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Biomedical subjects

V Rippere

Publications and source records attributed to V Rippere.

At least 19 recordsLinked to original sources

Possible steroid withdrawal syndrome following short Synacthen test--a personal report.

Symptoms not attributable either to disease rebound or to adrenal suppression have been reported both in patients receiving steroids when long-term therapy has been stopped and in normal volunteers after single oral doses of prednisolone or intravenous equivalents. This so-called steroid withdrawal syndrome remains poorly understood. It has not previously been reported following exposure to increased levels of endogenous steroids after diagnostic administration of synthetic adrenocorticotrophic hormone (ACTH). The author's personal experience of an apparent steroid withdrawal reaction following a short Synacthen test is described. It is suggested that as yet unidentified individual factors must play a role in determining whether steroid withdrawal symptoms occur. Closer observation of other subjects after the Synacthen test might reveal other instances of steroid withdrawal symptomatology following this common diagnostic procedure.

Cosyntropin

Hypothalamic hypothyroidism with end-organ resistance--further personal observations.

Further personal observations are made of the case of hypothalamic hypothyroidism with end organ resistance described in an earlier report. The course of the disorder on replacement therapy appears to be a relapsing one, with relapses provoked by seasonal changes and physical stresses. The relapses remit with increased doses of thyroid replacement. There is some evidence of increased levels of reverse T3 prior to T3 replacement and also evidence suggestive of a parallel hypothalamic hypoadrenal deficit.

Adrenal Glands

'Psychic sensitivity', mystical experience, head injury and brain pathology.

The 'psychic' experiences of 17 students (sensitives) from the College of Psychic Studies were compared with those of 17 church-going control subjects, who were matched for age, sex, and approximate intellectual level. At interview, 67 items of information relating to the medical history, family history, 'psychic gifts', head injuries, and mystical experiences were obtained. The shortened WAIS, the Benton Visual Retention Test, with tests of both dominant (Wechsler Logical Memory) and non-dominant temporal lobe function (the Rey-Osterreith Test) were given. The results showed that the sensitive population contained more single or divorced people, and people who had sometime consulted a psychiatrist. They had experienced more head injuries and serious illnesses than the controls. Sixty-six per cent showed evidence of right hemisphere and right temporal lobe dysfunction and, of these, 35 per cent had poor visual memories. There was evidence to suggest that some 'psychic' experiences were associated with brain dysfunction. Despite an increased occurrence of head injury, no clear correlation with the onset of 'psychic' sensitivity was found. Mystical experiences showed a trend towards being related to non-dominant hemisphere dysfunction. Vagueness about the position of the sensitive's 'psychic helper' in physical space was also associated with non-dominant hemisphere dysfunction.

Adult