Biomedical subjects
Publications and source records attributed to V Tatić.
Neurogenic tumors, primary bone tumors, are rather exceptional; about 50 cases have been reported so far. The study reports a case of intraosseous schwannoma, a primary bone tumor, in a 20-year-old male patient, localized in the distal end of the right tibia.
Soft tissue wounds were caused by penetration of a bullet through both thighs in 42 pigs, fired from N48, M70, M16A1 and FAL rifles at 50 meter range. Four comparable groups of wounds, consisting mainly of injured muscle, were examined. Primary debridement was carried out 5-6 hours following wounding, multiple muscle biopsies up to 40 mm sidewise of permanent wound channel were taken for HE and histochemistry. Primary contamination was traced using marker aerobic bacteria. Bullet velocities at impact and exit were measured and transfer of energy to liver tissue calculated when feasible. The condition of the bullet after exit was precised. The surgical estimation of tissue injury, the mass of excised tissue and microsections have served to evaluate the extent of tissue injury. For 22.5 cm mean channel length the most injury was caused by the FAL, followed by M16, M70 and M48 rifles in declining order. Local effects are ascribed to bullet tumbling, break-up and energy transfer of corresponding missiles. Correlation of surgical and pathology methods is discussed.
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Five cases of malignant bone fibrous histiocytoma diagnosed by bioptic material are presented. The authors state that the diagnosis of these rare bone malignant neoplasms do not present a larger diagnostical problem. However, some differential diagnostic problems are often met compared to other bone neoplasms, especially in osteosarcoma, so in these cases are recommended that together with routine histologic examinations in establishment of diagnosis should be also used enzymohistochemical methods, especially alkaline and acid phosphatase. Also, it is necessary to use immunohistochemical methods with corresponding markers which the authors have used in establishment of diagnosis of their cases. Based on the analysis of the presented cases the authors support the theory of J. Brooks on the histogenesis of these tumours within his theory of differentiation of the mesenchimal tissue which is easily recognized in recidives and metastases of soft tissue sarcomas by phenotypes organized at the lower level of differentiation.
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Histologic, histochemical and ultrastructural analyses were performed of the leaflets of all four heart valves in 50 subjects with acquired heart defects of noninflammatory etiology and 88 surgically removed damaged menisci without trauma anamnesis. On the basis of the detailed analysis some morphologic similarities were found in the heart valves and menisci such as myxomatous degeneration as the main pathologic lesion, lack of blood vessels in the altered tissues which point to noninflammatory nature of the lesion, similarity in nourishment by diffusion, degradation of the collagenous fibres which present the main histologic structure and the increased accumulation of acid mucopolysacharrides at the site of their degradation as well as the increased number of fibroblasts, that is, chondroid cells which are considered to excrete acid mucopolysacharrides. Sometimes these changes are hardly identify clinically, especially in meniscal diseases which could simulate rheumatic disease.
The analysis of 44 intracranial aneurysms found at 7.687 autopsies is performed. The largest number of aneurysms was of congenital (secular) type, then, of arteriosclerotic type while inflammatory and traumatic aneurysms were very rare. The elastic and reticular fibres in the aneurysmal wall and the normal arteries of the base of the brain were identified by a standard and special staining. Significantly decreased quantity and disturbed distribution of the reticular fibres were found in the congenital aneurysms which was considered to be a consequence of degenerative processes. The finding of the preserved elastic internal lamina in the wall of the congenital aneurysm and its absence or fragmentation in cases of arteriosclerotic aneurysms suggest the different etiology and pathogenesis of these aneurysms.
The authors have analysed 9 cases of Hürthle cell thyroid carcinoma diagnosed on the bioptic material in the period 1975-1991. In 7 patients subtotal and in 2 total thyroidectomy was performed. In one patient only signs of metastases of the tumour in the region of the mediastinum, neck lymphatic nodes and brain developed and the patient died a year after surgery. For differential diagnosis of Hürthle cell thyroid carcinoma and Hürthle cell adenoma the authors recommend as necessary that beside the presence of the basic criteria for malignancy (infiltration of the capsule and adjacent tissue, invasion of the blood vessels, pleomorphism and pathologic mytoses) the electron microscopic examination and immunohistochemical methods should be also used which could be of a great help for establishment of a correct diagnosis on which depends further therapy as well.
Four patients with tuberculous synovitis of the large joints are reported in whom primary tuberculous process has not been confirmed as a possible foci of spreading of the acidoresistant bacilli. The authors, describing in details the histologic picture of tuberculous synovitis, point out the importance of an early biopsy of the synovial membrane and obligatory microbiological confirmation of the established diagnosis.
The ultrastructural analysis of psoriatic dermal lesions has shown the alteration of the dermal arterioles into specialized postcapillary venules, the so called high endothelial venules (HEV) which are characterized by the presence of tannic acid staining materials (TASM) located among the endothelial cells. This type of venules seen in the lymphatic nodes and other lymphoid organs is considered to be an important site of lymphocyte recirculation. Similar venules are seen in the lymphatic nodes too. In correlation with the immunologic evidences in the lymphoid tissues and in psoriasis most probably in question are the identical surface antigen-lymphocyte receptors on the HVE which support selective binding of the definite subset of lymphocytes and migration from blood to tissues.