Biomedical subjects

V Sahgal

Publications and source records attributed to V Sahgal.

68 records · Page 4Linked to original sources

PubMed1978

Residual latency: new applications of an old technique.

Median and ulnar nerve conduction velocity was studied using residual latency techniques in a control population and in a population with neuropathy. Midpalmar stimulation sites were used to determine the residual latency of the distal short segment. The residual latency index (RLI) was the short segment residual latency divided by the residual latency for the entire terminal nerve segment. While it was 0.61 in the control population, it increased to 0.69 in the patients with ulnar neuropathy distal to the wrist and decreased to 0.36 in patients with neuropathy of the median nerve at the carpal tunnel. In five cases of median neuropathy at the carpal tunnel, muscle biopsy specimens revealed evidence consistent with neuropathic processes. The RLI is an accurate and relevant method of evaluating the sensory and motor conduction of very small nerve segments.

Adolescent↗

PubMed1977

Department of Neurology, Northwestern University Medical School, Chicago, Illinois.

A case of non-progressive congenital myopathy is described in which there was absence of muscles and scapulo-peroneal distribution of weakness. The muscle biopsy showed preferential atrophy of Type I fibers and subsarcolemal bodies. These bodies were composed of an acidic protein with sulphahydryl groups which showed acid stable adenosine triphosphatase activity. The possibility of a maturational arrest as a cause is presented.

Adenosine Triphosphatases↗

PubMed1977

Neurotransmitters in spinal cord injury.

The authors report the distribution of acetylcholinesterase activity and catecholamine fluorescence in the intact and completely transected rat spinal cord. The catecholamine terminals were scarce in the posterior horn and abundant in the intermediale and anterior horn regions. In the thoracic region, intense amine fluorescence was seen in the intermediolateral cell column. Spinal transection resulted in the enhancement of fluorescence above the lesion and disappearance below the lesion within seven days. The cholinesterase activity in the controls was found mostly in the anterior horn region and the tip of the posterior horn. Following transection, there was no significant change in the distribution of this enzyme. These changes correlated with the appearance of spasticity.

Acetylcholinesterase↗

PubMed1977

Histochemical and morphologic changes in skeletal muscle following cervical cord injury: a study of upper and lower motor neuron lesions.

The effects of upper and lower motor neuron lesions on human skeletal muscles and muscle spindles were studied using histochemical and morphometric techniques. In the lower motor neuron lesions, the muscle fibers showed group atrophy, fiber type grouping and target fibers. The muscle spindle demonstrated thickening of the capsule, degeneration of the nuclear chain fibers, targeting and splitting of the bag fibers. In the upper motor neuron lesion, the muscles showed group atrophy with histochemical evidence of preferential type II fiber involvement. Histometrics, however, failed to demonstrate type II fiber atrophy but showed hypertrophy of type I fibers. The muscle spindles only showed increased number of intrafusal fibers.

Adenosine Triphosphatases↗

PubMed1976

Histochemical and morphological changes in human muscle spindle in upper and lower motor neuron lesions.

The human intrafusal fibers were found to consist of two morphological and three histochemical (ATPase reaction) types. Two types of nuclear bag fibers were seen. Type A showed alkali stable and acid labile and Type B showed acid and alkali stable ATPase reaction. The nuclear chain fibers showed only alkali stable ATPase reaction. In the lower motor neuron atrophy, muscle spindle showed thickening of the capsule, atrophy of the nuclear chain fibers, and splitting of the nuclear bag fibers. ATPase reaction showed targetoid Type B nuclear bag fibers and 2 types of nuclear chain fibers. Oxidative enzymes also showed targetoid nuclear bag and chain fibers. In upper motor neuron atrophy the spindle showed no changes.

Adenosine Triphosphatases↗

PubMed1975

Heredopathia atactica polyneuritiformis (phytanic acid storage disease). A new case with special reference to dietary treatment.

A 33-year-old man with Refsum disease exhibited clinical features of night blindness, dysequilibrium, hearing loss, itchy dry skin, symmetrical polyneuropathy, distal muscle weakness, pes cavus, and hammer toe. His total serum protein was increased, nerve conduction velocities were slow, and serum phytanic acid levels were high. Dietary restriction of phytol resulted in a decrease in serum phytanic acid without any visual and autitory changes; however, coordination, skin lesions, and nerve conduction velocities definitely improved.

Adult↗

PubMed1972