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Biomedical subjects

V Srinivasan

Publications and source records attributed to V Srinivasan.

At least 55 records · Page 3Linked to original sources
PubMed2001

Growth of AM fungi on in vitro root organ culture of Sorghum vulgare and Saccharum officinarum.

Spores of Gl mosseae and Gig gigantea germinated on minimal medium produced extraradical mycelium. Gl. mosseae infected roots of S. officinarum in in vitro condition were inoculated in M medium with in vitro cultured roots of Sorghum vulgare (test roots). From the infected root of S. officinarum, the mycelium developed and it infected the test roots. The roots developed new mycelia and further the mycelia produced a few hyaline spores. In MS medium combined with soil extract, root exudate, thiamine HCl and inositol combination, spore germination and germ tube growth were higher when compared with other media.

Culture Techniques↗
PubMed2000

Pars tensa retraction pockets in children: treatment by excision and ventilation tube insertion.

Tympanic membrane retraction pockets involving the pars tensa are not uncommon in clinical practice. Recurrent infections, ossicular erosion and cholesteatoma are the recognized sequelae. The management options include surveillance, medical treatment and surgery. The surgical procedures range from grommet insertion to extensive tympanoplasty procedures. We report our experience with simple excision and grommet insertion, performed in 31 ears in 26 patients as day cases. The follow-up ranged from 8 to 34 months with a mean of 16 months. The procedure was successful in 23 ears (success rate of 74%). Recurrence of retraction occurred in seven ears and in one ear there was a persistent perforation. Age, previous grommet insertion and severity of retraction did not have a statistically significant influence on the final outcome. We conclude that excision and grommet insertion is a simple, safe and efficient procedure for the management of tympanic membrane retraction pockets and can be considered in preference to extensive tympanoplasty.

Adolescent↗
PubMed2000

Surgical management of intractable epistaxis: audit of results.

We have audited our results after changing the management practice in patients with intractable epistaxis. These patients are offered trans-nasal endoscopic sphenopalatine artery diathermy with or without anterior ethmoid artery diathermy instead of conventional surgical procedures. During the first year after the change in practice, 145 patients were treated as inpatients for epistaxis. Ten patients (seven per cent) required a surgical procedure under general anaesthesia due to the recurrent nature of bleeding. All 10 patients had endoscopic sphenopalatine artery diathermy, whereas in four patients anterior ethmoid artery diathermy was also performed concurrently. The post-operative hospital stay ranged from one to three days (mean 2.1 days). The mean follow-up was 10 months. The epistaxis recurred in one patient and this was managed conservatively. There were no complications related to surgery. In the previous year, 132 patients were admitted for epistaxis and eight patients had surgical procedures, which included septoplasty, nasal packing and external carotid artery ligation. The post-operative stay ranged from three to six days (mean 3.9 days). Our audit shows that endoscopic sphenopalatine artery diathermy is a safe, successful and effective management option for patients with refractory epistaxis. The morbidity is reduced and the hospital stay is shortened. The sphenopalatine artery diathermy can be combined with anterior ethmoid surgery, when necessary.

Aged↗
PubMed1999

Sphenoid sinus schwannoma treated by endoscopic excision.

Schwannomas, arising from the Schwann cells of the nerve sheath, occur very rarely in the sino-nasal tract and histological diagnosis can, sometimes, be difficult. We describe a case of schwannoma of the sphenoidal sinus occurring in a 71-year-old man, who underwent complete excision of the tumour endoscopically. To our knowledge, this is the third case of sphenoid sinus schwannoma reported in the English literature.

Aged↗
PubMed1998

Use of a disposable electrode for recurrent laryngeal nerve monitoring.

Our experience with a non-invasive, disposable electrode for intra-operative identification and monitoring of the recurrent laryngeal nerve is described. The electrode system, while simply attached to the endotracheal tube, acts as a laryngeal surface electrode and detects electromyographic activity of the intrinsic laryngeal muscles when the recurrent laryngeal nerve is stimulated. We have successfully used this electrode to monitor 19 recurrent laryngeal nerves in 15 patients who have undergone partial or total thyroidectomy. We feel that this device can be useful particularly in cases of re-exploration and malignancies of the thyroid gland.

Disposable Equipment↗
PubMed1998

An unusual presentation of a nasal septal abscess.

Nasal septal abscess is a rare complication of septal haematoma. Nasal obstruction and, less frequently, pain are the usual presenting features. We report a case of a nasal septal abscess in a 21-year-old female patient who developed a naso-oral fistula. To our knowledge this is the first report of such an unusual presentation of a septal abscess. The aetiology, pathogenesis and management of septal abscesses are discussed.

Abscess↗
PubMed1998

Differences in active avoidance behaviour of hypoactive and hyperactive rats subjected to immobilisation stress.

Open field activity was studied in Wistar rats. Animals with low scores of ambulatory and rearing behaviours were grouped as hypoactive and those with high scores as hyperactive. Acquisition of active avoidance learning in a shuttle box was studied in the two groups. Hyperactive rats in contrast to hypoactive rats showed a better acquisition of avoidance learning. Learning was suppressed in both groups by domperidone, but was facilitated by immobilisation stress in the hypoactive group only. The two groups did not differ in the basal and stress evoked heart rates. These observations suggest that immobilisation stress favours enhancement of the dopaminergic related behaviour like avoidance learning in hypoactive rats.

Animals↗
PubMed1997

Transtympanic myringoplasty in children.

Our experience with myringoplasty by the transtympanic "push through' technique in paediatric patients is described. We have used this method in 40 children utilizing autologous temporalis fascia as the graft material. The procedures were all performed as day cases under general anaesthesia. The overall success rate for perforation closure was 77.5% at 6 months which is comparable to conventional methods. We conclude that the "push-through' technique is a safe, simple, reliable and cost-effective procedure that can be performed as a day case in paediatric patients. It avoids the necessity for pressure bandaging or formal ear packing. To our knowledge this is the first paper evaluating this technique in children.

Adolescent↗
PubMed1997

Analgesic effects of codeine-6-glucuronide after intravenous administration.

Centrally administered codeine glucuronide has been shown to exhibit antinociceptive properties with decreased immunosuppressive effects compared to codeine. In this study, codeine-6-glucuronide was administered to rats, and its analgesic effect was compared to that of codeine. The concentrations of codeine and its metabolites in plasma and brain were also determined at the peak response time after administration of each compound. Receptor-binding studies with rat brain homogenates and affinity profiles were also determined. Intravenous administration of codeine-6-glucuronide resulted in approximately 60% of the analgesic response elicited by codeine itself. Analysis of plasma and brain showed that codeine-6-glucuronide is relatively stable in vivo, with only small amounts of morphine-6-glucuronide being detected in addition to unchanged codeine-6-glucuronide. The receptor affinity of codeine-6-glucuronide was similar to that of codeine. It is concluded that intravenously administered codeine-6-glucuronide possesses analgesic activity similar to that of codeine, and may have clinical benefit in the treatment of pain

Journal Article↗
PubMed1997

Melatonin, biological rhythm disorders and phototherapy.

Biological rhythms are endogenous in nature and are generated by self sustained oscillators present in the living organisms themselves. Of these, circadian rhythms are the most thoroughly studied and are driven by the suprachiasmatic (SCN) of hypothalamus. The recent discovery of high affinity melatonin receptors ML1, ML2 in SCN suggests that melatonin is involved in the control of circadian rhythm generation. The fact that biological rhythm disorders like delayed sleep phase syndrome (DSPS), Jet lag, shift-work disorders, seasonal effective disorder (SAD) respond well either to phototherapy or melatonin adds further support to the concept that melatonin is involved in the pathogenesis of these conditions. Indeed altered melatonin rhythms have bee documented in MDP, shift work disorder, endogenous depression etc. In addition to functioning as a rhythm regulator, melatonin is also involved in the control of sleep, regulation of body temperature, reproduction, and as a free radical scavanger and antioxidant protecting the cells and tissues of our body against oxidative damage. Low levels of melatonin in cancer patients and patients with coronary heart disease indicate that melatonin may be involved in these disorders also.

Body Fluids↗
PubMed1997

Warfarin and epistaxis: should warfarin always be discontinued?

The object of this study was to determine whether warfarin could be safely continued in patients with epistaxis if the International Normalized Ratio (INR) was within the suggested therapeutic range. Twenty patients on warfarin treatment were compared with controls, matched for age and sex. Local measures for the control of epistaxis were undertaken appropriately in all the patients. In the warfarin group 17 patients (85%) did not discontinue warfarin as the INR was within the suggested range. There were no additional bleeding complications or failure of epistaxis control due to continuation of warfarin. There was no significant difference in the mean hospital stay between the warfarin and non-warfarin groups. It is concluded that warfarin can be continued safely in patients with epistaxis, in appropriate circumstances, and that the policy of stopping warfarin routinely in all patients with epistaxis should be reconsidered.

Aged↗