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Biomedical subjects

V Salmon-Ehr

Publications and source records attributed to V Salmon-Ehr.

At least 19 recordsLinked to original sources
PubMed1999

[Secondary longitudinal melanonychia secondary to onychophagia].

BACKGROUND: Melanonychia of the toenails sometimes results from repeated trauma. This etiology is rarely put forward in lesions affecting the fingernails. CASE REPORT: A 44-year-old woman developed melanonychia affecting 9 fingernails. Genetic predisposition and drug, hormonal or infectious causes were ruled out and we postulated that the lesions were induced by nail biting. DISCUSSION: Nail biting is known to lead to several types of lesions, including melanonychia. The lesions may sometimes disappear several months after stopping this habit.

Adult↗
PubMed1998

A comparative study of cryogenic lesions in organ-cultured human skin and in reconstituted human skin equivalent.

Cryosurgery is a technique that is widely used in the treatment of cutaneous tumors. However, there are still features of healing in cryosurgery wounds that are incompletely understood and necessitate further study. In the present paper, we describe two in vitro models that were developed to study the initial stages of development of the cryolesion: reconstituted human skin and organ-cultured human skin. Cryolesions were generated in both models by applying a 2-mm-diameter cryoprobe at -196 degrees C for 35 s. Histological features were analyzed at days 0, 3, 5, and 14 following cryotreatment and showed epidermal detachment and keratinocyte necrosis very close to the findings reported in vivo. Results were similar in the two models. Gross alteration of the dermal architecture was noticed beneath the cryolesion, particularly in the reconstituted skin model. Cell proliferation was investigated at days 0, 3, and 5 by [3H]thymidine incorporation and Ki-67 antigen immunolabeling. In the case of organ-cultured skin, a significant increase in keratinocyte and fibroblast proliferation was observed at day 3, compared to the controls. At day 5, a return to the basic level was noticed. This was not observed in the reconstituted skin model at either day 3 or day 5. These data led us to propose that organ-cultured skin may be a useful model for evaluating the response of human skin to freezing; reconstituted skin was not adequate for this purpose.

Cryosurgery↗
PubMed1998

[Multiple isolated cutaneous myxomas].

INTRODUCTION: Cutaneous myxomas are rare. They are more often single; when they are multiple, they may be one of the component of the Carney's syndrome. CASE REPORT: We report a case of multiple and isolated cutaneous myxomas arising at 19 year-old. Diagnosis was confirmed by histologic studies. Examination failed to reveal other cutaneous or visceral features. DISCUSSION: The multiplicity of cutaneous myxomas is an essential element for diagnosis of Carney's syndrome; other components and notably atrial myxomas can appeared over time. Normal visceral explorations don't eliminated the diagnosis, and follow-up including screening echocardiography must be ensured before concluding, as in our case, as multiple and isolated cutaneous myxomas.

Adult↗
PubMed1998

[Chronic depigmentation due to positive patch tests for methacryate derivatives].

INTRODUCTION: Many chemical products are known to induce depigmentation. This phenomenon was never reported with methacrylates which are components of acrylic resine. CASE REPORT: A female patient with artificial nails developed contact dermatitis. Localized depigmentation at the site of positive patch tests to methacrylates derivatives was observed. DISCUSSION: The chemical substance could have a direct influence either by its toxic effect or by the induced inflammatory reaction.

Adult↗
PubMed1997

Antagonistic effects of interferon-gamma and interleukin-4 on fibroblast cultures.

A major characteristic of scleroderma (SSc) fibroblasts is an increased biosynthesis of extracellular matrix macromolecules that could be linked to impaired regulation by cytokines. We investigated the effects of two cytokines from T lymphocytes, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma), on normal and scleroderma fibroblast cultures. In both types of fibroblasts, IL-4 strongly stimulated collagen synthesis, whereas IFN-gamma was a potent inhibitor. The effects of these cytokines were localized at the pre-translational level, and both mRNA steady-state level and protein synthesis were equally affected. SSc fibroblasts responded to IL-4 and IFN-gamma as well as normal fibroblasts. When fibroblasts were incubated with combinations of both cytokines, IFN-gamma completely suppressed the stimulation of collagen gene expression induced by IL-4. Northern blot and western blot analyses demonstrated that IFN-gamma induced a rapid and strong decrease in the expression of the IL-4 receptor-alpha by fibroblasts. This effect might explain the antagonistic effects of IFN-gamma on the IL-4-dependent enhancement of collagen synthesis. Thus, our data suggest that the alteration of collagen production in scleroderma fibroblasts does not depend on an altered sensitivity of these cells to stimulatory or inhibitory cytokines but is more likely the consequence of an imbalance in the local production of autocrine or paracrine regulatory factors.

Cell Division↗
PubMed1997

[Palmoplantar filiform parakeratotic hyperkeratosis and digestive adenocarcinoma].

INTRODUCTION: There are very few observations of filiform palmo-plantar hyperkeratosis reported. Nevertheless it's worth knowing this entity for his potential association with a visceral neoplasia. CASE REPORT: We report the first case of filiform palmo-plantar hyperkeratosis associated with a digestive adenocarcinoma and a polycystic kidney disease. DISCUSSION: After a review of palmar and plantar filiform hyperkeratosis in the literature, we will discuss the possible association with neoplasia or other pathologies. This pathology requires a strict clinical and paraclinical follow-up.

Adenocarcinoma↗
PubMed1996

[Unilateral gustatory flushing syndrome in a child].

BACKGROUND: Auriculo-temporal syndrome is rarely seen in children: it is sometimes considered as secondary to an obstetrical injury. CASE REPORT: A 2.5 year-old boy was examined because he suffered from post-prandial flushing of the right cheek for 2 years. He was born normally and neurologic examination was normal. The rash was not associated with sweating or tearing. CONCLUSION: There is no evidence to support food allergy in this case: rather, this syndrome probably occurs in response to salivation.

Child, Preschool↗
PubMed1996

Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis.

BACKGROUND: Scleroderma (systemic sclerosis) is a fibrotic disease characterized by an uncontrolled tissular accumulation of collagen. Several cytokines have been implicated in the fibroblast activation leading to fibrosis. For instance, we have previously demonstrated that interleukin-4 (IL-4) is a potent activator of collagen synthesis in fibroblast cultures. In this study, using immunocytochemical methods and in situ hybridization, we investigated the expression of IL-4 in normal and scleroderma skin and fibroblast cultures. OBSERVATIONS: Immunocytochemical studies with anti-IL-4 antibody were performed on biopsy specimens from 9 patients with normal skin and 11 patients with scleroderma. The label was intense or strong in 8 of the 11 scleroderma skin specimens, whereas it was negative or faint in 8 of the 9 normal skin specimens (P < .01). In situ hybridization demonstrated a significant increase of the number of IL-4 messenger RNA grains in scleroderma skin compared with normal skin (3.1 +/- 1.5 [mean +/- SD] vs 0.8 +/- 0.7; P < .001). A strongly positive labeling with the anti-IL-4 antibody was found in the 4 scleroderma fibroblast cultures, whereas it was negative in the 5 fibroblast control cultures (P < .05). CONCLUSIONS: Our results demonstrate that IL-4 is strongly expressed in the dermis of a large majority of patients with scleroderma and might be synthesized by scleroderma fibroblasts. We suggest that IL-4 is one of the cytokines implicated in the early steps of the fibrotic process.

Adult↗
PubMed1996

[Vulvar lymphangiectasis 14 years after treatment for epidermoid carcinoma of the cervix. Treatment with cryosurgery].

INTRODUCTION: Lymphangiectasia are different from lymphangioma because they arise following damage to the deeper lymphatic vessels. No clinical or histological features are known to distinguish lymphangioma from lymphangiectasia. CASE REPORT: We report a case of vulvar lymphangiectasia occurring 14 years after therapy of squamous carcinoma of the cervix (surgery and post-operative radiotherapy). Our treatment was cryosurgery. DISCUSSION: We analysed the 12 case reports of vulvar lymphangiectasia in the literature, emphasizing misleading clinical aspect of the warty lesions and the risk of repeated infection justifying an appropriate treatment. We propose cryosurgery which provides real benefits with a minimal trauma.

Carcinoma, Squamous Cell↗
PubMed1996

[Cutaneous metastases of melanoma localized on the cicatrix at the site of flap taking].

INTRODUCTION: We report one case of melanoma cutaneous metastases strictly localized on a skin graft donor site distant from the tumor site. CASE REPORT: A patient with a shoulder melanoma was treated by surgery. A split-thickness skin graft was taken from a thigh to cover the raw area. Six months later, nodular cutaneous metastases strictly localized on the skin graft donor site appeared. COMMENTS: Physiopathology of those lesions is unknown. Hyaluronic acid is increased in granulation tissue and could be chimiotactic for melanoma cells.

Aged↗
PubMed1995

[Acute febrile pustular and bullous neutrophilic dermatosis (Sweet syndrome) disclosing acute myeloblastic leukemia].

We report a patient with Sweet's syndrome (acute febrile neutrophilic dermatosis) revealing an acute myelogenous leukemia. About 10% of Sweet's syndromes are associated with a malignant disease that they can reveal. Among those, hemopathies are the most frequent, and 42% are myelogenous leukemia. These observations emphasize the particular clinical aspects of the Sweet's syndrome associated with an hemopathy.

Adult↗
PubMed1994

[Interleukin-4: from B-lymphocyte to fibroblast].

Interleukin-4 (IL-4) has been characterized in 1982 by its ability to induce the proliferation of anti-IgM stimulated B-lymphocytes and IgG1 secretion by these same cells after activation by lipopolysaccharide. It's activity on B-cells explain that it received the former names of B-Cell Growth Factor-1 (BCGF-1) or B-Cell Stimulatory Factor-1 (BSF-1). More recent works have shown that IL-4 exerts pleiotropic effects on a large number of cells. Particularly, it is able to activate the production of extracellular matrix components by fibroblasts. The aim of the present paper is to review main data about this cytokine, with a particular emphasis on its role on the regulation of connective tissue cell activities and on its possible implication in pathophysiological events such as fibrosis, wound healing, and tumor invasion.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Recurrent painful hand crisis in a four-year-old girl, revealing an erythropoietic protoporphyria.

We report the case of a 4-year-old girl, who had been suffering for 2 years from a recurrent, painful crisis affecting both hands, following sun exposure. There were no obvious cutaneous lesions, which initially caused us to consider a diagnosis of a psychiatric disorder. However, the diagnosis of erythropoietic protoporphyria was then established by the demonstration of elevated levels of free protoporphyrin in erythrocytes. The present case illustrates the effectiveness of beta-carotene associated with canthaxanthin in erythropoietic protoporphyria.

Antioxidants↗