes" technologies for designing of the automated information systems of military medical application: conventional technology and integrated instrumental means technologies. In this article, the conventional technology and integrated instrumental means technologies are considered more detail. CASE-technologies (the functional-oriented and object-oriented approaches) and RAD (Rapid Application Development) are viewed.

Automation↗
PubMed1997

Kinetics of tert-butyl hydroperoxide decomposition in erythrocyte suspension.

The kinetics of tert-butyl hydroperoxide (t-BHP) decomposition was examined in erythrocyte suspension from C57B1/6 mice by the chemiluminescence method. The reaction with horseradish peroxidase, t-BHP (20 nmol/ml), and luminol was accompanied by a rapid chemiluminescence increase. The integral value of the chemiluminescence signal correlated with the t-BHP concentration at every moment of time. In the erythrocyte suspension, the half-life of t-BHP decomposition was 23.8 s. The decomposition rate significantly decreased after pretreatment of the erythrocytes with o-phenanthroline (0.1 mM), EDTA (1 mM), benzohydroxamic acid (0.1 mM) or adriamycin (30 microM). These effects were not associated with the changes in the glutathione peroxidase activity and, more likely, could be related to the modification of the membrane iron-binding sites. The influence of iron chelators on the kinetics of t-BHP decomposition suggests the existence of various Fe-binding sites, that can decompose organic hydroperoxides upon their interaction with cell plasma membranes.

Animals↗
PubMed1995

[GeneBee-NET: An Internet based server for biopolymer structure analysis].

A network server providing biopolymer structure databank retrieval as well as some other biocomputing procedures for Internet users is described. Its basic procedures consist in looking for sequence and 3D homologies (similarities). Found homologies are used for constructing multiple alignment, for predicting RNA and protein secondary structures as well as for constructing phylogenetic trees. Alongside traditional methods of sequence homology retrieval, a "matrix-free" (correlation) method is proposed. A similar procedure is used to locate protein 3D similarities. For novel procedures algorithm ideas and their possible applications are discussed. The service ideology is based on the interaction of server and client programs. The client program (GeneBee for IBM PC) can be used to form queries to the server as well as to manipulate a treatment result. In the absence of the client program the interaction with the server can be in the text mode. The E-mail and WWW addresses for the server are as follows: SERVE/INDY.GENEBEE.MSU.SU and WWW.GENEBEE.MSU.SU.

Amino Acid Sequence↗
PubMed1994

Autotransplantation of the greater omentum in the treatment of chronic lymphedema.

We evaluated the use of transplantation of the greater omentum in the management of chronic lymphedema in 21 patients. The omentum provides a large surface with fluid absorbing capability and potentially therefore is useful in management of patients with primary or hypoplastic peripheral lymphatics. Based on the angio- and lymphangio-architecture of the gastroepiploic architecture, we used large segments of greater omentum as a free autotransplant with microrevascularization to the femoral or axillary artery and vein thereby avoiding technical drawbacks of a pedicle graft with the feeding vessels traversing the abdomen. Elongation of the omentum must be done properly because omental lymphatic arcades do not consistently follow the blood vascular arcades in its more distal part. Accordingly, if not properly mobilized the blood supply may be retained whereas the lymph circulation is interrupted. We combined omental implantation with lymph nodal-venous anastomoses using an omental vein with a nearby systemic venous tributary. In 19 of the 21 patients followed from 3 months to 2 years after operation, remission of lymphedema was good (reduction in swelling more than 50%) in 14 patients and satisfactory in 5 (approximately 25-50% reduction in swelling) with improvement gradually increasing with the passage of time.

Adolescent↗
PubMed1994

[The effect of the activation of lipid peroxidation on the structure of extraembryonic organs and the liver in rats at different periods of ontogeny].

The influence of activation of lipid peroxidation (LP) on morphofunctional organization of extraembryonic compounds and liver on different stages of rat's ontogenesis was studied. It is found that LP-activation (paraquat injection) in late pregnancy leads to extensive vacuolization of trophoblastic and yolk sac cells. In the embryonic liver, the number of hemopoietic cells decreases. During the first days after LP activation in the liver of adult animals, enlargement of granular endoplasmic reticulum elements and their degranulation were revealed. In the liver cells of the offsprings, administered paraquat prenatally, signs of bile formation activation were detected.

Animals↗
PubMed1993

[Work capacity of miners in clearing stopes of coal mines of the Donets Basin, working at normal and high temperatures].

Structure of labour activity in miners is based on adequate adaptive behavioral reactions. It is demonstrated by avoidance and appetitive behavior as well as slow work rate in faces with high environmental temperatures. Natural adaptive behavior however do not prevent miners from functional overload leading to low efficacy and capacity for work. Duration of work in such conditions must be shortened. Which was recommended as prophylaxis of fatigue and overheating in miners.

Adaptation, Physiological↗
PubMed1993

[The effect of pro-oxidants on insulin secretion by the isolated rat pancreas].

The effect of pro-oxidants (tert-butyl peroxide and FeSO4) on rats perfusing isolated pancreas insulin secretion was studied. Pro-oxidants (10(-4) M) preperfusion during 20 minutes did not change significantly the basal insulin secretion and decreased glucose-stimulated secretion of the one. The content of pancreas TBA-active products increased twice after pro-oxidants effect and ratio of reduced and oxidized glutathiones liberation rates decreased from 2 to 0.5. The disturbance of hormone secretion as a result of decrease of Langerhans islets B-cells reduced glutathione pool is suppose to be one of the mechanisms of hypoinsulinemia development at host's states characterizing with lipids peroxidation activation.

Animals↗
PubMed1992

[Morphological evaluation of fetal development after administration of Poterium sanguisorba for correction of fetoplacental circulation].

Polyphenol preparation of Poterium sanguisorba was tried for the treatment of experimental pregnancy abnormalities. The teratogenic and embryotoxic effects of the preparation administered in a dose of 0.75 LD50 were studied. The therapeutic doses of the drug are characterized by an immunostimulating effect on the mother and help correct the fetoplacental circulation and improve the fetal morphofunctional status.

Animals↗
PubMed1991

Low-density lipoproteins interact with liposome-binding sites on the cell surface.

Under physiological conditions significant amounts of low-density lipoprotein LDL particles ar taken up by cells independently of specific high-affinity LDL receptors (apo-B receptors). Previously it was established that some cells contain surface sites capable of binding liposomes. We proposed that liposome-binding sites could contribute to LDL interaction with the cell surface via phospholipid molecules of LDL particles. To check this hypothesis we studied the competitive interaction of human LDL and DPPC liposomes with mouse embryo fibroblasts depleted of apo-B receptors by preliminary incubation with LDL. We have found that after removal of the liposome-binding sites from cell lamellae these areas of the cell surface lose their ability to bind LDL.

1,2-Dipalmitoylphosphatidylcholine↗