Biomedical subjects

V Stojanović

Publications and source records attributed to V Stojanović.

At least 19 recordsLinked to original sources

PubMed2005

The prevalence of Shiga toxin-producing Escherichia coli in domestic animals and food in Serbia.

Faecal samples of 2660 domestic animals from 116 farms and 956 samples of food were examined for the presence of Shiga toxin-producing Escherichia coli (STEC). STEC was recovered from 126 (15.3%) cattle, 135 (11.3%) pigs, 135 (66.8%) sheep, 31 (73.8%) goats, 4 (1%) chicken, and 15 (1.6%) food samples. Of all STEC isolates, 21.5, 25.8 and 15% produced enterohaemolysin, alpha-haemolysin, and aerobactin respectively, 1.6% displayed localized adherence (LA) to HEp-2 cells, 27.6% were sorbitol negative, and 30% were resistant to antibiotics. Only 14 (3.1%) of the STEC isolates belonged to human infection-associated serogroups (O26, O55, O111, O128 and 0157), designated as enterohaemorrhagic E. coil (EHEC). This study revealed that STEC are prevalent in domestic animals, and to a lesser extent in food of animal origin in Serbia, but the absence of a EHEC phenotypic profile (characteristic serogroup, LA, enterohaemolysin production) in most animal STEC strains may explain the low incidence of human STEC infection in this part of the world.

Animals↗

PubMed1991

Beta 2-microglobulinuria in a population exposed to Balkan endemic nephropathy: inferences from repeated cross-sectional studies.

Baseline data from a study run in 1974, which comprised beta 2-microglobulinuria (beta 2mu) measurements at monthly intervals from 416 members in 112 households from the BEN affected village of Petka, were compared with the results of two subsequent, cross sectional studies. In June 1988, retesting involved 320 available persons from the same households. Another collection of 284 urine specimens took place in October 1989. Prevalence of tubular proteinuria was the same in 1988 and 1989 as it was in 1974, indicating that the level of exposure to nephrotoxic agent did not change over time. Over 94% of the individuals who were always beta 2mu negative in 1974 remained negative in 1988. By contrast, over two thirds (68.7%) of those who were positive two or more times 14 years ago, tested positive upon re-examination in 1988. Particular interest arises from the data on those initially repeatedly positive persons in whom the overt disease did not occur over time; moreover, some appeared to be unaffected in 1988 and 1989 according to our set of laboratory criteria. The results suggest occasional slow progression and even possible reversibility of tubular lesions in individuals living in the BEN affected environment.

Adult↗

PubMed1987

The effect of enkephalins and of beta-endorphin on the hypertensive response to physostigmine in the rat.

1 Intracarotid injection of [Leu]enkephalin and [Met]enkephalin produced a dose-dependent biphasic change in blood pressure of the rat consisting of an initial shortlasting fall followed by a longlasting increase of blood pressure. Naloxone consistently depressed or abolished the effects of enkephalins on blood pressure. 2 Intracarotid injection of beta-endorphin only occasionally produced a hypotension, or did not produce any change in the blood pressure of the rat. 3 All three opioids ([Leu]enkephalin, [Met]enkephalin and beta-endorphin) significantly depressed or abolished the hypertensive response to intravenous injection of physostigmine. This depressive action of opioids was easily reversed by naloxone. 5 It is concluded that opioids depress the central cholinergic link implicated in the hypertensive response to physostigmine most probably by inhibiting acetylcholine and/or noradrenaline release in the structures relevant for the action of physostigmine on blood pressure of the rat. This interaction is realized through the activation of opioid receptor(s).

Animals↗

PubMed1983

[Endotoxic shock in surgical practice].

The authors present patients who have had an endotoxic shock from various types of septic infections in the peritoneal cavity (ulcus perforatum, appendicitis perforata, cholecystitis purulenta, acute obstruction of the intestine, pleural empyema, bronchiectasiae, pulmonary abscess etc.). The author's intention is to indicate that the etiological factors can be different, and the pathophysiological and clinical treatment have certain specific characteristics. The basic pathophysiological postulates are: severe haemodynamic disorders and numerous functional troubles and disorders of certain organs and tissue's systems. Thereby, the therapy should always be casual as well as one slows down the haemodynamic and other pathophysiological disorders.

Humans↗

PubMed1982

[Dilemmas related to expectant or acute stages in closed injuries of the thorax and abdomen].

Non penetrating injuries of thorax, abdomen and thoraco-abdominal injuries, following its etiology, pathogenesis, and pathoanatomical substrate are also with consequent clinical manifestations, very complicated diagnostico-therapeutical problem. The surgeon is often i dilemma, which the therapy will be the most adequate for the patient and the time for the decision is usually short. In the report, various types of nonpenetrating injuries are analysed, and relating to its nature and the grade of severity, the proper therapy is discussed. We suppose that in situations like that, along with numerous tests, the explorations should be used and applied in doubtful cases, so it can only enables right diagnosis and in such way adequate therapy in the period of the time the surgeon can count on.

Abdominal Injuries↗

PubMed1980

Some experimental aspects of using lungs as biological oxygenator in extracorporal circulation.

Exposing problem of oxygenators in extracorporal circulation authors consider screen and membrane as the best, in spite of some disadvantages from which the haemolysis is the most cumbersome. In attempt to find the way of solution of this problem, authors have made a number of experiments in animals where they have conducted extracorporal circulation in such way that blood has been oxygenated in own lungs of an animals. Two types of bypass were examined as: right to right bypass (vv. cavae-pulmonary artery), right to right bypass as exposed with possibility of interconnection with classical extracorporal circulation, and finally bypass of the left and right heart. Exposing their experience and results authors consider that use of lungs as biological oxygenator in extracorporal circulation has its justification according to achieved results. In spite of some problems which need further elaboration such experiments are the motive for more work and reflexion in this type of problem.

Animals↗

PubMed1978