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Biomedical subjects

V Taenzer

Publications and source records attributed to V Taenzer.

15 recordsLinked to original sources
PubMed1979

Double blind comparison of meglumine iotroxate (Biliscopin), meglumine iodoxamate (Endobil), and meglumine ioglycamate (Biligram).

Two new intravenous cholegraphic agents, iotroxate and iodoxamate, hold a lower general toxicity, lower protein binding, and claim a higher rate of biliary excretion. Both compounds proved to be equally effective in opacifying the gallbladder and the bile ducts in a double-blind clinical study comprising 400 cases. Iotroxate gave significantly earlier good or adequate visualization as a result of its higher excretion rate by the liver (P less than 0.05). Side effects were observed in fewer patients in the iotroxate group (11.6%) compared with the iodoxamate group (16.4%, P greater than 0.05). In a second double-blind study, an iotroxage group of 97 patients who received two thirds of the overall content of iodine (3.6 g) was compared with a group of 98 patients, who received ioglycamate (5.3 g). Visualization was equal in the two groups, while side effects were significantly reduced to 10.3% in the iotroxate group against 20.4% (P less than 0.05). The higher biliary clearance of iotroxate permits a reduction of the amount of iodine.

Adult↗
PubMed1977

[Pharmacokinetics and plasma albumen binding of iotroxic acid (Biliscopin), iodoxic acid (Endomirabil) and ioglycamine (Biligram) (author's transl)].

Pharmacokinetic data after injection of the new cholegraphic contrast medium iotroxic acid (Biliscopin) in man are reported and compared with the results of injections of ioglycamate and iodoxic acid. Iotroxic acid is less completely bound to plasma proteins than ioglycamate, but significancy more so than iodoxamate. Plasma protein binding depends on contrast concentration in the plasma, as does excretion in the urine. Biliary transport rate and maximal iodine concentration in the gall bladder are higher after injections of iotroxinate and iodoxamate than after ioglycamate.

Contrast Media↗
PubMed1977

[Angiographic findings in benign liver tumours (author's transl)].

Difficulties in the differential diagnosis of benign liver tumours and their differentiation from malignant liver tumours are discussed. Two patients with benign lesions were described, one with a liver cell adenoma, the other with a mixed cholangiohepato-adenoma (local nodular hyperplasia).

Adenoma, Bile Duct↗
PubMed1977

[Roentgenologic findings in carcinoma of the prostate (author's transl)].

Discussion of the radiodiagnostic findings in patients with carcinoma of the prostate, especially of tumor changes of prostatic ureterocystography. Lymphography was carried out in 154 patients with carcinoma of the prostate. Lymphnodes metastatic were found more frequently and earlier than skeletal metastases. A special lymphographic symptom is total metastatic replacement of lymphnodes by tumor spread.

Humans↗
PubMed1975

[False positive tumour diagnosis in the caecum(author's transl)].

Radiographic appearances simulating tumours were found in 25 patients; the causes of the mistaken diagnosis are critically analysed. The commonest mistake was caused by inflammatory process (eight patients), caecal contents (seven patients) and an enlarged ileo-caecal valve (five patients). Ways of avoiding such misinterpretation are described.author

Adult↗
PubMedDate not supplied

Biotransformation of ioglycamic acid, iodoxamic acid and iotroxic acid in man.

The biotransformation of the 131I-labeled cholegraphic media ioglycamic acid, iodoxamic acid and iotroxic acid in man is investigated. Plasma, urine and fistular bile were analyzed for unchanged and metabolized constituents of the administered substances using thin layer chromatography. No metabolites were found in plasma, but up to two were found in urine in addition to unchanged contrast media (a total of 50% of the total elimination in 24 hr. urine). A metabolite was only found in the fistular bile after the injection of iotroxic acid.

Biotransformation↗