Search PubMed⌕ Search

Biomedical subjects

V Richter

Publications and source records attributed to V Richter.

100 records · Page 6Linked to original sources
PubMedDate not supplied

[Oral fat tolerance test in obese patients].

19 adipose patients, 10 of them women, underwent an oral fat tolerance test with circa 50 g triglycerides. Before the loading test as well as 2 and 4 hours after it the serum lipids were determined. While in the cholesterol components (including the index of arteriosclerosis) no significant shiftings were the result, after 2 hours in the triglycerides a significant increase (p less than 0.05) by 21% from 1.62 +/- 0.76 to 1.96 +/- 0.91 mmol/l could be stated. The further increase after 4 hours by 10% was not significant. A standardized fat tolerance test concerning the triglycerides is apparently better suited for the estimation of the atherogenic risk than the determination of the fasting value alone.-By an additional determination of LPL and insulin as key enzyme and hormone, respectively, probably better statements could be made, which under equal conditions explain the interindividual differences of adipose persons in weight gain and weight reduction.

Adult↗
PubMedDate not supplied

[Subfractions of high density lipoproteins in relation to age].

In dependence on age women show both elevated levels of serum triglycerides and changes of lipid composition of HDL. A decrease of HDL- and HDL2-cholesterol levels and an increase of HDL- and HDL2-triglyceride concentrations are seen in the group of older persons. The concentration of HDL3-phospholipids decreases in dependence on aging. The content of triglycerides and the relation triglyceride/cholesterol of the subfraction HDL2, but not of HDL3, show positive correlations with the level of serum triglycerides. These changes are related to an age-dependent decrease of post-heparin lipolytic activity and a remodulation of HDL in dependence on the relation of the concentration of triglyceride rich lipoproteins and HDL.

Adolescent↗
PubMedDate not supplied

Lipoprotein levels of rural and urban persons of Ethiopia in dependence on age.

The levels of serum total cholesterol, LDL- and HDL-cholesterol, triglycerides and apolipoprotein B were determined in urban and rural persons of Ethiopia in dependency on age. Regarding total and LDL cholesterol a comparable age-dependency as in the population of other countries is observed. On the other hand higher values of these parameters were found in the serum of urban persons in comparison with rural subjects which may be a reflection of the different life style.

Adult↗
PubMedDate not supplied

[Lipogenesis, aging and hormonal regulation].

Thyroid hormones stimulate hepatic synthesis of fatty acids as well as activities of lipogenic enzymes. According to the present study, there also partially exists an age dependency. In livers of 3- and 18-month-old rats of the Wistar strain both the velocity of fatty acid synthesis and the activities of lipogenic enzymes were measured in dependence on thyroid function. An impaired stimulation of malic enzyme activity under hyperthyreosis conditions was found in the older animals. The velocity of fatty acid synthesis was diminished in the group of 18-month-old rats, but there was no age dependence with respect of the effect of a variation in thyroid status. In the adipose tissue of the older animals, the activities of lipogenic enzymes were lowered. In this tissue no effects of thyreohormones in either young or old rats were observed.

ATP Citrate (pro-S)-Lyase↗
PubMedDate not supplied

[Lipogenesis, aging and hormonal regulation].

Thyroid hormones stimulate hepatic synthesis of fatty acids, as well as the activities of lipogenic enzymes. According to the present study, an age-dependence factor is also partially present. In livers of 3- and 18-month-old rats of the Wistar strain, both the velocity of fatty acid synthesis and the activities of lipogenic enzymes were measured in dependence on thyroid function. An impaired stimulation of malic enzyme activity under the conditions of hyperthyreosis was found in the older animals. The rate of fatty acid synthesis was diminished in the group of 18-month-old rats, but there was no age-dependence in respect of the effect of a variation in thyroid status. In adipose tissue of older animals, the activities of lipogenic enzymes were lowered. In this tissue no effects of thyroid hormones in both young and old rats were observed.

ATP Citrate (pro-S)-Lyase↗
PubMedDate not supplied

[Effect of thyroid hormones on lipogenic liver enzymes in relation to age].

The influence of the thyrohormone status and of a nutrition rich in cholesterol on the hepatic enzymes glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, malate enzyme, and citrate cleavage enzyme was examined in female Wistar rats aged 3 and 18 months. Contrary to the findings in young animals, hyperthyreosis does not cause any significant increase in the activities of the malate enzyme and of the citrate cleavage enzyme. A nutrition rich in cholesterol induces a decrease of the activity of the malate enzyme in 3-month old rats; not, however, in the old rats.

ATP Citrate (pro-S)-Lyase↗
PubMedDate not supplied

[Biologic aging. 24. Circadian rhythm of lipid metabolism parameters in relation to age].

The age dependence of hepatic fatty acid synthesis and of the activities of lipogenic enzymes of the liver and of adipose tissue of Wistar-rats was investigated over the 24 hours period. The data were analyzed according to the so-called "cosinor procedure" for detecting circadian rhythms and for objectively describing their parameters. In the age groups 3 and 18 months hepatic fatty acid synthesis and the lipogenic liver enzymes glucose-6-phosphate dehydrogenase, 6-phospho-gluconate dehydrogenase and malic enzyme show circadian rhythms with maximum values in the early dark period. In adipose tissue of old rats the enzyme activities are lowered and no significant circadian rhythms for glucose-6-phosphate dehydrogenase and malic enzyme are detectable.

Adipose Tissue↗
PubMedDate not supplied

[The effect of D-penicillamine on experimental allergic arthritis in rabbits].

The effect of D-penicillamine on experimental allergic arthritis in rabbits (16 with arthritis and 15 controls) was investigated. After 40 days of treatment with D-penicillamine (intravenous) the arthritis had receded to a large extent. At the same time a maturation inhibition of the hematopoietic marrow had occurred in all the treated arthritic and control animals. The results suggest that D-penicillamine affects fast proliferating cells, to which the precursors of immunologically active cells in the synovial membrane also belong.

Animals↗
PubMedDate not supplied

[Age-related changes in lipid metabolism parameters: screening studies on a population basis].

Measurement of concentrations of total cholesterol, high density lipoprotein (HDL)-cholesterol and Lp(a) was carried out within a screening project on population basis including 3014 men and 5529 women of the town Leipzig. The age of the participants varied from 18 to 99 years. The aim of this population-based strategy was to identify individuals with elevated risk with regard to atherosclerotic diseases. There is an age dependence with a maximum of the ratio total cholesterol/HDL cholesterol in the age group 61-70 years. Between the ages 50 and 70 years, mean total cholesterol levels in women exceed those of men. Postmenopausal women show higher Lp(a) concentrations than premenopausal women. The observed age dependence of lipid profile may be the result of both intrinsic as well as of environmental factors which are characteristic for industrialized societies.

Adolescent↗