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Biomedical subjects

V S Li

Publications and source records attributed to V S Li.

22 records · Page 2Linked to original sources
PubMedDate not supplied

[Lipid composition and structure-functional properties of membranes of erythrocytes of different ages].

Age-dependent alterations of plasmatic membranes were studied in rabbit erythrocytes after separation of erythrocytes of various age by means of centrifugation. The membrane structure characteristics were studied using a fluorescent probe pyrene and spin-labelled probes--nitroxyl derivatives of stearic acid and carboline derivatives. Microviscosity of the membrane lipid phase was shown to increase depending on the cell age. Alterations in the membrane structure were accompanied by a decrease in activity of Na-, K+-ATPase. The content and ratio of membrane lipids were altered with an increase in the cell age, which could be one of reasons of the membrane microviscosity elevation. The age-dependent alterations in erythrocyte membranes may be related, firstly, to the mechanism of old erythrocyte elimination from circulation and, secondly, to be the common characteristic for cell ageing, according to the "membrane hypothesis" of ageing.

Animals↗
PubMedDate not supplied

[The effect of covalently and noncovalently bound complexes of albumin with bilirubin on DNA and protein synthesis in liver and spleen of rats subjected to splenectomy and partial hepatectomy].

Noncovalently bound complexes of albumin and bilirubin were found to stimulate DNA and protein synthesis in partially hepatectomized regenerating rat liver tissue, while the covalently bound complex inhibited both these synthesis types in liver tissue after partial hepatectomy. Splenectomy of intact rats caused an induction of DNA and protein synthesis in liver tissue but partial hepatectomy decreased drastically the synthesis rate in spleen, thus suggesting that humoral factors stimulating the proliferation response in liver and spleen tissues were developed after spleen- and hepatectomies. The covalently bound albumin and bilirubin complex did not affect the rate of DNA and protein synthesis in liver tissue of splenectomized rats, while the complex with noncovalent bonds restored the rate of DNA and protein synthesis in the spleen of rats with partial hepatectomy. Only the noncovalently bound complex of albumin and bilirubin exhibited the properties inherent in hepatotropic growing factor whereas albumin administration was not effective. Possible structure and action of the noncovalently bound albumin and bilirubin complex are discussed.

Animals↗