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V Tasch

Publications and source records attributed to V Tasch.

4 recordsLinked to original sources
PubMed1983

Chronic valproate administration reduces fasting ketonemia in children.

We previously found that chronic administration of sodium valproate to suckling infant mice reduced plasma beta-hydroxybutyrate levels but had no effect on plasma free fatty acid or glycerol concentrations. We now report that valproate has a similar effect in children taking the drug for epilepsy. In larger doses, valproate also depleted the infant mouse liver glycogen content. These findings may relate to the hepatic toxicity of valproate. We advise caution if the drug is being considered for use in chronically malnourished children or when the caloric intake of normal children is likely to be reduced during periods of acute illness.

Child↗
PubMed1981

Pharmacology of valproic acid in children with severe epilepsy: clearance and hepatotoxicity.

Valproic acid concentrations correlate with dose in children when sampling times are consistent. Both interpatient variability and average clearance of valproic acid are inversely related to age. Young children usually need higher doses to achieve the same blood levels as other patients, but the levels that result from a dose are less predictable from one child to the next. Whereas valproic acid therapy had little effect on the serum glutamic oxaloacetic transaminase (SGOT), 12% of patients had abnormal SGOTs during an average of 14 months' therapy. The abnormal SGOTs from patients without serious hepatic dysfunction overlap many of the abnormal values in cases of fatal hepatic failure associated with valproic acid.

Adolescent↗