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Biomedical subjects

V T Joseph

Publications and source records attributed to V T Joseph.

46 records · Page 3Linked to original sources
PubMed1983

Early gastric cancer in Singapore.

Gastric cancer is one of the commonest malignancies in Singapore. 330 to 350 new cases are reported annually. Only about 8% of these cases undergo curative resection and the rest receive some form of palliative surgery. Early gastric cancer (i.e., cancer limited to mucosa and submucosa) is rarely diagnosed in Singapore. This paper presents 11 cases of early gastric cancer treated successfully by various Departments of Surgery over the past 5 years. All patients are well and free of tumour to date. The aim of this presentation is to remind clinicians of the importance of detecting early gastric cancer which has more than 90% 5 year survival rate.

Adult↗
PubMed1983

One stage repair of hypospadias.

The surgical repair of hypospadias has evolved from the multi-staged procedures of the previous decade to single stage urethroplasty. A number of techniques have been described and this report is a study of the experience in 44 cases using 4 different types of repair. All patients were Chinese and their ages ranged from 1 year to 23 years, with about half the cases below 5 years of age. The most commonly used method of repair was the transverse preputial flap technique of Duckett (25 out of 44 cases). The overall results indicate a fistula rate of 20%. The detail correlation of complications with age, type of hypospadias and type of repair illustrate the general principle that while age is not a significant factor, with the more severe types of hypospadias, the complication rate is definitely increased.

Adolescent↗
PubMed1981

Undescended testis: a study of 212 cases treated surgically.

Two hundred and twelve of undescended testes were operated on in the Department of Surgery, Singapore General Hospital between the years 1974 through 1980. There was a 51.9% incidence of right undescended testis, 34.9% left undescended testis and 13.2% were bilateral. The method of treatment was surgical exploration with orchidopexy wherever technically feasible or orchidectomy if the testis was found to be severely hypoplastic. Of the total series, 42% were operated on before the age of 5 years. The oldest patient undergoing orchidopery was aged 40. Failure of orchidopexy to secure the scrotal position for the testis was noted in 14 cases. This was probably due to inadequate mobilisation at the first operation. There was no mortality and no significant morbidity following surgical treatment in this series.

Adolescent↗
PubMed1981

Malignant tumours of the undescended testis: a report of three cases.

Three cases of testicular malignancies arising in undescended testes were treated in the Department of Surgery, Singapore General Hospital. The patients were all adult Chinese male who presented with tumours arising in unilateral, intra-abdominal undescended testes. Two of the tumours were seminomas while the third was a choriocarcinoma. In all 3 cases, the tumours were large and at an advanced stage at the time of presentation. The treatment in these cases was surgical excision of the primary lesion followed by radiotherapy or chemotherapy. The patient with choriocarcinoma died soon after chemotherapy was initiated while the other two cases are alive, one for over 6 years with no recurrence.

Adult↗
PubMed1981

Infantile hypertrophic pyloric stenosis: surgical experience of 24 cases.

Twenty-four patients with infantile hypertrophic pyloric stenosis were admitted to the University Department of Paediatrics, Singapore General Hospital, from 1974 to 1980 were reviewed. The male to female ratio was 2.4:1. The age of onset of vomiting ranged from birth to 7-week. All except 2 had palpable pyloric tumour. Barium meal studies were required in these two patients to confirm the diagnosis preoperatively. Significant abnormal laboratory findings on admission were: metabolic alkalosis (71%), hypochloraemia (63%), hyponatraemia (54%), hypokalaemia (21%), haemoconcentration (39%) and pre-renal azotaemia (17%). Two-thirds of the patients were operated within 24 to 48 hours after intravenous correction of fluid deficit and electrolyte imbalance. Common complications after Ramstedt's pyloromyotomy were vomiting and fever which were, however, mild and subsided in two to three days. Serious complications were uncommon and there was no mortality in this series. Majority of the patients were discharged well after one to two weeks of hospitalization.

Adolescent↗
PubMed1981

Surgical experience with lymphangioma in infants and children.

Twenty-nine consecutive cases of lymphangioma seen and managed at the Department of Surgery, Singapore General Hospital, between August 1974 and January 1981 are reviewed here. More than half the lesions (58.6%) were noted at birth and about 90% presented during the first year of life. All patients were treated by surgical excision soon after recognition, in order to prevent extensive local growth and expansion which can encroach on vital structures such as nerves, major vessels and the trachea. Surgical resection was complete where possible, with preservation of vital structures. There were no deaths. Morbidity was confined to wound infection and haematoma, respiratory distress and in one case, a facial palsy. Eight patients required two or more operations for complete excision.

Child, Preschool↗
PubMed1981

Adenomyoma of the pylorus presenting as intestinal obstruction with pseudomyxoma peritonei--a case report.

Adenomyoma of the stomach is an exceedingly rare and benign tumour. We report here what we believe to be the first documented case in Singapore. Our patient is unique in three respects; an eight-week old infant presented with signs and symptoms of intestinal obstruction. Operative findings showed a small tumour in the pylorus of the stomach. The abdominal contents were covered with a colourless mucous slime, giving an appearance of pseudomyxoma peritonei. This is a feature which has not been hitherto reported. Microscopically, the lesion was consistent with adenomyoma of the pylorus. The interesting feature is an abundant production of mucin, with rupture and spillage of mucin in some of the glandular structures. We believe that this may account for the appearance of a pseudomyxoma peritonei seen in our patient.

Diagnosis, Differential↗