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Biomedical subjects

V V Davydov

Publications and source records attributed to V V Davydov.

At least 19 recordsLinked to original sources
PubMed1993

[Inhibition of mammary gland carcinogenesis using a tincture from biomass of ginseng tissue culture].

The influence of official drug bioginseng produced from cultivated cells of ginseng radix (Panax ginseng C. A. Mey) on carcinogenesis of the mammary gland was studied. Adenocarcinomas of the mammary gland were induced in rats by single intramammary injections of N-methyl-N-nitrosourea (MNU) at a dose of 1 mg per gland into the tissues of all 12 mammary glands. Bioginseng was given per os at a daily dose of 0.5 ml per rat for 27 weeks beginning 1 week after the MNU administration. Bioginseng and the control MNU-group decreased the incidence and multiplicity of the mammary gland tumors at 44 and 62% respectively. By radioimmune assay it was found that bioginseng normalised abnormally high level of estradiol in blood of rats treated by MNU.

Adenocarcinoma↗
PubMed1993

[The inhibition of the development of experimental tumors of the cervix uteri and vagina by using tinctures of the cultured-cell biomass of the ginseng root and its germanium-selective stocks].

The anticarcinogenic effects of bioginseng and two germanium-selective drugs produced by cultivating cells of ginseng radix (Panax ginseng C. A. Mey) in a conventional medium or in media containing organogermanium compounds were studied. Squamous-cell carcinomas of the uterus cervix and vagina were induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene in mice. The drugs of ginseng were used orally or intravaginally during a long period of time of the postinitiation stage of carcinogenesis. All the drugs used locally effectively inhibited the development of induced carcinomas of the uterus cervix and vagina. When orally used, the drugs of ginseng exhibited only an insignificant tendency to inhibit the carcinogenesis of uterus cervix and vagina. The anticarcinogenic effects of the compared drugs were similar.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1993

[The effect of malonic acid on the rate of fibroblast proliferation in culture].

The influence of malonic acid on the proliferation rate of cultured human fetal [correction of embryo] skin fibroblasts was investigated. Addition of malonate to the serum-less incubation mixture stimulated fibroblast proliferation. The maximum stimulation occurred in the medium at the 0.01 mM concentration of malonic acid. When the cells were cultured in the medium with serum, the influence of malonate on the cells proliferation increased.

Cells, Cultured↗
PubMed1992

[The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea].

The study was concerned with the inhibitory effect of officinal preparations of phytoadaptogenic drugs such as bioginseng and Eleutherococcus senticosus and Rhaponticum carthamoides root extracts on the carcinogenesis induced by transplacental administration of N-nitrosoethylurea. The phytodrugs were given orally over a year. The administration of the drugs was followed by longer survival of the rats and lower occurrence and/or multiplicity of tumors (mainly those of the central nervous system). The drugs were placed in the order of decreasing anticarcinogenic activity as follows: bioginseng, Rhaponticum carthamoides extract and Eleutherococcus senticosus extract.

Animals↗
PubMed1981

[Transport ATP-ase activities in different brain structures during development of experimental neuroses in rats].

Typical alterations in activity of transport ATPases were observed in crude mitochondrial fractions isolated from various rat brain parts after chronic stressor effects. In the acute period of stress reaction activity of Na+, K+-ATPase was increased in synaptosomes of frontal cortex, hypothalamus and hippocamp. The enzymatic activity normalized after chronic action of the stressor agents. But under these conditions the activity of Mg2+-ATPase was distinctly decreased in cortex, hypothalamus and in pons Varolii.

Adenosine Triphosphatases↗
PubMed1980

[Adenohypophyseal hormone and corticosteroid content in the blood and urine in light mechanical injury].

A considerably increased content of adrenocorticotropic, somatotropic and thyreo-stimulating hormones of the hypophysis in the blood serum, as well as corticosteroids in the blood and especially in the day urine was noted in 27 male patients with the first 4--8 days after light mechanical traumas not resulting in pronounced disturbances of homeostasis and having favourable outcomes. It has been shown that a simultaneous assessment of cortisole and corticosterone in the day urine is most informative among the studied forms of adrenal hormones (17-OCS, cortisole, corticosterone) in the evaluation of the functional state of the adrenal cortex and corticosteroid balance in the organism of the patients.

Adolescent↗
PubMed1979

[Effect of dibazol on the state of the hypophyseal-adrenal system in patients operated on under thiopental anesthesia].

In the observations over the patients subjected to operations on the limbs under thiopental narcosis and in the experiments on white rats exposed to a shockogenic trauma (by Kennon's method) it has been found that the prophylactic injection of 1--2 mg/kg dose of dibazol rises the non-specific resistance of the body. The hormones of the pituitary-adrenal system have been found to hold an important place in the mechanism of the effect of dibazol.

11-Hydroxycorticosteroids↗