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Biomedical subjects

V V Arkhipov

Publications and source records attributed to V V Arkhipov.

At least 19 recordsLinked to original sources
PubMed2005

[New methods of stroke prevention in patients with chronic brain ischemia stages II-III, accompanied by hypercholesterolemia].

The problem of cerebrovascular diseases prevention is currently urgent not only in neurology, but in the community as a whole, because of the leading rates of vascular diseases in population disability and mortality. Hypercholesterolemia is one of the corrected risk factors for the development of the given diseases. The results of the study of 109 patients with CBI, II-III stages, treated with the drug liprimar and a new physiotherapeutic device, the neutralizer of free radicals, for cholesterol level optimization are presented.

Aged↗
PubMed2005

[Methodological bases of early psychosocial rehabilitation of poststroke patients in neurological hospital].

Based on the principles of rehabilitation elaborated by M.M. Kabanov (partnership, multidirectional nature and intergrity of psychosocial efforts), the authors have worked out a model of a complex team (neurologist, psychiatrist, psychotherapist and all medical personnel of the neurological unit) biopsychosocial approach to early psychosocial rehabilitation of patients who survived acute) ischemc attack. During the period of 2001-2004, comorbid mental disorders of psychotic (36%) and neurosis-like (64%) types were found in 356 patients (132 male, 224 female aged 40-59 years, 60-79 years and over 80 years. The model of organization of psychiatric/psychotherapeutic care ("interaction-attachment") is presented. Using combined psychopharmacotherapy (sonapax, neuleptil, haloperidol, coaxil, cipramil, phenazepam, xanax, mexidol, nootropil, etc) and an adequate psychotherapy basing on the principle of simultaneous biological and social action on poststroke patients (or persons socially significant for them and unit personnel), it was possible to raise quality of neurological as well as psychopharmacological and psychotherapeutic, in case of comorbid mental disorders, care that proved to be a main factor of early inpatient stage of psychosocial rehabilitation. As a result, there was an improvement of quality of life of poststroke patients in disease-modified conditions of their further biopsychosocial being.

Adaptation, Psychological↗
PubMed2003

[Current principles in the organization of emergency surgical care in a large city].

The specific character of emergency surgical care requires a concentration of highly skilled specialists of various profiles on the basis of multi-type hospitals and using expensive modern, highly informative and less invasive methods of diagnosis and treatment. The using of multi-type hospitals for emergency medical care will allow the intensification of treatment, wide application of less invasive technologies that will result in the appearance of incentives and conditions to shorten the number of bed-days, restriction of groundless hospitalization and to improve the tariff politics in the system of compulsory medical insurance.

Emergency Service, Hospital↗
PubMed2002

[Structural and functional features of Epstein-Barr virus LMP-1 gene in patients with anaplastic carcinoma of the nasopharynx in Russia].

Epstein-Barr virus (EBV) is known to be closely associated with the development of anaplastic nasopharyngeal carcinoma (NPC) in some malignancy endemic regions in South-East Asia. LMP1 gene is one of the EBV latent genes, which encodes a latent membrane protein. LMP1 gene is thought to be a classical oncogene since it morphologically transforms cells in vitro and induces tumors in experimental animals in vivo. LMP1 is one of a few genes which is expressed in NPC tissues. It was first shown that C-terminus of LMP1 gene obtained from NPC patients in South-East Asia contained a deletion of 30 base pairs (bp). However, this deleted LMP1 gene was then found in the EBV isolates persisting among healthy virus carriers and patients with other EBV-associated abnormalities from both NPC endemic and non-endemic regions. The aim of this investigation was to accomplish a molecular biological analysis of EBV LMP1 genes obtained from Russian NPC patients. To this end, the authors isolated and sequenced the LMP1 clones amplified from the tumor tissues from 7 NPC patients at the N. N. Blokhin Russian Cancer Research Center and primary blood lymphocytes (PBL) from 6 healthy donors. As a result, the authors could not find the deletion of the above-mentioned 30 bp in NPC LMP1 clones, but could in one healthy donor (PBL-2). A functional analysis revealed no significant differences between LMP1 variants with or without 30 bp deletion in their capacity to activate NF kappa B and jun/AP-1 transcription factors. Nevertheless, Russian NPC-derived LMP1 variants as compared with those from PBLs featured some specific amino acid exchanges. These data indicate that the 30 bp deletion of LMP1 gene is not a factor that predisposes to NPC in Russia.

Adaptor Proteins, Signal Transducing↗
PubMed2001

[Functional furosemide loading test. Practical use in children with kidney diseases].

Diuretic and aciduretic reactions were compared in healthy children and children with various renal diseases using furosemide loading test. Diuresis, urinary pH, urinary excretion of titered acids and ammonium, and ammonium coefficient were evaluated in healthy controls, patients with chronic and acute renal insufficiency, convalescents after acute renal insufficiency and acute postinfection glomerulonephritis, patients with chronic pyelonephritis, interstitial nephritis, lipoid nephrosis, hematuric chronic glomerulonephritis, and patients with a solitary kidney. Diuresis, urinary pH, ammonium excretion, and ammonium coefficient are proposed as the main test parameters. Patients with the distal tubular acidosis syndrome formed a special group by the results of urinary pH measurements during the third hour of furosemide action. The test helps evaluate the severity of disease and predict its course.

Adolescent↗
PubMed2000

[Use of gas-current coagulation in the local treatment of gunshot wounds].

The article is devoted to the using of gas-current coagulation for treatment of gunshot wounds in experiment. A new technology of physical action on biological tissues allows the simultaneous performing of hemostasis, sterilization of the wound surface, dissection and evaporation of the tissue. The isolation of the wound surface from unfavorable aggressive factors of the environment due to the layer of thermal necrosis results in shortening the 1 phase of the wound process and in earlier development of its second phase. Healing proceeds by the type of productive inflammation. The use of the gas-current coagulation during the performing of the primary surgical treatment of gunshot wounds allowed to considerably reduce its time, improve its quality, substantially lessen the amount of infectious complications, considerably improve the indices of the wound process and results of treatment.

Animals↗
PubMed1994

[Croupous pneumonia: current problems and means for their resolution].

Croupous pneumonia makes up to 7-8% of all pneumonia cases in different regions of the country. 83 lethal outcomes have been studied. In 46 cases pneumonia was primary illness and the direct cause of death. In case a pneumonia is diagnosed an urgent hospitalization and penicillin treatment (maximum effect on pneumococcus is ensured with 1.8-2.4 million units per day) are necessary. For the prevention of acute cardiovascular insufficiency camphor is prescribed for 2-3 days. Mucolytic preparations and--after normalization of temperature--physiotherapeutic methods and therapeutic exercises are used for treatment. In 25-46.6% of lethal cases pneumonia is not diagnosed in their lifetime. Late hospitalization influencing illness's outcome takes place in 73% of cases.

Adolescent↗
PubMed1992

Effect of Galleria mellonella larvae preparation and honeybee products on cell cultures.

1. The action of the extract from larvae of the great wax moth Galleria mellonella L. used in Russian folk medicine was studied. 2. Two active components influencing the growth and morphological differentiation of cells in vitro were found. 3. The presence of these components in the extract was conditioned by consumption of honeybee products by Galleria mellonella larvae. 4. Cytotoxicity of honeybee products was studied.

Animals↗
PubMed1991

[The morphofunctional state of the neurons in the nodose ganglia of the normal vagus nerves and in experimental myocardial infarct].

Basing on a complex approach with the use of general morphological and morphometrical methods, a morphofunctional characteristics of the nodose ganglia neurons of the nervus vagus has been presented in 203 dogs, both normal and at an experimental myocardial infarction. The neurons in question react to the myocardial infarction with a complex of changes in the intracellular structure parameters and their chemical markers. Their manifestation degree is higher and lasts longer, when the myocardial infarction happens at day time.

Animals↗
PubMed1985

[Growth of lymphoid cell cultures of the Raji line in a medium containing low-molecular serum components].

The effect of fetal bovine serum ultrafiltrate, containing low-molecular components (lower than 14 000 D), on the growth of cultures of the lymphoid Raji cells and fibroblasts BHK-21 was studied. The growth of the former did not differ from that in the control (in the medium with the whole fetal serum), while the latter did not proliferate in the medium with the ultrafiltrate. Thus, the growth of the lymphoid Raji cells and fibroblasts BHK-21 is controlled by different serum components. The Raji cells were exposed to an ultrafiltrate (up to 14 000 D) of the adult animal serum whose growth stimulating activity is known to be lower than that of the fetal serum. After the removal of components with molecular weights higher than 14 000 D from the adult animal serum, the growth stimulating activity of such a serum was seen increased, but not up to the level of the fetal serum. BHK-21 cells did not proliferate in the medium with this ultrafiltrate. It is proposed that the increase in the growth stimulating activity of the whole bovine serum in respect to the Raji cells after the removal of the components with high molecular weights may be due to the removal of lymphocyte growth inhibitors whose activity depends on the age of the animal serving a donor of serum.

Animals↗
PubMed1982

[Fibroblast behavior in weak substrate adhesion].

Primary human embryonic fibroblasts and permanent line of fibroblasts BHK-21 were cultivated on the glass in the medium, containing bovine serum ultrafiltrate with the molecular weight of the components up to 70000 D, and on liquid perfluorocarbon, perfluorotributylamine in the normal growth medium. In both the cases one could observe a formation of aggregates, however, in the case of cultivating the primary fibroblasts on the glass the aggregation was much less pronounced. The formation of aggregates is considered to be the result of the reduced adhesion of cells to the substrate. In the first case the low adhesion is accounted for by the deficiency of the adhesion factors, and in the second case--by the physico-chemical properties of the liquid substrate used.

Cell Adhesion↗