Search PubMed⌕ Search

Biomedical subjects

V Powell

Publications and source records attributed to V Powell.

18 recordsLinked to original sources
PubMed2006

Using NVDRS data for suicide prevention: promising practices in seven states.

OBJECTIVES: This article describes how seven states participating in a new public health surveillance system for violent death in the US, the National Violent Death Reporting System (NVDRS), have used data to support local suicide prevention activities. SETTING: The NVDRS is unique in that it augments death certificate data with event and circumstance information from death investigation reports filed by coroners, medical examiners, and law enforcement. These data illuminate why the victim ended his or her life, fatal injury patterns, and toxicological findings at death. RESULTS: Current suicide prevention efforts using these data fall into three categories: describing the problem of suicide and identifying opportunities for intervention; collaborating on statewide suicide prevention plans; and forming new partnerships for targeted prevention initiatives. Taken together, these three areas show early promise for state suicide prevention efforts. CONCLUSIONS: In each of the states, NVDRS data analyses are being shared with injury prevention colleagues, suicide prevention planning groups and policymakers, and adapted to respond to unique state and local suicide problems. A powerful surveillance tool, the NVDRS is bringing new clarity and direction to these state-based efforts. The NVDRS can serve as a model for other countries looking to establish timely suicide surveillance systems and data driven prevention strategies.

Adult↗
PubMed2006

From surveillance to action: early gains from the National Violent Death Reporting System.

OBJECTIVES: Drawing from the experiences of individual state programs that currently participate in the National Violent Death Reporting System (NVDRS), this article reviews some of the practical benefits that may accrue from the introduction of violent death surveillance systems. DESIGN: As a state-based surveillance system that uses multiple data sources and relies upon multiple stakeholders, the NVDRS program has fostered an array of initiatives within and among individual state programs. State-based initiatives highlighted in this article were selected on the basis of a purposive sampling strategy intended to illustrate key aspects of program development. SETTING: The NVDRS state programs are in Alaska, California, Colorado, Georgia, Kentucky, Maryland, Massachusetts, New Jersey, New Mexico, North Carolina, Oklahoma, Oregon, Rhode Island, South Carolina, Utah, Virginia, and Wisconsin. RESULTS: The NVDRS has helped to build alliances and collaborative efforts between key stakeholders, facilitated the recognition of violent death as a public health problem through outreach and media attention, acted as a catalyst for new projects, enhanced surveillance of special populations and utility for evaluation, and identified key circumstances that will target interventions in state prevention planning. CONCLUSIONS: The NVDRS has implemented data collection efforts and is beginning to produce and analyze findings. In the process of implementing the data collection system and publicizing findings, state NVDRS programs are realizing other gains that strengthen their surveillance efforts. The use of data for prevention purposes will be the ultimate indicator of program success.

Centers for Disease Control and Prevention, U.S.↗
PubMed2001

A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.

Genetic variations in the CC chemokine receptor (CCR5) leading to reduced or absent expression are associated with resistance to human immunodeficiency virus infection and delayed onset of acquired immunodeficiency syndrome. Similarly, lack of the red-cell chemokine receptor Duffy confers protection against malarial infection by Plasmodium vivax. Investigators have previously described a missense mutation (R89C) in the first intracellular loop of Duffy that results in reduced protein expression. The present study shows that the lower Duffy expression is due to loss of the positive charge at this position, resulting in protein instability. Moreover, R60S, a mutation in the first intracellular loop of CCR5 noted in a recent cohort study, likewise results in reduced surface expression and function of CCR5. The presence of a homologous, naturally occurring mutation that may be protective against disease thus defines a novel mechanism accounting for the decreased expression of these receptors in some individuals. (Blood. 2001;97:3651-3654)

Antigens, Protozoan↗
PubMed2001

Localization of Knops system antigens in the long homologous repeats of complement receptor 1.

BACKGROUND: The Sl(a) (Knops system) located on complement receptor 1 (CR1) has been associated with malarial rosetting, a process associated with severe malarial infections. Moreover, the long homologous repeats (LHRs) B and C of CR1 were implicated in rosette formation. As a step toward mapping the location of Knops system antigens, truncated CR1 proteins have been expressed and their ability to inhibit antibodies to the high-incidence Knops system antigens was assessed. STUDY DESIGN AND METHODS: Individual LHRs (A, B, C, and D) of CR1 of the common CR1*1 (F) allotype were expressed as secreted forms in 293T cells. Their abilities to specifically neutralize Knops system antibodies were tested by both hemagglutination and flow cytometry. RESULTS: Three examples of anti-Kn(a) (n = 6) were almost completely inhibited by LHR-C and three by LHR-D. Two examples of anti-McC(a) (n = 2) and seven examples of anti-Sl(a) (n = 8) were inhibited by LHR-D. Both examples of anti-Yk(a) (n = 2) were partially inhibited by LHR-D. CONCLUSION: The high-incidence Knops system antigens reside within LHR-D and to a lesser extent within LHR-C. Because of the role of Sl(a) antigen in malaria rosetting, these results indicate that LHR-D may represent an additional malaria interaction region in CR1.

Antibodies, Monoclonal↗
PubMed2001

Mid-thoracic tenderness: a comparison of pressure pain threshold between spinal regions, in asymptomatic subjects.

Palpation for tenderness forms an important part of the manual therapy assessment for musculoskeletal dysfunction. In conjunction with other testing procedures it assists in establishing the clinical diagnosis. Tenderness in the thoracic spine has been reported in the literature as a clinical feature in musculoskeletal conditions where pain and dysfunction are located primarily in the upper quadrant. This study aimed to establish whether pressure pain thresholds (PPTs) of the mid-thoracic region of asymptomatic subjects were naturally lower than those of the cervical and lumbar areas. A within-subject study design was used to examine PPT at four spinal levels C6, T4, T6, and L4 in 50 asymptomatic volunteers. Results showed significant (P<0.001) regional differences. PPT values increased in a caudal direction. The cervical region had the lowest PPT scores, that is was the most tender. Values increased in the thoracic region and were highest in the lumbar region. This study contributes to the normative data on spinal PPT values and demonstrates that mid-thoracic tenderness relative to the cervical spine is not a normal finding in asymptomatic subjects.

Adult↗
PubMed2000

The use of cluster sampling to determine aid needs in Grozny, Chechnya in 1995.

War broke out in Chechnya in November 1994 following a three-year economic blockade. It caused widespread destruction in the capital Grozny. In April 1995 Medical Relief International--or Merlin, a British medical non-governmental organisation (NGO)--began a programme to provide medical supplies, support health centres, control communicable disease and promote preventive health-care in Grozny. In July 1995 the agency undertook a city-wide needs assessment using a modification of the cluster sampling technique developed by the Expanded Programme on Immunisation. This showed that most people had enough drinking-water, food and fuel but that provision of medical care was inadequate. The survey allowed Merlin to redirect resources earmarked for a clean water programme towards health education and improving primary health-care services. It also showed that rapid assessment by a statistically satisfactory method is both possible and useful in such a situation.

Cluster Analysis↗
PubMed2000

Identification of adult populations at high risk for dental caries using a computerized database and patient records: a pilot project.

OBJECTIVES: The purpose of this study is to test the usefulness of dental insurance claims history, supplemented with radiographic caries diagnoses, as a means of identifying caries-active and caries-inactive working adults, as determined by bacterial levels. Computerized identification of at-risk groups may facilitate subject selection for clinical trials designed to test caries-preventive strategies. METHODS: Two groups of subjects were initially selected from an insurance database based upon their dental service utilization during a one-year period: a "low restorative" group of individuals defined as persons who had received no restorative treatment, and a "high restorative" group comprised of individuals who had received at least three multisurfaced restorations. A chart review confirmed a diagnosis of caries in the high restorative group and an absence of caries in the low restorative group. Subjects were then approached for saliva collection. The low and high restorative groups were compared for salivary mutans streptococci and lactobacilli levels, stimulated flow rate, and buffer capacity (n = 48). RESULTS: The high and low restorative groups differed in mutans streptococci levels, but not on other measures. CONCLUSIONS: A group of subjects who had recently received multisurfaced restorations that were placed for reasons of caries had significantly higher levels of mutans streptococci and potential for continued caries activity when compared to a group of subjects who had received no restorations and were caries free.

Adult↗
PubMed1998

The recognition of vowels produced by men, women, boys, and girls by cochlear implant patients using a six-channel CIS processor.

Five patients who used a six-channel, continuous interleaved sampling (CIS) cochlear implant were presented vowels, in two experiments, from a large sample of men, women, boys, and girls for identification. At issue in the first experiment was whether vowels from one speaker group, i.e., men, were more identifiable than vowels from other speaker groups. At issue in the second experiment was the role of the fifth and sixth channels in the identification of vowels from the different speaker groups. It was found in experiment 1 that (i) the vowels produced by men were easier to identify than vowels produced by any of the other speaker groups, (ii) vowels from women and boys were more difficult to identify than vowels from men but less difficult than vowels from girls, and (iii) vowels from girls were more difficult to identify than vowels from all other groups. In experiment 2 removal of channels 5 and 6 from the processor impaired the identification of vowels produced by women, boys and girls but did not impair the identification of vowels produced by men. The results of experiment 1 demonstrate that scores on tests of vowels produced by men overestimate the ability of patients to recognize vowels in the broader context of multi-talker communication. The results of experiment 2 demonstrate that channels 5 and 6 become more important for vowel recognition as the second formants of the speakers increase in frequency.

Adult↗
PubMed1990

Rotation flap.

Explore the source record for details and available documents.

Basal Cell Carcinoma↗
PubMed1987

Clinical performance of interns after being on call.

We assessed the effect of in-hospital call on clinical performance and emotional state in seven medical interns. Clinical performance was evaluated through the use of actors who were trained to pose as patients seeking consultation because of specific medical complaints. The physician-patient interaction was scored according to predetermined criteria. There was no significant difference in interns' performance whether or not the preceding 24 hours had been spent on call. On a standardized questionnaire, interns reported significantly more fatigue and depression after call. We conclude that the major discernible effect of call is a deterioration of interns' feelings of well-being.

Clinical Competence↗
PubMed1977

Primary fibrosarcoma of the diaphragm.

Primary tumours of the diaphragm are rare. Benign neoplasms occur more frequently than malignant ones. Among the latter, fibrosarcoma is the most common. A case of primary fibrosarcoma of the diaphragm is presented with long survival and recurrence 10 years after first surgical removal. At re-operation, a huge tumour was excised arising from a small part of the diaphragm. The histology of the recurrence was the same as the original tumour. The patient remained free of signs and symptoms nine months after the second operation.

Diaphragm↗