[Current trends in the development of new blood substitutes].
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Biomedical subjects
Publications and source records attributed to V V Alekseev.
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The influence of acid exopolysaccharides of some Pseudomonas species on the viability and fractional disperse composition of Salmonella marcescens-9 aerosol under static conditions has been studied. Acid exopolysaccharides have been shown to form membranes around bacteria. These membranes, due to their adsorptive and water-retaining properties, seemingly enhance the viability of bacteria in aerosol, both in the process of its generation and during its suspension in the air under static conditions with different values of relative humidity.
The authors describe a case of angiographically verified arteriovenous shunting of the cerebral blood flow coupled with basal ++meningo-cerebral developmental abnormality and paraganglioma of the glomus jugulare in a 52-year-old patient. Such a unique combination made it possible to suggest the existence of potential mechanisms of blood flow shunting either via tumorous vessels or vessels (arteriovenous shunts) of the basal ++meningo-cerebral developmental abnormality. In the latter case, the shunts were likely to occur latently while the clinical manifestations of the disease might be related to the tumor growth, impairment of the venous outflow and disclosure of arteriovenous shunts.
Seventy patients with Stages I and II hypertensive disease underwent electrocardiographic studies of the emotional syndrome and central hemodynamics prior to and following reflexotherapy. Characteristics of the psychovegetative syndrome were identified in the patients. A significant antihypertensive effect and normalized psychological and vegetative parameters observed after reflexotherapy suggest that acupuncture is beneficial in the treatment at early stages of essential hypertension.
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EEG, central hemodynamic parameters and the emotional syndrome were investigated in 55 patients with labile hypertension. Two cerebrovegetative patterns corresponding to different degrees of cortical activation and different mechanisms controlling arterial blood pressure and anxiety levels were identified. As the two groups of patients did not differ in terms of age or duration of the disease, those could not be attributed to different stages of the disease, suggesting rather that sympathetic and parasympathetic vegetative nervous components may be making different contributions to the formation of hemodynamic type.
Central and peripheral hemodynamic effects of reflex therapy were assessed by means of echocardiography and rheovasography, as was the pulse rate, arterial blood pressure and peripheral vascular tonicity response to the baroreflex test in patients with neurocirculatory dystonia, the hypertensive syndrome and essential hypertension, stage IB-HA by L. A. Miasnikov's classification. The hypotensive effect and favorable central hemodynamic changes contribute to the recovery of an adequate pulse and blood pressure response to the baroreflex test, and a greater baroreflex test-induced drop in vascular tone.
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The results of an echocardiographic study of central hemodynamics and a rheovasographic study of vascular tonicity under the effect of reflex therapy in patients with essential hypertension (EH), stages IB-IIA, and those with neurocirculatory dystonia (NCD) associated with the hypertensive syndrome are reported. Initially, patients with NCD and EH, stage IB, showed hyperkinetic circulation, and those with EH, stage IIA, had hypokinetic circulation. The EH patients also exhibited elevated peripheral vascular tone. Minute volume of the heart was reduced in response to treatment in patients with NCD and EH, stage IB, and increased in those with EH, stage IIA in the presence of depressed BP. Peripheral vascular tone decreased in EH patients. Therefore, the two functional tests demonstrated the possibility of reflex control of hemodynamic disorders in hypertensive patients, with eukinetic circulation restored irrespective of their original nature.
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The antigenic composition of some cell structures of P. pseudomallei has been studied and the chemical nature of the antigens has been determined by the method of two-dimensional electrophoresis. In some cell components common antigens have been detected; at the same time these components have been found to possess their own characteristic antigenic complexes. The place of the cell structure antigens in the total antigenic structure of P. pseudomallei has been determined.
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Results of diagnosis and treatment of 1337 patients with esophageal and gastroduodenal hemorrhages were analyzed. The diagnostic and curative endoscopy is recommended. Variants of tactics of the operative and conservative treatment are proposed for the conditions of specialized hospitals of emergency medical service.
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