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Biomedical subjects

V Petkova

Publications and source records attributed to V Petkova.

29 records · Page 2Linked to original sources
PubMed1991

[The clinical picture and diagnosis of manganese-induced parkinsonism].

As a result of 5-year-long electromyographic observation of 144 persons engaged in ferroalloy production, the parkinsonism syndrome was diagnosed in 4 persons. The disease development was slow, gradual, with the muscular tension growth against the asthenovegetative symptoms. This particularity did not correspond to the traditional view of the three-stage development of chronic manganese intoxication prior to the acute phase of manganese parkinsonism. The contributors hold that the stretch reflex proved to be the most early-stage oriented, prognostically and diagnostically reliable among the other electromyographic techniques.

Adult↗
PubMed1987

[Bromsulphalein clearance in persons in occupational contact with pesticides].

In 46 persons (sprayers, disinfectors, technicians of the agricultural aviation) the bromsulphalein clearance is traced, during the active work season with pesticides, after the method of Caroly, Nys and Alliot. It is established, that the mean value of bromsulphalein clearance (8.91%) is lower than that of the referent group healthy persons (14.5%). In 14 (31.34%) of the examined the values of the clearance are under 10%. The changes of the last do not correlate closely to other indices of the liver function. As an explanation of the results the authors presuppose general pathogenetic relations between the metabolism of pesticides and of bromsulphalein in the liver cell, with inclusion of glutathione-S-transferase systems. The study allows to give a practical conclusion for the meaning of the bromsulphalein clearance and assessment of the pesticides effect in persons who are in professional contact with them.

Adult↗
PubMed1980

[Enzymatic changes in chronic pesticide exposure].

Activity of some enzymes (GOT, GPT, OCT, AP, GGTP, HE) was studied in a group of 74 workers, exposed to professional chronic combined pesticide effects. Enzyme changes were followed up depending on exposure. There was a statistically significant increase in GOT, GPT and OCT activities and decrease in HE. Paralleling this, an insignificant depression of AP and GGTP in comparison with the control group was observed. The relationship between these enzyme changes and liver function are discussed. Implication of toxic factor in the development of these changes is suggested.

Adult↗
PubMedDate not supplied

Low dose treatment with methotrexate-adverse drug reactions survey.

Antineoplastic drugs caused various and frequent adverse drug reactions (ADR) in connection with their pharmacodynamics. Methotrexate (MTX) ADRs are preferably gastrointestinal disorders and hepatotoxicity (hepatic enzyme abnormalities). The aim of this study was to detect and analyse ADR induced by low-dose MTX treatment in rheumatology. We observed 94 patients, 63 with rheumatoid arthritis and 31 with psoriatic arthritis. All patients were co-medicated with nonsteroidal anti-inflammatory drugs (NSAID) as Diclofenacum, Indomethacinum, Piroxicamum and 51% with glycocorticosteroides. During the follow-up study we collected 18 case-reports with ADR for 17% of the patients. From the patients with registered ADR, 11 was treated with standard dose of 7.5 mg MTX for a week and 7 patients received from 10 to 15 mg for a week. The distribution of the cases according patients' gender was 9 females and 7 males. Prevail individuals in age groups' 41-50 and over 61 years. The most frequent adverse drug reactions were leucopenia, trombocytopenia, skin reactions and gastrointestinal disorders as vomiting, melaena, epigastrial pain, etc. The primary risk connected with long therapy of low doses MTX is hepatotoxicity that diagnose and treatment are painful and expensive. As a result of the appearance of ADR in 5 patients the therapy with MTX was not changed, in two cases MTX is stopped timely or the dosage is changed and in the rest 11 patients MTX was excluded from the therapeutic scheme.

Adult↗
PubMedDate not supplied

An attempt for complex assessment of the elderly patients' compliance.

Compliance is taking the correct amount of the correct medicine at the correct time. Today, the problem of prescription medicine noncompliance is gaining considerably more attention within the pharmacy community as a part of the pharmaceutical care and by the other health professionals. Sometimes, compliance is defined "objectively" by how much medication a patient takes, such as taking a certain percentage of prescribed medication or taking a certain number of pills over a specific time period. Undoubtedly the care for the elderly patients and especially for the elderly patients that are bedridden can be an especially difficult challenge. The extent of non-compliance among them is estimated to be about 40% to 50%. The aim of this research is to assess the level of compliance and the factors, that influence this process among a group of elderly patients. We applied a complex methodology in order to avoid the mistakes that are connected with the use of a single method separately.

Aged↗
PubMedDate not supplied

Psychotropic drugs in Bulgaria-frequency and risk of adverse drug reactions.

The aim of the study is to determine the frequency and risk of appearance of adverse drug reactions/ADRs/during the treatment with psychotropic drugs. The first part of the study is an analysis of the use of the psychotropic drugs for one-year period of time in our country, performed by DDD methodology. An attempt is made to equalize the Bulgarian list of the psychotropic drugs with the ATC classification and to estimate the DDD/1000/day. The data for Bulgaria is compared with that of the other countries. The collected data for the psychotropic drug use is divided into 2 groups: Psycholeptics and Psychoanaleptics. It is made an attempt to explain the main differences between them. The number of the standard therapeutic courses/NT/is used for assessment of the frequency and risk of ADRs. The results from the study show that the determined frequency of appearance of ADR for the different drugs is within "rare" and "very rare' for 100,000 inhabitants, according to the WHO terminology. Only for the drug Tardyl (EGIS Pharmaceuticals, Hungary) with INN Aminobarbitalum + Glutethimidum + Promethazini hydrochloridum the frequency is above 1%. That fact makes us to recommend a limitation of the prescription and usage of this drug to the Bulgarian Ministry of Health and to the National Drug Agency.

Bulgaria↗
PubMedDate not supplied

Pharmaco-economical analysis of the treatment with antibiotics in a surgery department.

The fulfillment of a pharmaco-economical analysis of the treatment with antibiotics is an important task in the conditions of a transition period, that is currently in Bulgaria. The great problem with the insufficient financial sources prevents the supply with drugs, medical supply and technology. This analysis is a kind of an auxiliary source in the process of managing in the sphere of the health policy and in particular--in the sphere of the pharmacy.

Adult↗
PubMedDate not supplied

Asthma, drug medication and noncompliance.

UNLABELLED: According to the new concepts, asthma is a chronic disease of the upper respiratory tracts, caused by different cells, including the mastocits and eozinofils. The patients that are suffering from episodic, frequent, or chronic asthma are participating very energetic in the treatment--they have to know and control the symptoms of their disease and also to possess technical skills to perform the treatment. METHODOLOGY: Between March 1 and July 31, 1999, 30 patients [19 women and 11 men, mean age 35 years (range 2.50 to 65)], followed at the Clinic for Allergic Diseases of the University hospital "Aleksandrovska", Medical University of Sofia, Bulgaria, were interviewed blindly in order to assess their compliance with pharmacologic therapy. All patients were suffering from different types of asthma. RESULTS: The level of compliance among the studied group of patients is 86%. In comparison with the literary data where the level of non-compliance is 20% the obtained level is lower--14%. The reasons for non-compliance according to the patients are: the appearance of ADRs, the high prize of the drugs, the hard application of the drug form.

Adolescent↗
PubMedDate not supplied

[Evaluation of initial results of treatment of lead poisoning with EDTA].

The results of EDTA therapy were studied in 37 workers of a battery factory consisting of males with varying degrees of occupational lead poisoning (low exposure: 10 subjects, blood lead levels (PbB) lower than 400 micrograms/l with slight alterations in heme biosynthesis; beyond limit of effect: 5 subjects, PbB > 400 micrograms/l; slight intoxication: 19 subjects, with marked alterations in heme synthesis and preclinical signs of intoxication; average degree of intoxication: 3 subjects with clinical signs of intoxication. Clinical symptoms and the following parameters were investigated: blood lead (PbB), delta-aminolevulinic acid dehydratase in erythrocytes (ALA-D), zinc protoporphyrin (PP) in erythrocytes and delta-aminolevulinic acid (ALA) in 24-hour urine before and after EDTA chelating therapy. Simultaneous measurement of ALA-D and PP showed high diagnostic sensitivity in detecting lead poisoning in occupationally exposed subjects. In view of the high interindividual variability of the results, these indices did not, however, permit a useful differentiation to be made of the different degrees of intoxication at individual level, even though a good correlation was observed between PbB and porphyrin metabolism indices. From the alterations observed in ALA-D and PP values it was not possible to establish an association between degree of alteration and types of clinical symptoms in the different intoxication studies. At the end of EDTA treatment, a clinical improvement was observed in all cases studied but only in 5 cases was a reduction in PbB observed, to levels below 1.20 mol/l, which is accepted as a permissible limit for the general population; in 17 cases PbB remained at levels above the critical value for occupational lead poisoning (400 micrograms/l), although there was a decrease after treatment. The improvement observed in the indices of porphyrin metabolism at the end of treatment was only slight: significant variations were measured only for PbB. After treatment no association was observed between ALA-D and PP variations in erythrocytes and improvement in clinical symptoms; measurement of these indices therefore seems to be of little use in assessing the efficacy of the treatment. In spite of its limited diagnostic sensitivity during intoxication, measurement of ALA in urine could be useful to assess the efficacy of chelating therapy in subjects in whom the values are initially altered.

Adult↗