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Biomedical subjects

V S Chadda

Publications and source records attributed to V S Chadda.

At least 19 recordsLinked to original sources

Value of clinico-psychiatric assessment in the diagnosis of chronic intractable pain in abdomen.

To evaluate the role of psychiatric illness in patients with chronic abdominal pain, 50 patients with this symptom were subjected to thorough clinical examination, detailed investigations and Goldberg's 60-item General Health Questionnaire. Those scoring 12 in this questionnaire were subjected to a detailed psychiatric evaluation. Sixteen (32%) patients had pure organic illnesses, 8 (16%) had organic illness with associated psychiatric factors and 26 (52%) had definite psychiatric illness. We conclude that chronic abdominal pain is often associated with psychiatric illness.

Abdominal Pain

Role of QT interval at onset of acute myocardial infarction in predicting early phase ventricular arrhythmia.

In this study, the QTc interval was determined in 51 patients of acute myocardial infarction and the incidence of ventricular arrhythmias in them was noted. It was found that the QTc interval was prolonged (more than 0.44 sec) in all the 33 patients who developed ventricular arrhythmias, while it was below 0.44 sec in all the 18 patients who did not develop ventricular arrhythmia.

Adult

Coronary-prone behaviour pattern and myocardial infarction.

Seventy five patients with acute myocardial infarction (MI) and forty matched control subjects were assessed for coronary-prone behaviour pattern by a self administered scale. Analysis of the results showed a higher incidence (P < 0.001) of type A behaviour pattern in acute (MI) patients, as compared to controls.

Humans

An epidemiologic study of intermittent acute porphyria in Maheshwari community of Napasar, Bikaner (Rajasthan)

An epidemiologic study of intermittent acute porphyria in the Maheshwari community of Napasar, Bikaner (Rajasthan) was conducted. Twelve cases were detected among 1900 persons belonging to ten families surveyed (prevalence 1:408). The disease was more common in females and the maximum number (4 cases) was encountered in the age group 21-30 years. The disease was more common in Mundhra (4 cases) and Mohata (3 cases) subcastes.

Acute Disease

Portal hypertension therapy with oral propranolol. A short-term study.

Thirty patients were evaluated in a blind fashion to study the effect of oral propranolol on portal hypertension of varied aetiology. The dose of oral propranolol (administered to 15 patients) was adjusted to reduce the resting heart rate by approximately 25%. Splenic pulp pressure served as the parameter for portal pressure. A matched group of 15 control subjects on placebo was also studied. The mean portal pressure in the propranolol group fell from 3.49 to 2.69 kPa saline (P less than 0.001) as compared to the control group where the mean pressure increased from 3.57 to 3.63 kPa saline. The propranolol group showed improvement in clinical symptomatology with a significant reduction in body weight and abdominal girth in patients with ascites. A significant positive correlation (r = 0.78; p less than 0.007) was obtained between the fall in portal pressure and the initial levels. Thus, oral propranolol proved useful in the conservative management of portal hypertension of varied aetiology.

Administration, Oral

Comparative value of glutamic oxaloacetic transaminase and lactic dehydrogenase enzyme pattern in serum and cerebrospinal fluid in acute cerebrovascular accidents.

A study of glutamic oxaloacetic transaminase (GOT) and lactic dehydrogenase (LDH) enzymes in serum and cerebrospinal fluid (CSF) was carried out on 30 cases of acute cerebrovascular accident (CVA) to determine their role in precise diagnosis and prognosis of the cases. The CSF GOT and LDH activities were well correlated with the severity, mortality and peak and proper timing in relation to infarct, same is about serum GOT. A characteristic rise of GOT and LDH was observed in cerebral haemorrhage especially in fatal cases. However, in cerebral thrombosis and embolism specially in non-fatal cases, the enzyme change was not so marked. GOT and LDH enzyme pattern in CSF and serum may, therefore, serve as an early, relatively easy and widely available tool for differential diagnosis and prognosis of cases of acute CVA.

Aspartate Aminotransferases

A study of incidence of Australia antigen and derangements in liver function tests in leprosy.

The present study was conducted in 50 patients of various subtypes of leprosy (Lepromatous, Tuberculoid, Borderline borderline) and 25 healthy control, for detection of Australia antigen and various liver function tests (serum protein, cholesterol, alkaline phosphates, SGOT, SGPT, bilirubin and liver biopsy) to see incidence of Australia Antigen and derangement in liver function. It was concluded that incidence of Australia antigen in study and control group was zero. Total serum protein and serum globulin was increased in lepromatous leprosy. A/G ratio was reversed in 34.3% and 50% in lepromatous and tuberculoid leprosy respectively. Granulomatous hepatitis was seen in 66.66% and 50% cases of lepromatous and tuberculoid leprosy respectively. No relationships was established between hepatic lesion, Australia antigen and liver function test.

Adolescent

Dermatomyositis.

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Adolescent

A study of estimation of serum alpha-1-antitrypsin in various forms of leprosy.

Study of serum alpha-1 antitrypsin by agar gel electrophoresis was carried out in 25 patients of various forms of leprosy including 9 cases of Erythema nodosum leprosum, and was compared with findings in 25 healthy controls. The level of serum alpha-1 antitrypsin in healthy subjects ranged from 211 mg% to 602 mg% with a mean level of 290.92 mg% +/- 86.82 mg, have p value 0.1, while in leprosy patients of various types ranged from 129 mg% to 702 mg% with mean level of 405.84 mg% +/- 152.70. Nine patients of lepromatous leprosy with ENL had marked elevation of serum alpha-1 antitrypsin and level was 376 to 720 mg% with a mean level of 562.65% +/- 106.62, statistically significant.

Adult