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Biomedical subjects

V Tchertkoff

Publications and source records attributed to V Tchertkoff.

At least 19 recordsLinked to original sources
PubMed1993

Giant collagen plaques in Creutzfeld-Jakob disease. Report of two cases with ultrastructural studies.

We report two cases of Creutzfeld-Jakob disease with clusters of giant collagen fibers. To our knowledge, these abnormally large collagen fibers have never been described in patients with degenerative diseases of the central nervous system. The significance of the formation of such plaque-like large collagen fibers has as yet not been elucidated. It is felt that these represent a product of the degenerative process.

Adult↗
PubMed1991

Histochemical determinations of copper, zinc, and iron in pigmented nevi and melanoma.

Histochemical determinations of copper, zinc, and iron in intradermal pigmented nevi and melanomas revealed the presence of copper and iron in melanoma but not in nevi. Zinc was not detected in either melanomas or nevi. However, melanin was removed from the tissues prior to staining; therefore, it is possible that zinc was also removed by the procedure. Although the function of copper and iron in the melanoma cell is not known, they may be components of abnormal enzymes.

Copper↗
PubMed1990

Chronic follicular pyeloureteritis.

A case of chronic follicular pyeloureteritis is presented. This rare lesion, not previously published in the American literature, must be differentiated from primary renal lymphoma and generalized malignant lymphoma of the nonHodgkin type.

Adult↗
PubMed1988

Invasive ovarian endometrioid adenofibroma with omental implants and collision with endometrial adenocarcinoma.

A case of endometrioid adenofibroma of the ovary with omental implants, extensive invasion into the wall of the ipsilateral fallopian tube, and collision with an endometrial papillary adenocarcinoma is reported. Fewer than 35 malignant cystadenofibromas and adenofibromas have been reported. In all of these cases, the malignant epithelium was believed to originate from preexisting benign tumors. This case is unusual in that it demonstrated no malignant epithelium beyond that of a borderline tumor, but met the criteria of malignancy because of its invasiveness and metastasis.

Adenocarcinoma↗
PubMed1986

Pseudogaucher cells in Mycobacterium avium intracellulare infections in acquired immune deficiency syndrome (AIDS).

This report describes a 28-year-old woman with the acquired immune deficiency syndrome (AIDS) with culture-proven disseminated Mycobacterium avium intracellulare infection. The histopathologic and cytologic features in this case were unique in that these organisms that stained positively with the Ziehl-Neelsen and periodic acid-Schiff (PAS) stains were numerous, present intracellularly within histiocytes, transforming them into pseudogaucher cells. Differential diagnostic criteria for pseudogaucher cells and abnormal macrophage handling of the intracellular organisms in AIDS are discussed.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Histochemical determination of copper, zinc, and iron in some benign and malignant tissues.

Histochemical tests for copper, iron, and zinc revealed their presence in the stratum germinativum of normal skin and skin from which an early melanoma and basal cell and squamous cell carcinomas originated. However, only copper was seen in invasive cells of basal and squamous cell carcinomas originating from skin. The normal oral mucous membrane was free of copper, iron, and zinc, but cells of invasive squamous carcinoma originating from the oral mucous membrane contained copper. The fluorescent brightening agent, applied as a counterstain, aided in the location of the specimen.

Basal Cell Carcinoma↗
PubMed1985

A testicular tumor resembling the sex cord with annular tubules in a case of the androgen insensitivity syndrome.

Sex cord tumor with annular tubules (SCTAT) is a distinctive neoplasm with indifferent cells of sex cord derivation in a characteristic arrangement of ring-like tubules. Much attention has been drawn to its association with the Peutz-Jeghers syndrome (PJS) with reported occurrence of the tumor in the testis of a boy with PJS. The authors present two cases of the androgen insensitivity syndrome (AIS), one of the cases being distinctive in having a large multicystic tumor resembling the SCTAT in the immature gonad. Additionally, the focal areas of the tumor, the large Sertoli cells lining the tubules, resembled those of a large cell calcifying Sertoli cell tumor (LCCSCT) although no calcific areas were discernible. Although the occurrence of neoplasms like germinomas and tubular adenomas is well known in the AIS, SCTAT has hitherto not been reported in a gonad of the AIS. SCTAT has been placed under an "unclassified sex cord-stromal" category in the World Health Organization (WHO) Classification, yet, opinions are divided as to its origin from a granulosa or Sertoli cell, although an overlap in the histologic features of the two cell categories is to be anticipated in view of their homologous nature. In the case presented, the close resemblance of the tumor cells to the Sertoli cells of the uninvolved gonad would further support the concept of a Sertoli line of differentiation of the SCTAT.

Adult↗
PubMed1985

Diffuse alveolar damage and interstitial fibrosis in acquired immunodeficiency syndrome patients without concurrent pulmonary infection.

Patients with acquired immunodeficiency syndrome (AIDS) characteristically present with repeated pulmonary infections. We present the pathologic findings in lung biopsy specimens from 12 patients with AIDS in whom the histologic spectrum ranged from mild diffuse alveolar damage to frank interstitial fibrosis. In all of these patients, there was no evidence of any concurrent infectious process in the lung. Diffuse alveolar damage is a pattern of response of the lung to many kinds of infectious processes and immunologic injury, both of which are potential possibilities in patients with AIDS. This study underscores the development of diffuse alveolar damage or interstitial fibrosis and their presentation as the sole histologic findings in lung biopsy specimens from patients with AIDS. We discuss the possibility that these changes may be long-term sequelae to repeated pulmonary infections with or without an immunologic defect.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Streptococcus equisimilis (group C) as a cause of ophthalmic infections.

The first two cases of human ophthalmic infections due to Streptococcus equisimilis (group C) are reported. This organism is known to produce severe infections in animals, but infection in humans is rare. The distinction between beta-hemolytic group C streptococci and group A and their ability to cause disease in susceptible patients is discussed.

Adult↗