Biomedical subjects
Publications and source records attributed to V Sudha.
A 55 year old female presented with fever, skin rash and subconjunctival hemorrhage. She also developed hepatitis. Fever and skin rash lasted for more than three weeks. This patient was diagnosed to have rubella, highlighting the fact that rubella can present with atypical features like prolonged fever and rash, subconjunctival hemorrhage and hepatitis, especially in adults.
OBJECTIVE AND STUDY DESIGN: A nonrandomized open labeled clinical trial to evaluate the efficacy and tolerability of Dianex (a poly herbal formulation developed by Apex Laboratories [PVT] Chennai, Tamil Nadu, India) in type 2 diabetes mellitus was carried out during a 6-month period. SETTING/LOCATION: This study was conducted in TMA Pai Hospital, Udupi, South India. SUBJECTS: A total of 40 patients were recruited for this study. Three patients dropped out of the study leaving a total of 37 patients (11 for monotherapy and 26 for add on therapy). OUTCOME MEASURES: Eighteen (18) clinical variables were investigated, including liver enzymes, kidney function tests, hematologic parameters, blood glucose, and insulin and lipid profiles. RESULTS: at the end of 12 weeks it was found that there was a significant decrease in the level of glycated hemoglobin, fasting plasma insulin level, insulin resistance, and systolic and diastolic blood pressure. At the end of 24 weeks results were similar to those at 12 weeks. Dianex did not alter the liver function tests, hematological parameters, or kidney function tests. CONCLUSION: In this preliminary study, Dainex is found to be an effective adjuvant drug with either oral antidiabetic agents or insulin that can be used in the control of blood sugars in diabetic patients. Dianex is a safe drug that does not cause any clinical, hematological or biochemical alteration in major organ systems.
Tropical pyomyositis is a primary pyogenic infection of skeletal muscle, often caused by Staphylococcus aureus. The most common presentation of tropical pyomyositis is that of multiple acute abscesses with fever. Hepatitis is a rare manifestation of this disease. We report a case of tropical pyomyositis who presented with hepatic encephalopathy leading to initial diagnostic dilemma.
A novel simulation procedure for estimating the dehydration energies of NaCl solutions spanning a wide range of concentrations, which incorporates ionic and molecular sizes, ion-pair formation, etc., is proposed on geometric and phenomenological considerations. The extent of dehydration during each movement of the hydrated molecule is evaluated using the expected and actual displacement of the species and mean nearest-neighbor distances. The interdependence between the size of the simulation box, number of molecules, and electrolyte concentration is pointed out.
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A diabetic patient with a non-healing leg ulcer was found to be allergic to both conventional insulin and purified monocomponent insulin of porcine origin. He was successfully treated with human insulin.
We report on the reproducibility and validity of a food frequency questionnaire (FFQ) developed for southern India. One hundred and two adult subjects aged > or =20 years drawn from the Chennai Urban Rural Epidemiology Study participated. The FFQ was developed based on local foods and habits, and was administered three times at 0, 6 and 12 month periods (called FFQ1, FFQ2 and FFQ3) to assess the reproducibility. To test the validity of the FFQ, multiple 24-h recalls collected at 2-monthly intervals for a period of 1 year and the estimated energy intake/basal metabolic rate (EI/BMR) ratio were used. The 'EpiNu' in-house food and nutrient database was used to compile dietary intakes, which were analyzed for statistical analysis. The intraclass correlation coefficient for all three FFQs ranged from 0.72 for carbohydrates to 0.45 for folate. The de-attenuated Pearson correlation for the energy adjusted nutrients between FFQ3 and 24-h recalls ranged from 0.73 for carbohydrates to 0.35 for calcium. Bland and Altman plots for energy intake between the two methods showed the limits of agreement ranged from 768 to -1358 calories/day (+/-2 standard deviations). Misclassification was low for most of the nutrients. Under-reporting of the energy intake (EI/BMR ratio<1.2) was higher in females than males. This FFQ appears to be a robust tool to measure dietary intakes in southern India.